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Songorine

Songorine structure

CAS No:
509-24-0
Formula:
C22H31NO3
Chemical Name:
Songorine
Synonyms:
12,3,6a-Ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one,1-ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-,(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-;Songorine;7,20-Cycloveatchan-12-one,21-ethyl-1,15-dihydroxy-4-methyl-16-methylene-,(1α,15β)-;(3R,6S,6aR,6bR,9R,11R,11aR,12R,12aR,14R)-1-Ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-12,3,6a-ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one;Songorin;Napellonine;Napellonin;Zongorine;Bullatine G;Xuan-Wu 2;12,3,6a-Ethanylylidene-9,11a-methanoazuleno[2,1-b]azocin-8(9H)-one,1-ethyldodecahydro-6,11-dihydroxy-3-methyl-10-methylene-,[3R-(3α,6β,6aα,6bα,9β,11α,11aβ,12α,12aβ,14R*)]-;1354-90-1;1362-38-5;1368-38-3
Categories:
Natural Products > Alkaloids

Description

Songorine is a diterpenoid alkaloid isolated from the genus Aconitum. Songorine is a GABAA receptor antagonist in rat brain and has anti cancer, antiarrhythmic and anti-inflammatory activities. Songorine has the potential for the treatment of Epithelial ovarian cancer (EOC)[1].

Songorine Basic Attributes

Molecular Weight：

357.491

Exact Mass：

357.49

Characteristics

PSA：

60.77000

XLogP3：

0.71

Density：

1.29

Melting Point：

201-203 °C @ Solvent: Methanol

Boiling Point：

535.8±50.0 °C at 760 mmHg

Flash Point：

277.8±30.1 °C

Refractive Index：

1.630

Toxicity：

LD50 in mice (mg/kg): 1575 orally, 630 s.c., 485 i.p., 142.5 i.v.; in rats (mg/kg): 407.5 i.p. (Bisset)

Specific rotation：

D20 -135.4°

Drug Information

MeSH Entry Terms：

songorine

Computed Properties

Molecular Weight:357.5
XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:357.23039385
Monoisotopic Mass:357.23039385
Topological Polar Surface Area:60.8
Heavy Atom Count:26
Complexity:735
Undefined Atom Stereocenter Count:10
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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Guide of Songorine

Description
Basic Attributes
Characteristics
Drug Information
Computed Properties
Learn More Other Chemicals

Songorine

SDS

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