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Nalorphine hydrochloride

Nalorphine hydrochloride structure

CAS No:
57-29-4
Formula:
C19H21NO3.ClH
Chemical Name:
Nalorphine hydrochloride
Synonyms:
Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-(2-propen-1-yl)-,hydrochloride (1:1),(5α,6α)-;Morphinan-3,6α-diol,17-allyl-7,8-didehydro-4,5α-epoxy-,hydrochloride;Morphinan-3,6-diol,7,8-didehydro-4,5-epoxy-17-(2-propenyl)-,hydrochloride,(5α,6α)-;Naline hydrochloride;Nalorphine chloride;Nalorphine hydrochloride;N-Allylnormorphine hydrochloride;NIH 10124;881385-24-6;897948-67-3
Categories:
Analytical Chemistry > Standard

Description

A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.

Nalorphine hydrochloride Basic Attributes

Molecular Weight：

347.84

Exact Mass：

347.12900

EC Number：

200-321-8

UNII：

9FPE56Z2TW

DSSTox ID：

DTXSID3047847

HScode：

2939190000

Characteristics

PSA：

52.93000

XLogP3：

2.49420

Appearance：

white solid

Melting Point：

260-263 °C

Boiling Point：

493.6ºC at 760 mmHg

Flash Point：

11 °C

Water Solubility：

H2O: slightly soluble

Storage Conditions：

2-8°C

Toxicity：

LD50 s.c. in rats: 1460 mg/kg (Goldenthal)

Safety Information

Transport codes：

UN 1230 3/PG 2

wgk germany：

hazard class code：

22-39/23/24/25-23/24/25-11

safety instructions：

36/37/39-45-36/37-16-7

RTECS Number：

QC7710000

Marks：

Xn,T,F

Precautionary statement(s)：

P210-P260-P280-P301 + P310-P311

Hazard Statements：

H225-H301 + H311 + H331-H370

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Agents inhibiting the effect of narcotics on the central nervous system. (See all compounds classified as Narcotic Antagonists.)

MeSH Entry Terms：

Allylnormorphine

Nalorphine hydrochloride Use and Manufacturing

Uses

Narcotic antagonist.Controlled substance.

Use Classification：

Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:347.8
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:347.1288213
Monoisotopic Mass:347.1288213
Topological Polar Surface Area:52.9
Heavy Atom Count:24
Complexity:549
Defined Atom Stereocenter Count:5
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes