ISOXANTHOHUMOL
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ISOXANTHOHUMOL
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CAS No:
521-48-2
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Formula:
C21H22O5
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Chemical Name:
ISOXANTHOHUMOL
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Synonyms:
ISOXANTHOHUMOL;4',7-DIHYDROXY-5-METHOXY-8-PRENYLFLAVANONE;2-(4-Hydroxyphenyl)-5-methoxy-7-hydroxy-8-(3-methyl-2-butenyl)-2,3-dihydro-4H-1-benzopyran-4-one;2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;4',7-Dihydroxy-5-methoxy-8-(3-methyl-2-butenyl)flavanone;4H-1-Benzopyran-4-one, 2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-buten-1-yl)-;Isoxanthohumol, 10 mM in DMSO
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CAS No:
Description
Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant,H. lupulus(hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.
ChEBI: Isoxanthohumol is a member of flavanones.
Characteristics
76
4.1
1.245±0.06 g/cm3(Predicted)
183 - 187°
585.8±50.0 °C(Predicted)
7.90±0.40(Predicted)
2-8°C
ISOXANTHOHUMOL Use and Manufacturing
Isoxanthohumol is a prenylated flavone isolated from hop. A chromane-like cyclic prenylflavonoids for neurological disorder therapy. Isoxanthohumol is a prenylated flavonoid phytoestrogen which is an apoptosis inducer in mature adipocytes