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Triac

Triac structure

CAS No:
51-24-1
Formula:
C14H9I3O4
Chemical Name:
Triac
Synonyms:
Benzeneacetic acid,4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-;Thyroacetic acid,3,3′,5-triiodo-;Acetic acid,[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]-;4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodobenzeneacetic acid;3,3′,5-Triiodothyroacetic acid;Triac;[(4-Hydroxy-3-iodo-4-phenoxy)-3,5-diiodophenyl]acetic acid;T3A;Triacana;Tiratricol;Nidolin;2-[4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Tiratricol is a thyroid hormone analog with hepatic, has been used to suppress pituitary TSH secretion, with attenuation of extrapituitary thyromimetic effects.

A metabolite of T3 and T4 thyroid hormones; promoted for hyperlipidemia, localized lipodystrophy, and obesity. Tiratricol has been used in trials studying the treatment of Allan-Herndon-Dudley Syndrome.

Triac Basic Attributes

Molecular Weight：

621.93

Exact Mass：

621.93

EC Number：

200-086-1

UNII：

29OQ9EU4R1

NSC Number：

759294

DSSTox ID：

DTXSID2045232

ATC Code：

D - Dermatologicals|H - Systemic hormonal preparations, excl. sex hormones and insulins

HScode：

2918990090

Characteristics

PSA：

66.8

XLogP3：

4.5

Density：

2.5±0.1 g/cm3

Melting Point：

181.5 °C

Boiling Point：

531.6°C at 760 mmHg

Flash Point：

275.3±30.1 °C

Refractive Index：

1.767

Storage Conditions：

-20ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R20/21/22

safety instructions：

Marks：

Xn: Harmful;

Precautionary statement(s)：

P280

Hazard Statements：

H302-H312-H332

GHS Classification：

|Warning|H302 (97.56%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

MeSH Entry Terms：

3,3',5-triiodothyroacetic acid

Triac Use and Manufacturing

Uses

Thyroid hormone analogue thyroid agent

Use Classification：

Human drugs -> Rare disease (orphan)

Computed Properties

Molecular Weight:621.93
XLogP3:4.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:621.7635
Monoisotopic Mass:621.7635
Topological Polar Surface Area:66.8
Heavy Atom Count:21
Complexity:356
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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