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Methanide

Methanide structure

CAS No:
53-46-3
Formula:
C21H26NO3.Br
Chemical Name:
Methanide
Synonyms:
Ethanaminium,N,N-diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]-,bromide (1:1);Ammonium,diethyl(2-hydroxyethyl)methyl-,bromide,xanthene-9-carboxylate;Diethyl(2-hydroxyethyl)methylammonium bromide,xanthene-9-carboxylate;Ethanaminium,N,N-diethyl-N-methyl-2-[(9H-xanthen-9-ylcarbonyl)oxy]-,bromide;MTB 51;SC 2910;Asabaine;Avagal;Banthine;Banthine bromide;β-Diethylaminoethyl xanthene-9-carboxylate methobromide;Doladene;Gastron;Gastrosedan;Metantyl;Metaxan;Methanide;Methantheline bromide;Methanthine bromide;Vagamin;Xanteline;Methanthelinium bromide;Banthin;Vagantin;Ulcudexter;Methelina;Frenogastrico;Mantheline;Resobantin;Ulcine;Metanyl;Uldumont;Dixamone bromide
Categories:
Organic Chemistry > Amides

Description

Methantheline bromide is a member of xanthenes.|A quaternary ammonium compound that acts as an antimuscarinic agent. It has been used in the treatment of PEPTIC ULCER, in gastrointestinal disorders associated with smooth muscle spasm, and in the management of urinary incontinence, and may also be used for the treatment of HYPERHIDROSIS.

Methanide Basic Attributes

Molecular Weight：

420.34000

Exact Mass：

419.11000

EC Number：

200-176-0

UNII：

090519SAPF

NSC Number：

32145

DSSTox ID：

DTXSID7023277

HScode：

2932999099

Characteristics

PSA：

35.53000

XLogP3：

0.95780

Density：

1.3380 (rough estimate)

Melting Point：

174.5 °C

Toxicity：

LD50 i.p. in mice: 76 mg/kg (Hambourger)

Safety Information

Transport codes：

NONH for all modes of transport

Precautionary statement(s)：

P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P301+P312, P304+P312, P304+P340, P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH：

Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. (See all compounds classified as Muscarinic Antagonists.)

MeSH Entry Terms：

Banthine

Methanide Use and Manufacturing

Uses

METHANTHELINE BROMIDE is a strong muscarinic receptor blocking drug used in the treatment of overactive bladder syndrome, hypersalivation and hyperhidrosis.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:420.3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:419.10961
Monoisotopic Mass:419.10961
Topological Polar Surface Area:35.5
Heavy Atom Count:26
Complexity:426
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes