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(±)-Methyldopa

(±)-Methyldopa structure

CAS No:
55-40-3
Formula:
C10H13NO4
Chemical Name:
(±)-Methyldopa
Synonyms:
Tyrosine,3-hydroxy-α-methyl-;Alanine,3-(3,4-dihydroxyphenyl)-2-methyl-;3-Hydroxy-α-methyltyrosine;(±)-Methyldopa;Racemic α-methyldopa;DL-α-Methyl DOPA;(±)-α-Methyldopa;DL-Methyldopa;Metholes;Mulfasin;DL-2-Methyl-3-(3,4-dihydroxyphenyl)alanine;DL-α-Methyl-3-(3,4-dihydroxyphenyl)alanine;2-(3,4-Dihydroxybenzyl)-2-aminopropanoic acid;3-Hydroxy-α-methyl-DL-tyrosine;2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;2-Azaniumyl-3-(3,4-dihydroxyphenyl)-2-methylpropanoate;555-29-3
Categories:
Organic Chemistry > Amides

Description

Grey Solid

3-Hydroxy-alpha-methyl-DL-tyrosine is a monocarboxylic acid and a member of benzenes.|An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

(±)-Methyldopa Basic Attributes

Molecular Weight：

211.214

Exact Mass：

211.21

EC Number：

209-088-7

NSC Number：

169916

ATC Code：

C - Cardiovascular system

HScode：

2922509090

Characteristics

PSA：

103.78000

XLogP3：

0.13

Density：

1.4±0.1 g/cm3

Melting Point：

299-300.5 °C (decomp)

Boiling Point：

441.6±45.0 °C at 760 mmHg

Flash Point：

220.9±28.7 °C

Refractive Index：

1.635

Water Solubility：

Soluble in isopropanol, ethanol, and water.

Storage Conditions：

Methyldopa oral suspension should be stored in tight, light-resistant containers at a temperature less than 26 deg C and protected from freezing. Methyldopa tablets should be stored in well-closed containers at a temperature less than 40 deg C, preferably at 15-30 deg C.

Safety Information

wgk germany：

hazard class code：

safety instructions：

S26-S37/39

Marks：

Stability/Shelf Life：

Methyldopa is decomposed by oxidizing agents.

Precautionary statement(s)：

P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (19.15%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|Aggregated GHS information provided by 47 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS. (See all compounds classified as Adrenergic alpha-2 Receptor Agonists.)|Drugs that inhibit the actions of the sympathetic nervous system by any mechanism. The most common of these are the ADRENERGIC ANTAGONISTS and drugs that deplete norepinephrine or reduce the release of transmitters from adrenergic postganglionic terminals (see ADRENERGIC AGENTS). Drugs that act in the central nervous system to reduce sympathetic activity (e.g., centrally acting alpha-2 adrenergic agonists, see ADRENERGIC ALPHA-AGONISTS) are included here. (See all compounds classified as Sympatholytics.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)

MeSH Entry Terms：

Aldomet

(±)-Methyldopa Use and Manufacturing

Uses

Antihypertensive agent

Manufacturing Info：

L-Tyrosine, 3-hydroxy-.alpha.-methyl-: INACTIVE

Computed Properties

Molecular Weight:211.21
XLogP3:-1.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:211.08445790
Monoisotopic Mass:211.08445790
Topological Polar Surface Area:104
Heavy Atom Count:15
Complexity:246
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes