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Dromostanolone propionate

Dromostanolone propionate structure

CAS No:
521-12-0
Formula:
C23H36O3
Chemical Name:
Dromostanolone propionate
Synonyms:
Androstan-3-one,2-methyl-17-(1-oxopropoxy)-,(2α,5α,17β)-;5α-Androstan-3-one,17β-hydroxy-2α-methyl-,propionate;(2α,5α,17β)-2-Methyl-17-(1-oxopropoxy)androstan-3-one;2MDTP;32379;Dromostanolone propionate;17β-Hydroxy-2α-methyl-5α-androstan-3-one propionate;Masterone;MDHT;2α-Methyldihydrotestosterone propionate;2α-Methyl-4,5-dihydrotestosterone propionate;2α-Methyl-17β-propionoxy-5α-androstan-3-one;Drostanolone propionate;17β-Hydroxy-2α-methylandrostan-3-one propionate;Drolban;Emdisterone;Masterid;Masteril;Permastril;2α-Methylandrostan-17β-ol-3-one propionate;Medrotestron propionate;Medrotestrone propionate;Medrotestrone propanoate;2α-Methyl-17β-hydroxy-5α-androstan-3-one 17-propionate;Masteron;Prometholone;1334-53-8;7241-34-1;51258-12-9
Categories:
Organic Chemistry > Carboxylic Acids and Derivatives

Description

Dromostanolone propionate (Drostanolone propionate) is a compound has antitumor activity against breast carcinoma[1]. Dromostanolone propionate inhibits the uptake of oestradiol-17ß by the tumour but has no apparent effect on the uptake by normal breast tissue [2]. Dromostanolone propionate implant pellet produces weight gains in animals and suppresses estrus in female animals[3].

Dromostanolone propionate is a steroid ester and a 3-oxo-5alpha-steroid. It has a role as an antineoplastic agent. It derives from a metholone.|Drolban is a DEA Schedule III controlled substance. Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|Dromostanolone Propionate is the propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness. (NCI)

Dromostanolone propionate Basic Attributes

Molecular Weight：

360.53

Exact Mass：

360.53

EC Number：

208-303-1

UNII：

X20UZ57G4O

DEA Code Number：

4000

NSC Number：

12198

DSSTox ID：

DTXSID1022972

NCI Thesaurus Code：

C1077

Characteristics

PSA：

43.37000

XLogP3：

5.67

Density：

1.1±0.1 g/cm3

Melting Point：

128 °C

Boiling Point：

445.9±45.0 °C at 760 mmHg

Flash Point：

190.5±28.8 °C

Refractive Index：

1.522

Storage Conditions：

Controlled Substance, -20?C Freezer

Toxicity：

LD50 subcutaneous in mouse: > 2gm/kg

Specific rotation：

D +24°

Toxicity

Toxicity Summary：

Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.

Drug Information

Drug Indication：

For use in females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.

Pharmacology：

Dromostanolone is a synthetic androgen, or male hormone, similar to testosterone. Dromostanolone works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.

Absorption：

Well absorbed following parenteral administration.

Mechanism of Action：

Dromostanolone is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, dromostanolone binds to the androgen receptor. This causes downstream genetic transcriptional changes. This ultimately causes retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of dromostanolone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.

MeSH Entry Terms：

2 alpha-methyldihydrotestosterone propionate

DEA Controlled Substances：

Drostanolone|Drolban, Masterid, Permastril|4000|Schedule III - Substances in the DEA Schedule III have a potential for abuse less than substances in Schedules I or II and abuse may lead to moderate or low physical dependence or high psychological dependence.|No

Dromostanolone propionate Use and Manufacturing

Uses

An anabolic steroid used as an antineoplastic.Pharmaceutical intermediates

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:360.5
XLogP3:5.3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:360.26644501
Monoisotopic Mass:360.26644501
Topological Polar Surface Area:43.4
Heavy Atom Count:26
Complexity:598
Defined Atom Stereocenter Count:8
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Dromostanolone propionate

Description
Basic Attributes
Characteristics
Toxicity
Drug Information
Use and Manufacturing
Computed Properties
Recommended Suppliers
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