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Tolazoline hydrochloride

Tolazoline hydrochloride structure

CAS No:
59-97-2
Formula:
C10H12N2.ClH
Chemical Name:
Tolazoline hydrochloride
Synonyms:
1H-Imidazole,4,5-dihydro-2-(phenylmethyl)-,hydrochloride (1:1);2-Imidazoline,2-benzyl-,monohydrochloride;1H-Imidazole,4,5-dihydro-2-(phenylmethyl)-,monohydrochloride;Arterodyl;Benzazoline hydrochloride;Imidaline hydrochloride;Priscoline hydrochloride;Tolavad;Tolazoline chloride;Tolazoline hydrochloride;Tolpal;2-Benzyl-4,5-dihydroimidazole hydrochloride;2-Benzyl-2-imidazoline hydrochloride;2-Benzylimidazoline hydrochloride;Totazoline;Lambral;Vaso-Dilatan;2-Benzyl-4,5-dihydro-1H-imidazole hydrochloride;7380-28-1;245547-27-7
Categories:
Active Pharmaceutical Ingredients > Circulatory System Drugs

Description

Tolazoline(NSC35110; Imidaline) Hcl is a non-selective competitive α-adrenergic receptor antagonist.IC50 value:Target: α-adrenoceptor antagonistTolazoline can be synthesized by the heterocyclation of the ethyl ester of iminophenzylacetic acid with ethylene diamine, which forms the desired product. The structure of tolazoline is strikingly similar to α-adrenergic agonists, which are antiedema sympathomimetics.

Tolazoline hydrochloride is a member of benzenes.|A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.

Tolazoline hydrochloride Basic Attributes

Molecular Weight：

196.68

Exact Mass：

196.076721

EC Number：

200-447-3

UNII：

E669Z6S1JG

NSC Number：

757353

DSSTox ID：

DTXSID9021718

HScode：

2933290090

Characteristics

PSA：

24.4

XLogP3：

1.79720

Appearance：

White to almost white Crystalline Powder

Density：

1.09g/cm3

Melting Point：

174 °C

Boiling Point：

338.2ºC at 760mmHg

Flash Point：

158.3ºC

Storage Conditions：

-20°C Freezer, Under Inert Atmosphere

Toxicity：

Oral-large LD50: 1200 mg/kg; Oral-Mouse LD50: 400 mg/kg

Flammability characteristics：

Combustion produces toxic nitrogen oxides and hydrogen chloride fumes; drug side effects; rapid heartbeat, sweating, bleeding from 12 fingers, small intestine, ulcers

Collision Cross Section：

135.1 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Safety Information

Transport codes：

2811

hazard class code：

safety instructions：

Marks：

Storage features：

Ventilated, low temperature and dry

Stability/Shelf Life：

Hygroscopic

Precautionary statement(s)：

P301 + P312 + P330-P305 + P351 + P338

Hazard Statements：

H302-H315-H319-H335

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 45 companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

highly toxic

Drug Information

MeSH：

Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. (See all compounds classified as Adrenergic alpha-Antagonists.)|Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS. (See all compounds classified as Antihypertensive Agents.)|Drugs used to cause dilation of the blood vessels. (See all compounds classified as Vasodilator Agents.)

MeSH Entry Terms：

Benzalolin

Tolazoline hydrochloride Use and Manufacturing

Uses

adrenergic blocker

Manufacturing Info：

1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-, hydrochloride (1:1): INACTIVE

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:196.67
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:196.0767261
Monoisotopic Mass:196.0767261
Topological Polar Surface Area:24.4
Heavy Atom Count:13
Complexity:169
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Recommended Suppliers of Tolazoline hydrochloride

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
2 YRS

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Tolazoline hydrochloride

Unit Price: $1 /KG EXW

CAS No.: 59-97-2

Grade: pharmaceutical grade

Content: 99%

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HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

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Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Tolazoline hydrochloride

CAS No.: 59-97-2

Content: 99.00%

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