 Home > Encyclopedia > Methylaminoantipyrine

Methylaminoantipyrine

Methylaminoantipyrine structure

CAS No:
519-98-2
Formula:
C12H15N3O
Chemical Name:
Methylaminoantipyrine
Synonyms:
3H-Pyrazol-3-one,1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-;Antipyrine,4-(methylamino)-;1,2-Dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one;Noraminopyrine;4-Monomethylaminoantipyrine;4-(Methylamino)antipyrine;4-Monomethylaminophenazone;N-Methyl-4-aminoantipyrine;Monomethylaminoantipyrine;Noramidopyrine;N-Methylaminoantipyrine;Methylaminoantipyrine;4-Methylaminophenazone;N-Methylaminophenazone;Methylaminophenazone;N-Methyl-4-aminophenazone;1,5-Dimethyl-4-methylamino-2-phenyl-1,2-dihydro-pyrazol-3-one;1,5-Dimethyl-4-(methylamino)-2-phenyl-2,3-dihydro-1H-pyrazol-3-one;141504-64-5
Categories:
Specialty Chemicals

Description

4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic drug and can be used for pain and fever[1][2][3]. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak antiinflammatory properties[2].

4-(methylamino)antipyrine is a member of the class of pyrazoles that is antipyrine substituted at C-4 by a methylamino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-narcotic analgesic, an opioid analgesic, a non-steroidal anti-inflammatory drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, a peripheral nervous system drug, an antipyretic and a drug metabolite. It is a member of pyrazoles and a secondary amino compound. It derives from an antipyrine.

Methylaminoantipyrine Basic Attributes

Molecular Weight：

217.267

Exact Mass：

217.27

EC Number：

208-281-3

UNII：

NER31DE951

DSSTox ID：

DTXSID80199865

HScode：

2933199090

Characteristics

PSA：

35.6

XLogP3：

0.02

Density：

1.2±0.1 g/cm3

Melting Point：

63 °C

Boiling Point：

324.5±45.0 °C at 760 mmHg

Flash Point：

150.0±28.7 °C

Refractive Index：

1.619

Storage Conditions：

-20°C Freezer

Toxicity：

LD50 oral in mouse: 7gm/kg

Safety Information

Hazard category：

IRRITANT

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

methylaminoantipyrine

Methylaminoantipyrine Use and Manufacturing

Methods of Manufacturing

Formylation with aminoantipyrine with formic acid to produce 4-(formylamino)antipyrine, and then methylation with dimethyl sulfate under alkaline conditions to give 4-formylaminoaminoantipy Lin, hydrolyze the latter with sulfuric acid (remove the formyl group) and neutralize the product.

Uses

A metabolite of Dipyrone

Use Classification：

Pharmaceuticals

Computed Properties

Molecular Weight:217.27
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:217.121512110
Monoisotopic Mass:217.121512110
Topological Polar Surface Area:35.6
Heavy Atom Count:16
Complexity:318
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Methylaminoantipyrine

Kindchem Co., Ltd Contact Supplier

CN
4 YRS

Business licensed

Trader Supplier of API OLED Organic intermediate

1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one Kindchem

CAS No.: 519-98-2

Inquiry