Fluphenazine hydrochloride
-
Fluphenazine hydrochloride
structure -
-
CAS No:
146-56-5
-
Formula:
C22H26F3N3OS.2ClH
-
Chemical Name:
Fluphenazine hydrochloride
-
Synonyms:
1-Piperazineethanol,4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-,hydrochloride (1:2);1-Piperazineethanol,4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]-,dihydrochloride;1-Piperazineethanol,4-[3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-,dihydrochloride;Anatensol;Fluphenazine dihydrochloride;Fluphenazine hydrochloride;10-[3-[4-(2-Hydroxyethyl)piperazinyl]propyl]-2-trifluoromethylphenothiazine dihydrochloride;1-(2-Hydroxyethyl)-4-[3-(2-trifluoromethyl-10-phenothiazinylpropyl]piperazine dihydrochloride;Moditen;Permitil;Permitil hydrochloride;Prolixin;Squibb 4918;4-[3-[2-(Trifluoromethyl)phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride;Liogen;Lyorodin;Fluorophenazine dihydrochloride;Tensofin;OMCA;Flufenazin;Fluphenazine chloride;Trancin;Mirenil;Siqualone;Dapotum;Valamina;Lyogen;Fludecan;Prolinate;2-(4-(3-(2-(Trifluoromethyl)-10H-phenothiazin-10-yl)propyl)piperazin-1-yl)ethanol dihydrochloride;36315-90-9
- Categories:
-
CAS No:
Description
Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist.
Fluphenazine hydrochloride is a member of phenothiazines. It has a role as an anticoronaviral agent.|Fluphenazine Hydrochloride is the hydrochloride salt of fluphenazine, a phenothiazine with antipsychotic activity and potential antineoplastic activity. Fluphenazine blocks postsynaptic dopamine D2 receptors in the limbic system, cortical system and basal ganglia, resulting in a reduction of schizophrenia-associated hallucinations and delusions. In addition, as a serotonin antagonist, this agent may inhibit lymphocyte and myeloma cell proliferation by blocking 5-hydroxytrptamine type 1B (5-HT type 1B) receptors for serotonin.|A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.
Characteristics
55.2
5.85290
Off-white solid
235-237 °C
568.3°C at 760 mmHg
297.5ºC
Soluble in DMSO and methanol.
-20°C Freezer
9.41E-14mmHg at 25°C
197.5 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
Ⅲ
6.1
UN2811
36/37/38-20/21/22
26-36/37/39-36
TL9800000
Xn
P201-P301 + P310-P308 + P313
H301-H360
Drug Information
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus. (See all compounds classified as Antipsychotic Agents.)|Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)
Flufenazin
Fluphenazine hydrochloride Use and Manufacturing
Antipsychotic
Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients
Computed Properties
Molecular Weight:510.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:6
Exact Mass:509.1282236
Monoisotopic Mass:509.1282236
Topological Polar Surface Area:55.2
Heavy Atom Count:32
Complexity:544
Covalently-Bonded Unit Count:3
Compound Is Canonicalized:Yes
Drug Function and Efficacy
The antipsychotic effect is mainly related to its blocking of dopamine receptors (DA11) in the brain, inhibiting the ascending activation system of the reticular formation and having a sedative effect, but its antiemetic and blood pressure lowering effects are weaker.
Registered Holders
-
AURORE LIFE SCIENCES PRIVATE LTD
Active
United States
-
MSN LIFE SCIENCES PRIVATE LTD
Active
United States
-
ENALTEC LABS PRIVATE LTD
Active
United States
Learn More Other Chemicals
-
4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-, hydrochloride (1:1)
67652-33-9
-
Cyclopropanecarboxylic acid, 1-amino-2-ethenyl-, ethyl ester, hydrochloride (9CI)
681807-60-3
-
CYCLOPENTYL-(3,4,5-TRIMETHOXY-BENZYL)-AMINE HYDROCHLORIDE
1052525-88-8
-
2-Cyclopropylbenzenemethanamine hydrochloride Formula
118184-64-8
-
Des[4-(2-cycloproylMethoxy)] Betaxolol Hydrochloride Formula
464877-45-0
-
Ethanamine, 2-(decylthio)-, hydrochloride (1:1) Formula
36362-09-1
-
4,7-Dichloro-2-propylquinoline hydrochloride Structure
1204812-22-5
-
6,7-Dichloro-4-hydrazino-2-methylquinoline hydrochloride Structure
1170377-12-4
-
What is 2,8-Diazaspiro[4.5]decan-1-one, 2-[(4-bromophenyl)methyl]-, hydrochloride (1:1)
832710-56-2
-
What is 6,7-Dichloro-4-hydrazinoquinoline hydrochloride
1171843-02-9