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Nepetin

Nepetin structure

CAS No:
520-11-6
Formula:
C16H12O7
Chemical Name:
Nepetin
Synonyms:
4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-;Flavone,3′,4′,5,7-tetrahydroxy-6-methoxy-;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one;Eupafolin;Nepetin;6-Methoxyluteolin;3′,4′,5,7-Tetrahydroxy-6-methoxyflavone;NSC 122416;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one;2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one
Categories:
Biochemical Engineering > Plant Extracts

Description

Nepetin (6-Methoxyluteolin) is a natural flavonoid isolated from Eupatorium ballotaefolium HBK with potent anti-inflammatory activities. Nepetin inhibits IL-6, IL-8 and MCP-1 secretion with IC50 values of 4.43 μM, 3.42 μM and 4.17 μM, respectively in ARPE-19 cells[1][2].

Nepetin Basic Attributes

Molecular Weight：

316.26

Exact Mass：

316.26

UNII：

I3O7LF3GED

NSC Number：

122416

DSSTox ID：

DTXSID10199959

HScode：

2914509090

Characteristics

PSA：

116

XLogP3：

1.89

Density：

1.6±0.1 g/cm3

Melting Point：

262-264 °C

Boiling Point：

659.1±55.0 °C at 760 mmHg

Flash Point：

90℃

Refractive Index：

1.727

Drug Information

Metabolism/Metabolites：

6-Methoxyluteolin has known human metabolites that include (2S,3S,4S,5R)-6-[2-(3,4-Dihydroxyphenyl)-5-hydroxy-6-methoxy-4-oxochromen-7-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid.

MeSH Entry Terms：

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy-4H-chromen-4-one

Nepetin Use and Manufacturing

Use Classification：

Polyketides [PK] -> Flavonoids [PK12] -> Flavones and Flavonols [PK1211]

Computed Properties

Molecular Weight:316.26
XLogP3:1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:316.05830272
Monoisotopic Mass:316.05830272
Topological Polar Surface Area:116
Heavy Atom Count:23
Complexity:491
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Related Drugs

Shujin Huoxue Tablets
Ingredients	Safflower, Cibotium barometz, mistletoe, Zedoaria leaf, Millettia reticulata, Trachelospermum officinale, Lycopodiella ciliata, Cyperus rotundus, Cyperus rotundus bark, and natural copper.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet weighs 0.32g
Manufacturer	Ningbo Liwah Pharmaceutical Co., Ltd.

Shujin Huoxue Tablets
Ingredients	Safflower, Cibotium barometz, mistletoe, Zedoaria leaf, Millettia reticulata, Trachelospermum officinale, Lycopodiella ciliata, Cyperus rotundus, Cyperus rotundus bark, and natural copper.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	Each tablet weighs 0.3g

Shujin Huoxue Tablets
Ingredients	Safflower, Cibotium barometz, mistletoe, Zedoaria leaf, Millettia reticulata, Trachelospermum officinale, Lycopodiella ciliata, Cyperus rotundus, Cyperus rotundus bark, and natural copper.
Indication	Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.
Specifications	24s*3 boards
Manufacturer	Leshi Tongren Sanmenxia Pharmaceutical Co., Ltd.

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Guide of Nepetin

Description
Basic Attributes
Characteristics
Drug Information
Use and Manufacturing
Computed Properties
Related Drugs
Learn More Other Chemicals

Nepetin

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