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5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole

5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole structure

CAS No:
53-85-0
Formula:
C12H12Cl2N2O4
Chemical Name:
5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole
Synonyms:
1H-Benzimidazole,5,6-dichloro-1-β-D-ribofuranosyl-;Benzimidazole,5,6-dichloro-1-β-D-ribofuranosyl-;Benzimidazole,5,6-dichloro-1-D-ribofuranosyl-;5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole;5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole;1-β-D-Ribofuranosyl-5,6-dichlorobenzimidazole;DRB;NSC 401575;5,6-Dichlorobenzimidazole 1-β-D-ribofuranoside;5,6-Dichlororibofuranosylbenzimidazole;NQZ-002;909276-76-2;1821045-35-5
Categories:
Biochemical Engineering > Saccharides

Description

White Solid

An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.

5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole Basic Attributes

Molecular Weight：

319.14

Exact Mass：

319.14

UNII：

8153319T3Q

HScode：

29349990

Characteristics

PSA：

87.7

XLogP3：

2.05

Appearance：

White to off-white crystalline solid.

Density：

1.8±0.1 g/cm3

Melting Point：

215-216 °C

Boiling Point：

606.2±65.0 °C at 760 mmHg

Flash Point：

320.4±34.3 °C

Refractive Index：

1.750

Water Solubility：

soluble in DMSO to 75mM. soluble in dimethyl sulfoxide, hot ethanol, dimethyl formamide, (1:2) dimethyl formamide:Phosphate buffer saline, water, methanol and pyridine. Slightly soluble in aqueous buffers.

Storage Conditions：

−20°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

24/25

RTECS Number：

DD7310000

Drug Information

MeSH：

Compounds that inhibit cell production of DNA or RNA. (See all compounds classified as Nucleic Acid Synthesis Inhibitors.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

5,6 Dichloro 1 beta D ribofuranosyl 1 H benzimidazol

5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole Use and Manufacturing

An inhibitor of RNA synthesis (causes premature termination of transcription)

Computed Properties

Molecular Weight:319.14
XLogP3:1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:318.0174123
Monoisotopic Mass:318.0174123
Topological Polar Surface Area:87.7
Heavy Atom Count:20
Complexity:364
Defined Atom Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of 5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Learn More Other Chemicals

5,6-Dichloro-1-(β-D-ribofuranosyl)benzimidazole

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