2,4,6-Trimethylphenol

136.194

136.19

208-419-2

FPZ32614N6

68321|5353

DTXSID7022049

NEEDLES

2907199090

20.2

2.7

DryPowder; Liquid

1.0±0.1 g/cm3

73 °C

220 °C

96.7±8.4 °C

1.536

1.008g/L(25 ºC)

Store in a cool, dry place. Store in a tightly closed container. Corrosives area.

0.05 mm Hg at 25 deg C

pKa = 10.88 at 25 °C

SUBLIMES AT 221 °C|Cyclohexane/water partition coefficient 1.24 (log)|UV: 45 (Friedel and Orchin, Ultraviolet Spectra of Aromatic Compounds, John Wiley & Sons, New York) /Phenol, 2,3,5-trimethyl/

Ⅲ

8

2430

2

8

S26-S36/37/39-S45-S24/25

OX6590000

C:Corrosive;

P260-P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

H314-H411

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.|The following wastewater treatment technologies have been investigated for trimethylphenol: Activated carbon. /Trimethylphenol/

|Warning|H315: Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P321, P332+P313, and P362

ORGANIC CANISTER MASK; FACE SHIELD; RUBBER GLOVES; OTHER PROTECTIVE CLOTHING TO PREVENT CONTACT WITH SKIN. /DIMETHYL PHENOL/|/IN FIRE CONDITIONS/ WEAR GOGGLES AND SELF CONTAINED BREATHING APPARATUS. /DIMETHYL PHENOL/|Wear appropriate chemical protective gloves, boots and goggles. /Dimethyl phenol/

2,4,6-Trimethylphenol was identified, not quantified, in the effluent of a petroleum refinary and publicly owned treatment works between Nov 1, 1979 and Nov 1, 1981 at unspecified locations in the US(1).

Estimated concentration of 2,4,6-trimethylphenol in air samples collected during Nov 1982 at the pilot-scale shale oil wastewater treatment plant of Occidental Oil Shale in Logan Wash, CO: 3 ug/cu m= indoor air, 0.6 ug/cu m= outdoor air near the facility(1). Air above shale oil wastewater held in closed containers contained C3 alkylphenol isomers (specific compounds not identified) at an average concentration of 1.9 ug per ml of air above 1 ml of wastewater. The wastewater was collected from Occidental Shale Oil in Logan Wash, CO during Dec 1982(1).

LD50 Mouse oral 10 g/kg

2,4,6-Trimethylphenol's production and use in petroleum processing(1) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 700(SRC), determined from a log Kow of 2.73(2) and a regression-derived equation(3), indicates that 2,4,6-trimethylphenol is expected to have low mobility in soil(SRC). Volatilization of 2,4,6-trimethylphenol from moist soil surfaces is expected to occur slowly(SRC) given an estimated Henry's Law constant of 3.1X10-6 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 0.05 mm Hg(4), and water solubility, 1,010 mg/l at 25 °C(5). 2,4,6-Trimethylphenol is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). 2,4,6-Trimethylphenol is expected to biodegrade slowly in soils(SRC) based on a theoretical BOD of 7 percent in the Japanese MITI test during a 4 week incubation period(6).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 700(SRC), determined from a log Kow of 2.73(2) and a regression-derived equation(3), indicates that 2,4,6-trimethylphenol is expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is expected to occur(3) based upon an estimated Henry's Law constant of 3.1X10-6 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 0.05 mm Hg(4), and water solubility, 1,010 mg/l at 25 °C(5). Volatilization half-lives for a model river and model lake are 14 and 104 days, respectively(SRC), using an estimation method(3). 2,4,6-Trimethylphenol is expected to undergo photolysis in sunlit surface waters, with typical half-lives of about 4-11 hours(6). According to a classification scheme(7), BCF values of 3-10 measured in carp(8), suggest that bioconcentration in aquatic organisms is low(SRC). 2,4,6-Trimethylphenol, at an initial concn of 0.09 mg/l, underwent no degradation when incubated in coal tar-contaminated groundwater in an anaerobic digester for 8 weeks(9).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,4,6-trimethylphenol, which has a vapor pressure of 0.05 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,4,6-trimethylphenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 hours(SRC) from its estimated rate constant of 2.4X10-11 cu cm/molecule-sec at 25 °C(SRC), determined from a fragment constant estimation method(3).

The rate constant for the vapor-phase reaction of 2,4,6-trimethylphenol with photochemically-produced hydroxyl radicals has been estimated as 2.4X10-11 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 16 hours at an atmospheric concn of 5X10+5 hydroxyl radicals per cu cm(1). 2,4,6-Trimethylphenol is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(2). Based on experimental data, the photooxidation half-life of 2,4,6-trimethylphenol in mid-latitude surface waters during mid-summer was estimated to be 4.3 hours at water surfaces and 11 hours at a depth of 1 m(3). The photooxidation half-lives of 2,4,6-trimethylphenol in surface waters from Oregon and California were measured as 1.7-3.6 hours, while the half-lives in sub-surface waters were measured as 3.6-6 hours(4).

8.51|BCF values of 6-10 were measured in carp exposed to 0.2 mg/l of 2,4,6-trimethylphenol over 6 weeks and BCF values of 3-8 were measured for carp exposed to 0.02 mg/l for 6 weeks(1). According to a classification scheme(2), these BCF values suggest that the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of 2,4,6-trimethylphenol is estimated as 700(SRC), using a log Kow of 2.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2,4,6-trimethylphenol is expected to have low mobility in soil(SRC).

The Henry's Law constant for 2,4,6-trimethylphenol is estimated as 3.1X10-6 atm-cu m/mole(SRC) from its experimental values for vapor pressure, 0.05 mm Hg(1), and water solubility, 1,010 mg/l(2). This Henry's Law constant indicates that 2,4,6-trimethylphenol is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as approximately 14 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 104 days(SRC). 2,4,6-Trimethylphenol's estimated Henry' Law constant(1,2) indicates that volatilization from moist soil surfaces may occur(SRC). 2,4,6-Trimethylphenol is not expected to volatilize from dry soil surfaces(SRC) based upon the vapor pressure of this compound(1).

GROUNDWATER: 2,4,6-Trimethylphenol was detected in groundwater in the vicinity of the wood treatment facilities of the American Creosote Works in Pensacola, FL, 5 sampling sites, 1984, detection limit 0.005 ppm, max concn detected (sampling depth): 0.23 ppm (6 m), 0.05 ppm (12 m), 0.17 ppm (18 m), 0.09 ppm (24 m), and not detected (30 m)(1). 2,4,6-Trimethylphenol was detected in groundwater at a coal and gasification plant in Seattle, WA at a concn of 0.18 mg/l(2). 2,4,6-Trimethylphenol was identified, not quantified, in the Rhine River, Netherlands(3). 2,4,6-Trimethylphenol was detected in groundwater in St Louis Park, MN at a concn of 0.45 mg/l(4).

NIOSH (NOES Survey 1981-1983) has statistically estimated that 93 workers (56 of these are female) are potentially exposed to 2,4,6-trimethylphenol in the US(1). Occupational exposure to 2,4,6-trimethylphenol may occur through inhalation and dermal contact with this compound at workplaces where 2,4,6-trimethylphenol is produced or used(SRC).

HYDROXYLATION OF AROMATIC HYDROCARBONS WAS STUDIED FOLLOWING THEIR ORAL ADMINISTRATION TO RATS WHICH ALSO RECEIVED A PURIFIED DIET CONTAINING NEOMYCIN TO REDUCE THE LEVELS OF NORMALLY OCCURRING SIMPLE URINARY PHENOLS. PHENOLIC METABOLITES WERE QUANTITATIVELY ESTIMATED IN HYDROLYZED URINE SAMPLES BY GAS CHROMATOGRAPHY. /1,3,5-TRIMETHYLBENZENE/ ADMINISTERED AT A DOSE OF 100 MG/KG WAS METABOLIZED TO 2,4,6-TRIMETHYLPHENOL TO THE EXTENT OF 0.4% OF THE DOSE GIVEN.

0.05 Days

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Administer activated charcoal ... . Dilution may be contraindicated because it may increase absorption. Do not use emetics ... . Cover skin burns with dry sterile dressings after decontamination ... . /Phenols and Related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive-pressure ventilation techniques with a bag-valve-mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W TKO /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Consider vasopressors for hypotension with a normal fluid volume. Watch for signs of fluid overload ... . Administer 1% solution methylene blue if patient is symptomatic with severe hypoxia, cyanosis, and cardiac compromise not responding to oxygen. ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Phenols and Related Compounds/

Contact allergy to phenol formaldehyde resins was studied in Sweden. A p-tert-butylphenol/formaldehyde resin (resin 3) and another phenol formaldehyde resin called resin 1 were used in patch tests on 1220 patients over the course of a year. The last 440 patients were also tested with a second phenol formaldehyde resin, designated resin 2. Patients reacting to at least one of the resins were also patch tested with 2-methylphenol, 4-methylol-phenol, 2,4,6-trimethylphenol, formaldehyde, phenol, and p-tert-butylphenol. ... Three patients reacted to 4-methylol-phenol and two reacted to all three methylol phenols. All of these patients had positive reactions to resin 3. Most patients positive to resin 1 were negative to methylol phenols.

2,4,6-trimethylphenol

All other chemical product and preparation manufacturing|Phenol, 2,4,6-trimethyl-: ACTIVE

ISOLATION OF THE REFERENCE PHENOLS (INCLUDING 2,4,6-TRIMETHYLPHENOL) FROM INTERFERING COMPOUNDS GAVE RELATIVE RECOVERY OF 90-100%. SEPARATION OF PHENOLS INTO INDIVIDUAL COMPONENTS WAS PERFORMED ON POLAR PACKINGS AS WELL AS ON REVERSE PHASE PACKINGS. QUANTITATIVE ANALYSIS WAS CARRIED OUT ON A PREPACKED ZORBAX ODS COLUMN USING A UV PHOTOMETER OF 254 NM WAVELENGTH. THE CONCENTRATIONS OF THE PHENOLS DETERMINED BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WERE 1-10 PPM OR 0.03-0.18 MG/CU M OF AUTO EXHAUST.|GAS CHROMATOGRAPHY WITH WALL-COATED OPEN TUBULAR GLASS CAPILLARY COLUMNS HAS BECOME THE MOST WIDELY USED METHOD OF ANALYSIS FOR MONO- AND DIHYDROXYBENZENES OR PHENOLS (INCLUDING 2,4,6-TRIMETHYLPHENOL) IN TOBACCO SMOKE AND PYROLYZATES.|Two general methods for the identification and measurement of organic compounds in water are compared. One method employs packed column chromatography and the other fused silica capillary column chromatography. Both methods give mean relative std deviations for concn measurements of about 20%.

Food additives -> Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT; -> JECFA Functional Classes|Flavoring Agents -> JECFA Flavorings Index

Flavoring Agents|Flavouring Agent -> FLAVOURING_AGENT;