Nepetin
-
Nepetin
structure -
-
CAS No:
520-11-6
-
Formula:
C16H12O7
-
Chemical Name:
Nepetin
-
Synonyms:
4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-;Flavone,3′,4′,5,7-tetrahydroxy-6-methoxy-;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;Eupafolin;Nepetin;6-Methoxyluteolin;3′,4′,5,7-Tetrahydroxy-6-methoxyflavone;NSC 122416;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
- Categories:
-
CAS No:
Description
Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2].
Drug Information
6-Methoxyluteolin has known human metabolites that include (2S,3S,4S,5R)-6-[2-(3,4-Dihydroxyphenyl)-5-hydroxy-6-methoxy-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid.
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
Nepetin Use and Manufacturing
Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]
Computed Properties
Molecular Weight:316.26
XLogP3:1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:316.05830272
Monoisotopic Mass:316.05830272
Topological Polar Surface Area:116
Heavy Atom Count:23
Complexity:491
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Learn More Other Chemicals
-
Schaftoside
51938-32-0
-
3-carboxy-2,3-dideoxy-1-hydroxypropan-1,2,3-tricarboxylic acid
320-77-4
-
Deoxyarbutin
53936-56-4
-
Punicalagin Formula
65995-63-3
-
Phloretin Formula
60-82-2
-
Salvianic acid A Formula
76822-21-4
-
Rhein Structure
478-43-3
-
Chrysophanol Structure
481-74-3
-
What is 1-Naphthalenesulfonic acid, 7-hydroxy-, potassium salt (1:1)
30252-40-5
-
What is Tribulosin
79974-46-2