Salicylic acid
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Salicylic acid
structure -
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CAS No:
69-72-7
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Chemical Name:
Salicylic acid
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Synonyms:
Benzoic acid,2-hydroxy-;Salicylic acid;2-Hydroxybenzoic acid;o-Hydroxybenzoic acid;Retarder W;Salicylic acid collodion;Rutranex;Salonil;Psoriacid-S-Stift;Phenol-2-carboxylic acid;2-Hydroxybenzenecarboxylic acid;2-Carboxyphenol;o-Carboxyphenol;Duoplant;Salicylic Acid Soap;337;Advanced Pain Relief Callus Removers;380;Dr. Scholl's Callus Removers;311;51;334;Stri-Dex;Compound W;Freezone;Clear away Wart Remover;171;Duofil Wart Remover;Saligel;Advanced Pain Relief Corn Removers;Dr. Scholl's Wart Remover Kit;Ionil Plus;K 557;Ionil;K 537;Dr. Scholl's Corn Removers;NSC 180;Trans-Ver-Sal;Salvona Nanosal;Verrugon;7681-06-3;8052-31-1;1186130-36-8
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CAS No:
Description
Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation.
Characteristics
57.53
2.3
White to off-white crystalline powder
1.443 g/cm3 @ Temp: 20 °C
157-159 °C
211 °C (approx) @ Press: 20 Torr
157 °C
1.565
H2O: 1.8 g/L (20 ºC)
Store at RT.
1 mm Hg ( 114 °C)
4.8 (vs air)
LD50 i.v. in mice: 500 mg/kg (Sota)
Lower 1.1% @ 392 deg F (200 deg C)
DUST IS EXPLOSIVE IN AIR .
Safety Information
NONH for all modes of transport
1
R22; R36/37/38; R41
S26-S39-S37/39
VO0525000
Xn
Separated from strong oxidants.
Stable. Substances to be avoided include oxidizing agents, strong bases, iodine, fluorine. Combustible. Sensitive to light.
P280-P301 + P312 + P330-P305 + P351 + P338 + P310
H302-H318
Salicylic acid Use and Manufacturing
Phenol and sodium hydroxide reaction to produce sodium phenol, distilled dehydration, carbon dioxide through the carboxylation reaction, obtained salicylic acid sodium salt, and then acidification of sulfuric acid, and crude. The crude product is refined by sublimation. Raw material consumption quota: phenol (98%) 704 kg / t, caustic soda (95%) 417 kg / t, sulfuric acid (95%) 500 kg / t, carbon dioxide (99%) 467 kg / t. The method is divided into atmospheric pressure and medium pressure method.
1. Salicylic Acid is an Impurity of Acetylsalicylic Acid (A187780). Acetylsalicylic acid Impurity B.
2. Non-steroidal anti-inflammatory drugs
Computed Properties
Molecular Weight:138.12
XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:138.031694049
Monoisotopic Mass:138.031694049
Topological Polar Surface Area:57.5
Heavy Atom Count:10
Complexity:133
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Price Analysis
- Data: 2026-07-17
- Price: 12500.00Yuan/ton
- Change: 0
Drug Function and Efficacy
Keratin dissolving softener with antibacterial and antipruritic effects
Registered Holders
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JQC HUAYIN PHARMACEUTICAL CO LTD
Active
United States
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NOVACYL
Active
France
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Jilin Jinheng Pharmaceutical Co., Ltd.
Active
China
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