tert-Butyl bromide

137.02

137.02

1730892

208-065-9

5LWO08435U

8418

2342

DTXSID5060144

Colorless liquid

29033036

0

2.54 (est)

Clear colorless to yellow-brown Liquid

1.2125 g/cm³ @ Temp: 25 °C

-16.2 °C

73.3 °C @ Press: 760 Torr

65 °F

1.438

H2O: insoluble

Flammables area

179.9 hPa (25 °C)

Abdominal cavity-rat LD50: 4400 mg/kg; abdominal cavity-mouse LD50: 1250 mg/kg

Inflammable in case of open flame, high temperature, oxidant; decomposition of toxic bromide gas by high heat

Henry's Law constant = 0.041 atm-cu m/mol at 25 °C (est)

At 210 °C /isomerizes/ to isobutyl bromide|Hydroxyl radical reaction rate constant = 4.1X10-13 cu cm/molec-sec at 25 °C (est)

Highly flammable. Insoluble in water.

Halogenated Organic Compounds

Highly Flammable

Halogenated aliphatic compounds, such as BROMOMETHYLPROPANE, are moderately or very reactive. Halogenated organics generally become less reactive as more of their hydrogen atoms are replaced with halogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. Burning generates toxic fumes of bromine.

7.603 kcal/mol at 25 °C

II

3

UN 2342 3/PG 2

3

11-36/37/38

16-33-37/39-26

TX4150000

F,Xi

Treasury is ventilated, low temperature and dry; stored separately from oxidant

Stable under normal temperatures and pressures.

P210

H225

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016)|Flammable - 3rd degree

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: CAUTION: All these products have a very low flash point: Use of water spray when fighting fire may be inefficient. SMALL FIRE: Dry chemical, CO2, water spray or regular foam. LARGE FIRE: Water spray, fog or regular foam. Do not use straight streams. Move containers from fire area if you can do it without risk. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet). FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). All equipment used when handling the product must be grounded. Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. A vapor-suppressing foam may be used to reduce vapors. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. Use clean, non-sparking tools to collect absorbed material. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Water spray may reduce vapor, but may not prevent ignition in closed spaces. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

moderately toxic

LD50 Mouse ip 4400 mg/kg|LD50 Rat ip 1250 mg/kg

t-Butyl bromide's production and subsequent use as a laboratory reagent for organic synthesis(1,2) may result in its release to the environment through various waste streams(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 128(SRC), determined from a measured water solubility of 600 mg/L(2) and a regression derived equation(3), indicates that t-butyl bromide is expected to have high mobility in soils. Volatilization of t-butyl bromide from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.041 atm-cu m/mole(SRC) calculated from a vapor pressure of 135 mm Hg(4) and the water solubility(2). The potential for volatilization of t-butyl bromide from dry soil surfaces exists(SRC) based upon its vapor pressure(4). Biodegradation data were not available(SRC, 2005).|AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 128(SRC), determined from a measured water solubility of 600 mg/L(2) and a regression derived equation(3), indicates that t-butyl bromide is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected to occur rapidly(3) based upon an estimated Henry's Law constant of 0.041 atm-cu m/mole(SRC), calculated from a vapor pressure of 135 mm Hg(4) and the water solubility(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1 hour and 5 days, respectively (SRC). According to a classification scheme(5), an estimated BCF of 16(SRC), from its water solubility(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). t-Butyl bromide is an alkyl halide which is susceptible to hydrolysis; however the rate of this reaction has not been measured for this particular compound. Hydrolysis of t-butyl bromide is likely in water at pH 7, 25 °C, as similar compounds, t-butyl chloride and isopropyl bromide have half-lives of 23 seconds and 2.1 days, respectively(6). Biodegradation data were not available(SRC, 2005).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), t-butyl bromide , which has a vapor pressure of 135 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase t-butyl bromide is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 39 days(SRC), calculated from its rate constant of 4.1X10-13 cu cm/molecule-sec at 25 °C that was derived using a structure estimation method(3).

The rate constant for the vapor-phase reaction of t-butyl bromide with photochemically produced hydroxyl radicals has been estimated as 4.1X10-13 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 39 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). t-Butyl bromide is not expected to undergo direct photolysis in the environment since it does not contain functional groups that absorb light in the environmental UV spectrum(SRC). t-Butyl bromide is an alkyl halide, which is susceptible to hydrolysis; however, the rate of this potential reaction has not been measured for this particular compound(SRC). Hydrolysis of t-butyl bromide is likely in water at pH 7, 25 °C, as similar compounds, t-butyl chloride and isopropyl bromide have half-lives of 23 seconds and 2.1 days, respectively(2).

An estimated BCF of 16 was calculated for t-butyl bromide (SRC), using a measured water solubility of 600 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The Koc of t-butyl bromide is estimated as 128(SRC), using a measured water solubility of 600 mg/L(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that t-butyl bromide is expected to have high mobility in soil(SRC).

The Henry's Law constant for t-butyl bromide is estimated as 0.041 atm-cu m/mole(SRC) derived from its vapor pressure, 135 mm Hg(1), and water solubility, 600 mg/L(2). This Henry's Law constant indicates that t-butyl bromide is expected to volatilize rapidly from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 1 hour(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 5 days(SRC). t-Butyl bromide's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). The potential for volatilization of t-butyl bromide from dry soil surfaces may exist(SRC) based upon its vapor pressure(1).

Occupational exposure to t-butyl bromide may occur through inhalation and dermal contact with this compound at workplaces where t-butyl bromide is produced or used; however, exposure may be limited to research laboratory personnel owing to its application as a lab reagent. (SRC)

Tert-butyl bromide absorbed through skin of mice.

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)

Propane, 2-bromo-2-methyl-: ACTIVE

Fire Hazards -> Flammable - 3rd degree