3-Chlorobenzoic acid

156.57

156.57

208-618-4

02UOJ7064K

8443

DTXSID9024770

CRYSTALS|PRISMS FROM WATER

2916399090

37.3

2.7

Crystals or fluffy white powder. (NTP, 1992)

1.496 g/cm³ @ Temp: 25 °C

158 °C

281.3°C at 760 mmHg

123.9±19.8 °C

1.583

<0.1 g/100 mL at 19.5 ºC

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

8.475X10-5 mm Hg at 25 deg C (est).

PKA 3.82

Insoluble in water.

Acids, Carboxylic

M-CHLOROBENZOIC ACID is incompatible with strong oxidizing agents. (NTP, 1992)

NONH for all modes of transport

3

R36/37/38

S26-S36-S37/39

DG4975990

Xi:Irritant

Skin, eye and respiratory irritant.

P261-P305 + P351 + P338

H315-H319-H335

Flash point data for this compound are not available; however, it is probably combustible. (NTP, 1992)

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 70 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and keep it away from oxidizing materials. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

SKIN IRRITANT. /FROM TABLE/

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Chlorobenzoic acid is produced, as an intermediate or final product, by process units covered under this subpart. /Chlorobenzoic acid/

m-Chlorobenzoic acid was qualitatively detected in 1 of 46 U.S. industrial effluent samples(1). It was detected in chlorinated municipal sewage effluent at a concn of 0.6 ppb(2).

LD50 Rabbit oral > 500 mg/kg

m-Chlorobenzoic acid is an anthropogenic compound and it is not known to occur in nature. (SRC)

m-Chlorobenzoic acid is used as a dye intermediate(1) and may be released to the environment as a fugitive emission during its production, formulation an use(SRC). It may also enter the environment in industrial effluent(2) or as a result of the chlorination of municipal wastewater(3).

TERRESTRIAL FATE: If released to soil, m-chlorobenzoic acid is expected to biodegrade under both aerobic and anaerobic conditions although there may be a lengthy lag period before this process ensues(1-4). Its estimated Henry's Law constant, 3.88X10-8 atm-cu m/mol(5,SRC), and its estimated vapor pressure, 8.475X10-5 mm Hg at 25 °C(5-7,SRC) indicate that it is not expected to volatilize from either moist or dry soil to the atmosphere(SRC). Estimated soil adsorption coefficients of 152 and 684(6-8,SRC) indicate that m-chlorobenzoic acid will display moderate to high mobility in soil(9). The pKa of m-chlorobenzoic acid, 3.81 at 25 °C(10), indicates that it will be predominately dissociated in moist soil under the typical pH's found in the environment(SRC).|AQUATIC FATE: If released to water, m-chlorobenzoic acid is expected to biodegrade under both aerobic and anaerobic conditions although there may be a lengthy lag period before ths process ensues(1-3). Its estimated Henry's Law constant, 3.88X10-8 atm-cu m/mol(4,SRC), indicate that it is not expected to volatilize from water to the atmosphere(SRC). The half-life for volatilization from a model river 1 m deep, flowing as 1 m/sec with a wind speed of 3 m/sec is 1180 days(5,SRC). Estimated soil adsorption coefficients of 152 and 684(5-7,SRC) indicate that m-chlorobenzoic acid will not adsorb to sediment and suspended organic matter(SRC). The pKa of m-chlorobenzoic acid, 3.81 at 25 °C(8), indicates that it wil be predominately dissociated in water under the typical pH's found in the environment(SRC).|ATMOSPHERIC FATE: If released to the atmosphere, m-chlorobenzoic acid may undergo a gas-phase reaction with photochemically produced hydroxyl radicals. An estimated rate constant of 4.23X10-13 cu cm/molc-sec(1,SRC) translates to a half-life of 38 days(SRC) for this process using an average atmospheric hydroxyl radical concn of 5X10+5 molc/cu cm(1). The water solubility of m-chlorobenzoic acid, 450 mg/L at 25 °C(2), indicates that it may also undergo atmospheric removal by wet deposition processes(SRC).

An estimated rate constant for the gas-phase reaction of m-chlorobenzoic acid with photochemically produced hydroxyl radicals of 4.23X10-13 cu cm/molc-sec(1,SRC) translates to a half-life of 38 days(SRC) using an average atmospheric hydroxyl radical concn of 5X10+5 molc/cu cm(1).

Estimated bioconcentration factors of 20 and 64(1,SRC) obtained from m-chlorobenzoic acid's water solubility, 450 mg/L at 25 °C(2), and octanol/water partition coefficient, 2.68(3), respectively, can be obtained using an appropriate regression equation. These values indicate that it will not bioconcentrate in fish and aquatic organisms(SRC).

Estimated soil adsorption coefficients of 152 and 684(1,SRC) obtained from m-chlorobenzoic acid's water solubility, 450 mg/l at 25 °C(2), and octanol/water partition coefficient, 2.68(3), respectivley can be obtained using an appropriate regression equation. These values indicate that it will display moderate to high mobility in soil(4).

An estimated Henry's Law constant of 3.88X10-8 atm-cu m/mol(1,SRC), indicates that m-chlorobenzoic acid will not volatilize from either water or moist soil(SRC). Based on this value, the estimated half-life for volatilization from a model river 1 m deep, flowing at 1 m/sec and a wind speed of 3 m/sec is 1180 days(2,SRC). An estimated vapor pressure of 8.475X10-5 mm Hg at 25 °C(2,SRC) obtained from its water solubility, 450 mg/L at 15 °C(3) and an estimated Henry's Law constant indicates that m-chlorobenzoic acid is not expected to volatilize from dry soil to the atmosphere(SRC).

DRINKING WATER: m-Chlorobenzoic acid has been qualitatively detected in U.S. drinking water supplies(1).

Occupational exposure to m-chlorobenzoic acid may occur by dermal contact during its production, formulation or use(SRC). The general population may be exposed by ingestion of contaminated drinking water(1,SRC).

YIELDS M-CHLOROBENZOYL-BETA-D-GLUCURONIC ACID IN RABBIT; YIELDS 3-CHLOROCATECHOL IN PSEUDOMONAS; YIELDS 5-CHLORO-1,2-DIHYDRO-1,2-DIHYDROXYBENZOIC ACID IN ALCALIGENES. /FROM TABLE/|YIELDS M-CHLOROHIPPURIC ACID IN RABBIT. /FROM TABLE/|IN PRESENCE OF 500 MG GLUCOSE, BACTERIA FROM SEWAGE TREATMENT PLANT EFFLUENT COMPLETELY DEGRADED 100 MG M-CHLOROBENZOIC ACID/500 ML MEDIUM DURING 7 DAYS. 1ST METAB WAS 3-CHLOROCATECHOL, WHICH WAS CONVERTED INTO 2-HYDROXY-3-CHLOROMUCONIC SEMIALDEHYDE, WHICH WAS IN TURN FURTHER DECOMP.|Plasmid pJP4 permits its host bacterium, strain JMP134, to degrade and utilize as sole sources of carbon and energy 3-chlorobenzoate and 2,4-dichlorophenoxyacetic acid. Mutagenesis of pJ4 by transposons Tn5 and Tn1771 enabled localization of five genes for enzymes involved in these catabolic pathways. Four of the genes, tfdB, tfdC, tfdD, and tfdE, encoded 2,4-dichlorophenol, hydroxylase, dichlorocatechol 1,2-dioxygenase, chloromuconate cycloisomerase, and chlorodienelactone hydrolase, respectively. No function has been assigned to the fifth gene, trans-chlorodiene lactone isomerase, although it may encode a trans-chlorodiene lactone isomerase. Inactivation of genes dichlorocatechol 1,2-dioxygenase, chloromuconate cycloisomerase, and chlorodienelactone hydrolase which encode the transformation of dichlorocatechol to chloromaleylacetic acid, prevented host strain JMP134 from degrading both 3-chlorobenzoate and 2,4-dichlorophenoxyacetic acid, which indicates that the pathways for these two substrates utilize common enzyme for the dissimilation of chlorocatechols. Studies with cloned catabolic genes from pJP4 indicated that whereas all essential steps in the degradation of 2,4-dichlorophenoxyacetic acid are plasmid encoded, the conversion of 3-chlorobenzoate to chlorocatechol is specified by chromosomal genes.

SYMPTOMS: Exposure to this compound may result in eye and skin irritation. ACUTE/CHRONIC HAZARDS: This compound may be harmful by inhalation, ingestion or skin absorption. It is irritating to eyes, skin, mucous membranes and the upper respiratory tract. When heated to decomposition, this compound emits toxic fumes. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

3-chlorobenzoate

Benzoic acid, 3-chloro-: ACTIVE