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Ellipticine

Ellipticine structure

CAS No:
519-23-3
Formula:
C17H14N2
Chemical Name:
Ellipticine
Synonyms:
6H-Pyrido[4,3-b]carbazole,5,11-dimethyl-;Ellipticine;5,11-Dimethyl-6H-pyrido[4,3-b]carbazole;NSC 71795;CP 5
Categories:
Natural Products > Alkaloids

Description

Ellipticine hydrochloride is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

Ellipticine is a organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11. It has a role as an antineoplastic agent and a plant metabolite. It is an organic heterotetracyclic compound, an organonitrogen heterocyclic compound, a polycyclic heteroarene and an indole alkaloid.

Ellipticine Basic Attributes

Molecular Weight：

246.31

Exact Mass：

246.31

EC Number：

208-264-0

UNII：

117VLW7484

NSC Number：

71795

DSSTox ID：

DTXSID30199855

HScode：

2933990090

Characteristics

PSA：

28.7

XLogP3：

4.80

Density：

1.3±0.1 g/cm3

Melting Point：

313 °C

Boiling Point：

495.4±40.0 °C at 760 mmHg

Flash Point：

227.1±18.6 °C

Refractive Index：

1.777

Water Solubility：

DMSO: soluble

Storage Conditions：

2-8°C

Toxicity：

LD50 in mice (mg/kg): 19.5-22.4 i.v.; 178-204 orally (Rakieten)

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 3462 6.1/PG 3

wgk germany：

hazard class code：

safety instructions：

RTECS Number：

UU8825000

Marks：

Precautionary statement(s)：

P264, P270, P301+P310, P321, P330, P405, P501

Hazard Statements：

H301

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Chemical agents that uncouple oxidation from phosphorylation in the metabolic cycle so that ATP synthesis does not occur. Included here are those IONOPHORES that disrupt electron transfer by short-circuiting the proton gradient across mitochondrial membranes. (See all compounds classified as Uncoupling Agents.)

MeSH Entry Terms：

5,11-dimethyl-6H-pyrido(4,3-b)carbazole

Computed Properties

Molecular Weight:246.31
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:246.115698455
Monoisotopic Mass:246.115698455
Topological Polar Surface Area:28.7
Heavy Atom Count:19
Complexity:342
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Ellipticine

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Computed Properties
Learn More Other Chemicals

Ellipticine

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