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1-Hexacosanol

1-Hexacosanol structure

CAS No:
506-52-5
Formula:
C26H54O
Chemical Name:
1-Hexacosanol
Synonyms:
1-Hexacosanol;Ceryl alcohol;Cerylic alcohol;n-Hexacosanol;Hexacosyl alcohol;Hexacosanol;Cerotyl alcohol;NSC 4058
Categories:
Organic Chemistry > Carboxylic Acids and Derivatives

Description

white powder

OtherSolid

Hexacosan-1-ol is a very long-chain primary fatty alcohol that is hexacosane in which a hydrogen attached to one of the terminal carbons is replaced by a hydroxy group. It has a role as a plant metabolite. It is a fatty alcohol 26:0 and a very long-chain primary fatty alcohol. It derives from a hydride of a hexacosane.

1-Hexacosanol Basic Attributes

Molecular Weight：

382.717

Exact Mass：

382.71

EC Number：

208-044-4

UNII：

M7SD300NNB

NSC Number：

4058

DSSTox ID：

DTXSID3027162

HScode：

2905199090

Characteristics

PSA：

20.2

XLogP3：

12.56

Appearance：

OtherSolid

Density：

0.8±0.1 g/cm3

Melting Point：

80 °C

Boiling Point：

175 °C @ Press: 0.02 Torr

Flash Point：

139.2±6.0 °C

Refractive Index：

1.457

Storage Conditions：

2-8ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

S22-S24/25

Drug Information

MeSH Entry Terms：

1-hexacosanol

1-Hexacosanol Use and Manufacturing

Uses

Processing aids, specific to petroleum production

Manufacturing Info：

Oil and gas drilling, extraction, and support activities|1-Hexacosanol: ACTIVE

Use Classification：

Fatty Acyls [FA] -> Fatty alcohols [FA05]

Computed Properties

Molecular Weight:382.7
XLogP3:12.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:24
Exact Mass:382.417466342
Monoisotopic Mass:382.417466342
Topological Polar Surface Area:20.2
Heavy Atom Count:27
Complexity:238
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Drug Function and Efficacy

1. Pharmacological action: Policosanol is a mixture of eight higher fatty alcohols extracted from cane wax. Animal experiments have found that Policosanol can reduce the levels of cholesterol and low-density lipoprotein (1D1-C) in the serum of normal and endogenous high-cholesterol animals. Studies on various animal models have shown that Policosanol can reduce cholesterol in the liver, adipose tissue, and heart. Non-clinical models have shown that Policosanol exerts its effects by inhibiting the biosynthesis of cholesterol. In addition, Policosanol increases the binding and internalization of 1D1 to receptors, promotes the catabolism of 1D1-C, and thus reduces the level of 1D1-C in plasma. Policosanol can also increase the level of high-density lipoprotein (HD1-C) and reduce the levels of triglycerides and very low-density lipoprotein (V1D1-C). 2. Toxicological studies: Preclinical studies have shown that oral administration of Policosanol has almost no acute toxicity. The 1D50 of rats, mice, and rabbits is higher than 5000 mg/kg. The tolerance study of multiple administration of Macaca arctoides monkeys showed that the highest dose (500 mg/kg) did not cause any changes in clinical, hematological and blood biochemical indicators. 3. Genotoxicity: The results of the Ames test, mouse micronucleus test and dominant lethality test of policosanol were all negative. 4. Reproductive toxicity: No teratogenic effect was found in rats and rabbits at a dose of 1000 mg/kg of policosanol. Two-generation fertility and reproductive toxicity studies did not show any effect of policosanol on fertility and fetal development. 5. Carcinogenicity: In the carcinogenicity test of rats (50-500 mg/kg) and mice, no increase in the incidence of tumors was found after continuous administration for 24 months and 18 months. Similarly, Macaca arctoides monkeys were orally administered (0.25, 2.5 and 25 mg/kg) for 54 weeks, and no biochemical and tissue physiological changes related to drug toxicity were found. Similar results were obtained when Beagle dogs were given 30 or 180 mg of policosanol daily.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Policosanol Tablets
Ingredients	The main component of this product is polyunsaturated alcohol, and its main component is 1-octacosanol. Other components include: 1-dotriacontanol, 1-triacontanol, 1-tetracosanol, 1-tetratriacontanol, 1-hexacosanol, 1-heptacosanol and 1-nonacosanol.
Indication	1. Laboratory tests have been conducted on policosanol and the following drugs: Anticoagulants: Studies on the drug interaction between policosanol and heparin have shown that single or multiple doses of policosanol given orally to rats have no significant effect on fibrinolysis and bleeding time. 2. Antipyrine and theophylline: Oral administration of policosanol to Beagle dogs has no significant effect on the pharmacokinetics of antipyrine and theophylline. This shows that policosanol does not affect the metabolism of drugs through the liver microsomal enzyme system. 3. Nifedipine: In animal models, multiple administrations of policosanol have no effect on the anti-ischemic and antihypertensive effects of nifedipine, and there is no pharmacological interaction between nifedipine and the drug. 4. Propranolol: Multiple administrations of policosanol have no effect on the negative heart rate effect of propranolol. Not only that, in animal models, appropriate amounts of policosanol
Specifications	10 mg

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