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Osalmid

Osalmid structure

CAS No:
526-18-1
Formula:
C13H11NO3
Chemical Name:
Osalmid
Synonyms:
Benzamide,2-hydroxy-N-(4-hydroxyphenyl)-;Salicylanilide,4′-hydroxy-;2-Hydroxy-N-(4-hydroxyphenyl)benzamide;Driol;Driol-Labaz;Enidran;N-(p-Hydroxyphenyl)salicylamide;4′-Hydroxysalicylanilide;Oxaphenamide;Salmidochol;p-Hydroxyphenylsalicylamide;PHPS;p′-Hydroxysalicylanilide;N′-Salicyloyl-p-aminophenol;N-(4-Hydroxyphenyl)salicylamide;Osalmid;Osalmide;Auxobil;Bilene;Oxaphenamid;Dribazil;L 1718;Bilocol;Li Dan Feng;WR 17456;Fumispore;Oksafenamide;Saryuurin;Jestmin;Kanochol;Yoshicol;NSC 93960
Categories:
Organic Chemistry > Amides

Description

Osalmid is a ribonucleotide reductase small subunit M2 (RRM2) targeting compound; suppresses ribonucleotide reductase activity with an IC50 of 8.23 μM.

Osalmid is an organic molecular entity.|Osalmid is under investigation in clinical trial NCT03670173 (Safety and Efficacy Assessments of Osalmid in Multiple Myeloma).

Osalmid Basic Attributes

Molecular Weight：

229.23

Exact Mass：

229.23

EC Number：

208-385-9

UNII：

89741L759Z

NSC Number：

93960

DSSTox ID：

DTXSID0042244

HScode：

2924299090

Characteristics

PSA：

69.6

XLogP3：

2.9

Density：

1.4±0.1 g/cm3

Melting Point：

179 °C

Boiling Point：

350.8°C at 760 mmHg

Flash Point：

165.9±23.7 °C

Refractive Index：

1.711

Toxicity：

LD50 oral in rat: 6702mg/kg

Safety Information

hazard class code：

22-36/37/38-42/43

safety instructions：

26-36/37

Marks：

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

Drug Information

MeSH Entry Terms：

4'-hydroxysalicylanilide

Osalmid Use and Manufacturing

Methods of Manufacturing

General procedure: To the reaction vessel were added 0.07 mol of p-aminophenol, 0.076 mol of 2-hydroxy-benzamide and 80 ml of ethyl acetate, and the stirring rate was controlled at150rpm, slowly adding stannous chloride 0.031mol, the solution becomes darker color, add finished slowly heated to 170 , the reaction 6h, 2.1kPa vacuum distillationDistill part of ethyl acetate, lower the temperature of the solution to 38 , pour the reactant into 500ml mass fraction of 23percent sodium bisulfite solution, Adding water 33percent oxalic acid solution, adjusting the pH value to 4, precipitating the solid, separating the substance from the solution, Was recrystallized from 87percent ethylenediamine solution to obtain 13.47 g of white solid N-p-hydroxyphenyl salicylamide in 84percent yield.

Uses

It is used to treat acute and chronic cholecystitis, gallstone calculi, and at the same time it has a yellowing bile effect

Computed Properties

Molecular Weight:229.23
XLogP3:2.9
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:229.07389321
Monoisotopic Mass:229.07389321
Topological Polar Surface Area:69.6
Heavy Atom Count:17
Complexity:261
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

4-Aminophenol

Salicylic acid

Drug Function and Efficacy

It increases liver blood flow, improves liver function, and significantly increases the water content in bile. Its choleretic effect is stronger than that of dehydrocholic acid, and it can relax the sphincter of Oddi and lower blood cholesterol.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Salicylic acid tablets
Ingredients	The main ingredients of this product and their chemical names: The main ingredient of this product is salicylic acid phenol, and its chemical name is 4-hydroxysalicylic acid anilide.
Indication	Not yet clear.
Specifications	0.25g

Salicylate Capsules
Ingredients	The main component of this product is salicylamine, and its chemical name is 4-hydroxy salicylanilide. Its structural formula is C13H11NO3 and its molecular weight is 229.24.
Indication	Not yet clear.
Specifications	0.25g
Manufacturer	Jilin Junhong Pharmaceutical Co., Ltd.

Salicylic acid tablets
Ingredients	The main ingredients of this product and their chemical names: The main ingredient of this product is salicylic acid phenol, and its chemical name is 4-hydroxysalicylic acid anilide.
Indication	Not yet clear.
Specifications	0.25g

See More Related Drugs

Registered Holders

Shanxi Zhendong Anxin Biopharmaceutical Co., Ltd.

China
Active
Jilin Aodong--Taonan Pharnalentical Company Ltd

China
Active
Yangzhou NO.3 Pharmacitical Manufacture Co., Ltd.

China
Active

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