Methylprednisolone acetate
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Methylprednisolone acetate
structure -
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CAS No:
53-36-1
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Formula:
C24H32O6
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Chemical Name:
Methylprednisolone acetate
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Synonyms:
Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-11,17-dihydroxy-6-methyl-,(6α,11β)-;Pregna-1,4-diene-3,20-dione,11β,17,21-trihydroxy-6α-methyl-,21-acetate;(6α,11β)-21-(Acetyloxy)-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione;Depo-Medrol;Medrol acetate;6α-Methylprednisolone acetate;Urbason Crystal Suspension;MPA;Methylprednisolone acetate;U 8210;Methylprednisolone 21-acetate;6α-Methylprednisolone 21-acetate;21-Acetoxy-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione;Depo-methylprednisolone;6-Methylprednisolone acetate;Depo-Medrate;Depo-Medrone;DepMedalone 40;Vetacortyl;DepMedalone 80;Mepred;NSC 48985;11β,17α,21-Trihydroxy-6α-methylpregna-1,4-diene-3,20-dione 21-acetate
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Categories:
Active Pharmaceutical Ingredients > Hormones and the Endocrine System
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CAS No:
Description
Off-White Solid
Methylprednisolone acetate is an acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid. It has a role as an anti-inflammatory drug. It is a 20-oxo steroid, a 17alpha-hydroxy steroid, an 11beta-hydroxy steroid, a glucocorticoid, an acetate ester, a steroid ester, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It derives from a 6alpha-methylprednisolone.|Methylprednisolone Acetate is the acetate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and antiinflammatory effects. Methylprednisolone acetate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.|Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.
Methylprednisolone acetate Basic Attributes
416.51
416.51
200-171-3
43502P7F0P
48985
DTXSID7023302
C48003
32041200
Characteristics
100.90000
3.08
1.3±0.1 g/cm3
205-208 °C
582.5±50.0 °C at 760 mmHg
196.5±23.6 °C
1.580
Refrigerator
LD50 oral in rat: > 10gm/kg
D20 +101° (dioxane)
Safety Information
NONH for all modes of transport
3
63-62
36/37-24/25
Xn
P201-P308 + P313
H361
|Danger|H360 (40.26%): May damage fertility or the unborn child [Danger Reproductive toxicity]|P201, P202, P260, P281, P308+P313, P314, P405, and P501|Aggregated GHS information provided by 77 companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Drug Information
Substances that reduce or suppress INFLAMMATION. (See all compounds classified as Anti-Inflammatory Agents.)
Acetyl Methylprednisolone
Methylprednisolone acetate Use and Manufacturing
6α-Methyl Prednisolone 21-Acetate is used as a glucocorticoid.
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
Computed Properties
Molecular Weight:416.5
XLogP3:2.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:416.21988874
Monoisotopic Mass:416.21988874
Topological Polar Surface Area:101
Heavy Atom Count:30
Complexity:858
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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