4-HYDRAZINO-BENZOICACIDETHYLESTERHCL

Step 1 : Ethyl 4-hydrazinylbenzoate. hydrochloride: To a stirred and cooled (-20°C) solution of ethyl 4-aminobenzoate (2 g, 12.181 mmol) in cone. HC1 (22 mL) was added aqueous solution of sodium nitrite (925 mg, 13.40 mmol). This mixture was added very slowly to a precooled (-10 °C) mixture of tin chloride (13.8 g, 60.905 mmol) in cone. HC1 (15 mL) and stirred at the same temperature for 30 min. The precipitate obtained was filtered and washed with diethyl ether (2 x 20 mL) to yield 2.2 g of the title product as off white solid; 1H NMR (300 MHz, DMSO-i) δ 1.29 (t, J = 7.2 Hz, 3H), 4.26 (q, J = 7.5 Hz, 2H), 6.99 (d, = 7.8 Hz, 2H), 7.87 (d, = 8.4 Hz, 2H), 8.95 (br s, 1H), 10.48 (br s, 2H); APCI-MS (m/z) 181 (M+H)At room temperature, N-methylquinoxaline-2 (1H) -one (0.1 mmol), In a 100 mL round bottom flask, 1.24 g (4.62 mmol) of

Molecular Weight:216.66
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:216.0665554
Monoisotopic Mass:216.0665554
Topological Polar Surface Area:64.4
Heavy Atom Count:14
Complexity:165
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes