Iproniazid
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Iproniazid
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CAS No:
54-92-2
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Formula:
C9H13N3O
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Chemical Name:
Iproniazid
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Synonyms:
4-Pyridinecarboxylic acid,2-(1-methylethyl)hydrazide;Isonicotinic acid,2-isopropylhydrazide;IPN;Iprazid;Iproniazid;Marsilid;Iprazide;Iproniazide;Isonicotinic acid N′-isopropyl hydrazide;N′-Isopropylisonicotinoylhydrazide;Euphozid;Marsalid;1-Isonicotinoyl-2-isopropylhydrazine
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CAS No:
Description
Iproniazid is a carbohydrazide and a member of pyridines.|Withdrawn from the Canadian market in July 1964 due to interactions with food products containing tyrosine.|An irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity.
Iproniazid Basic Attributes
179.223
179.22
200-218-8
D892HFI3XA
DTXSID5023168
N - Nervous system
2933399090
Safety Information
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Drug Information
For the treatment of depression (originally intended to treat tuberculosis).
Iproniazid is a monoamine oxidase inhibitor (MAOI) that was developed as the first anti-depressant.
Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)
Iprazid
Iproniazid Use and Manufacturing
Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.
Pharmaceuticals
Computed Properties
Molecular Weight:179.22
XLogP3:0.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:179.105862047
Monoisotopic Mass:179.105862047
Topological Polar Surface Area:54
Heavy Atom Count:13
Complexity:164
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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