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Retinol, acetate

Retinol, acetate structure

CAS No:
127-47-9
Formula:
C22H32O2
Chemical Name:
Retinol, acetate
Synonyms:
Retinol,acetate;Retinol,acetate,all-trans-;Myvak;Myvax;Retinyl acetate;all-trans-Vitamin A acetate;all-trans-Retinyl acetate;Vitamin A acetate;trans-Retinyl acetate;Vitamin A1 acetate;Arovit;Ro 1-5275;all-trans-Retinol acetate;trans-Retinol acetate;NSC 122045;NSC 122760;Rovimix A 1000;Retinol acetate;Dry Vitamin A Acetate 325CWS/A;7095-40-1;11098-51-4;13116-20-6;80180-27-4
Categories:
Cosmetic Ingredient > Skin Conditioning

Description

CrystallineRetinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

Retinyl acetate is an acetate ester. It derives from an all-trans-retinol.|Retinyl Acetate is a naturally-occurring fatty acid ester form of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Retinyl acetate binds to and activates retinoid receptors, inducing cell differentiation and decreasing cell proliferation. This agent also inhibits carcinogen-induced neoplastic transformation in some cancer cell types and exhibits immunomodulatory properties. (NCI04)

Retinol, acetate Basic Attributes

Molecular Weight：

328.49

Exact Mass：

328.49

BRN：

1915439

EC Number：

204-844-2

UNII：

3LE3D9D6OY

NSC Number：

758220|122760|122045

DSSTox ID：

DTXSID6021240

NCI Thesaurus Code：

C1216

HScode：

29362100

Characteristics

PSA：

26.3

XLogP3：

7.39

Appearance：

solid or viscous liquid

Density：

1.0474 (rough estimate)

Melting Point：

57-58 °C

Boiling Point：

406.22°C (rough estimate)

Flash Point：

14℃

Refractive Index：

1.547-1.555

Water Solubility：

H2O: soluble ;absolute ethanol: 25 mg/mL

Storage Conditions：

2-8°C

Vapor Pressure：

0mmHg at 25°C

Toxicity：

LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)

Safety Information

Transport codes：

UN1170 - class 3 - PG 2 - Ethanol

wgk germany：

hazard class code：

38-63-36/37/38-53-61-11

safety instructions：

36/37-45-37/39-26-53-16

RTECS Number：

VH6825000

Marks：

Xn,Xi,T,F

Precautionary statement(s)：

P201-P308 + P313

Hazard Statements：

H360-H413

GHS Classification：

|Danger|H315 (68.84%): Causes skin irritation [Warning Skin corrosion/irritation]|P201, P202, P264, P273, P280, P281, P302+P352, P308+P313, P321, P332+P313, P362, P405, and P501|Aggregated GHS information provided by 354 companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH：

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. (See all compounds classified as Adjuvants, Immunologic.)|Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved. (See all compounds classified as Anticarcinogenic Agents.)

MeSH Entry Terms：

9-cis-retinyl acetate

Retinol, acetate Use and Manufacturing

Uses

Essential micronutrient

Manufacturing Info：

Retinol, acetate: ACTIVE

Use Classification：

Lipids -> Prenol Lipids [PR] -> Isoprenoids [PR01] -> Retinoids [PR0109]|Cosmetics -> Skin conditioning

Computed Properties

Molecular Weight:328.5
XLogP3:6.3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:328.240230259
Monoisotopic Mass:328.240230259
Topological Polar Surface Area:26.3
Heavy Atom Count:24
Complexity:596
Defined Bond Stereocenter Count:4
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It promotes growth and maintains the normal functions of epithelial tissues such as skin, conjunctiva, and cornea. It also participates in the synthesis of rhodopsin and enhances the photosensitivity of the retina. It participates in many oxidation processes in the body, especially the oxidation of unsaturated fatty acids. When vitamin A is deficient, growth stops, bones grow poorly, reproductive function declines, skin becomes rough and dry, cornea softens, and dry eye and night blindness occur.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Vitamin A soft capsule
Ingredients	The main ingredient of this product is vitamin A acetate.
Indication	Sucralfate, aluminum hydroxide, neomycin, and cholestyramine can affect the absorption of vitamins A and E. Oral contraceptives may increase the concentration of plasma vitamin A and accelerate the metabolism of vitamin E. Avoid using this product with dicoumarol and its derivatives to prevent the vitamin E in them from interacting with them and causing hypoprothrombinemia.
Specifications	25000 units
Manufacturer	Zhejiang Medicine Co., Ltd.

Centrum Silver Tablets
Ingredients	This product is a compound preparation. Each tablet contains: 4000 IU of vitamin A (acetate); 80 mg of potassium; 2000 IU of beta-carotene (equivalent to vitamin A); 72 mg of chlorine; 400 IU of vitamin D; 100 mg of magnesium; 45 IU of vitamin E; 9 mg of iron; 11.5 mg of vitamin B1; 2 mg of copper; 1.7 mg of vitamin B2; 15 mg of zinc; 3 mg of vitamin B6; 2.5 mg of manganese; 60 mg of vitamin C; and 150 micrograms of iodine.
Indication	1. Antacids can affect the absorption of vitamin A in this product, so they should not be taken together. 2. It should not be used with drugs containing large amounts of magnesium and calcium to avoid causing hypermagnesemia and hypercalcemia. 3. If used with other drugs at the same time, drug interactions may occur. Please consult a physician or pharmacist for details.
Specifications	Compound
Manufacturer	Haleon (Suzhou) Pharmaceutical Co., Ltd.

Vitamin A soft capsule
Ingredients	Chemical name: 3,7-dimethyl-9-(2,6,6-trimethyl-l-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol acetate (vitamin A acetate)
Indication	1. Aluminum hydroxide can reduce bile acid in the upper part of the small intestine, affecting the absorption of vitamin A. 2. Oral contraceptives can increase the concentration of plasma vitamin A. 3. Sucralfate can interfere with the absorption of vitamin A. 4. When used in combination with vitamin E, it can promote the absorption of vitamin A, increase the storage in the liver, accelerate utilization and reduce toxicity, but a large amount of vitamin E can deplete the storage of vitamin A in the body. 5. If you are taking other medicines, please consult a doctor or pharmacist before using this product.
Specifications	25,000 units
Manufacturer	Nanjing Haijing Pharmaceutical Co., Ltd.

See More Related Drugs

Registered Holders

DSM Vitamins Trading (SHANGHAI) Co., Ltd.

China
Active
BASF SE

European Union
Active
DSM-FIRMENICH SWITZERLAND AG

European Union
Active

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Guide of Retinol, acetate

Description
Basic Attributes
Characteristics
Safety Information
Drug Information
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Learn More Other Chemicals

Retinol, acetate

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