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2-Hydroxyquinoline

2-Hydroxyquinoline structure

CAS No:
59-31-4
Formula:
C9H7NO
Chemical Name:
2-Hydroxyquinoline
Synonyms:
2(1H)-Quinolinone;Carbostyril;2-Quinolinol;α-Hydroxyquinoline;2-Hydroxyquinoline;o-Aminocinnamic acid lactam;2(1H)-Quinolone;α-Quinolone;2-Quinolone;2-Quinolinone;2-Oxo-1,2-dihydroquinoline;1,2-Dihydro-2-oxoquinoline;1H-Quinolin-2-one;NSC 156783;NSC 554;NSC 97217;493-62-9
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

white to light purple or purple-brownish powder

Quinolin-2-ol is a monohydroxyquinoline carrying a hydroxy substituent at position 2. It is an intermediate metabolite produced duting the microbial degradation of quinoline. It has a role as a bacterial xenobiotic metabolite. It is a tautomer of a quinolin-2(1H)-one.

2-Hydroxyquinoline Basic Attributes

Molecular Weight：

145.16

Exact Mass：

145.16

BRN：

2855

EC Number：

274-516-1

UNII：

803BHY7QWU

NSC Number：

156783|554

DSSTox ID：

DTXSID1058769

HScode：

2933499090

Characteristics

PSA：

29.1

XLogP3：

1.3

Appearance：

White to light purple or purple-brownish Powder

Density：

1.3±0.1 g/cm3

Melting Point：

199.5 °C

Boiling Point：

346.7°C at 760 mmHg

Flash Point：

167.2±20.4 °C

Refractive Index：

1.691

Water Solubility：

alcohol: soluble (lit.)

Storage Conditions：

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Vapor Pressure：

5.67E-05mmHg at 25°C

Safety Information

Packing level：

I; II; III

Transport codes：

2811

wgk germany：

hazard class code：

36/37/38-20/21/22-41-37/38-22

safety instructions：

26-37/39-36

RTECS Number：

FG7175000

Marks：

Xn,Xi

Hazard note：

Harmful/Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261-P280-P305 + P351 + P338

Hazard Statements：

H302-H315-H318-H335

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 38 companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H302 (96.24%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 133 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

2-hydroxyquinoline

2-Hydroxyquinoline Use and Manufacturing

Uses

Used as pharmaceutical intermediate

Manufacturing Info：

2(1H)-Quinolinone: INACTIVE

Computed Properties

Molecular Weight:145.16
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Exact Mass:145.052763847
Monoisotopic Mass:145.052763847
Topological Polar Surface Area:29.1
Heavy Atom Count:11
Complexity:198
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Ethyl 4,4,4-trifluoroacetoacetate

Ethanol

Acetic acid

Hydrogen peroxide

Recommended Suppliers of 2-Hydroxyquinoline

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

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2-Quinolinol

CAS No.: 59-31-4

Content: 99.00%

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Hangzhou KieRay Chem Co.,LTD Contact Supplier

CN
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Manufactory Supplier of fine chemicals,pharmaceutical materials

2-Quinolinol

CAS No.: 59-31-4

Grade: industrial Grade

Content: 98%

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