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Ambazon

Ambazon structure

CAS No:
539-21-9
Formula:
C8H11N7S
Chemical Name:
Ambazon
Synonyms:
Hydrazinecarbothioamide,2-[4-[2-(aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]-;Guanidine,[(4-oxo-2,5-cyclohexadien-1-ylidene)amino]-,thiosemicarbazone;Hydrazinecarbothioamide,2-[4-[(aminoiminomethyl)hydrazono]-2,5-cyclohexadien-1-ylidene]-;2-[4-[2-(Aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]hydrazinecarbothioamide;p-Benzoquinone amidinohydrazone thiosemicarbazone;Benzoquinone guanylhydrazone thiosemicarbazone;Faringosept;(4-Oxo-2,5-cyclohexadien-1-ylideneamino)guanidine thiosemicarbazone;Ambazone;Iversal;Primal;Ambazon;1,4-Benzoquinone amidinohydrazone thiosemicarbazone;Anginon;DC 0572;Guanothiazon;Inversal;Ivertol;N-Guanidino-N′-thioureido-p-benzoquinonediimide;[(4-[[(Diaminomethylidene)amino]imino]cyclohexa-2,5-dien-1-ylidene)amino]thiourea;2-(4-(2-Carbamimidoylhydrazono)cyclohexa-2,5-dien-1-ylidene)hydrazinecarbothioamide
Categories:
Chemical Reagents > Organic Reagents

Description

Ambazone is a hydrazone.|Ambazone is an antiseptic agent with potential antibacterial and antileukemic activity. Although the exact mechanism of action remains to be fully elucidated, ambazone appears to interfere with the membrane-bound nucleotide system by increasing the intracellular concentration of cAMP in leukemia cells and macrophages, which potentially contributes to this agent's antineoplastic activity. Furthermore, this agent's affinity for various cellular targets, i.e. membranes, nucleic acids and proteins, may contribute to the overall antibacterial effect.

Ambazon Basic Attributes

Molecular Weight：

237.28484

Exact Mass：

237.28

EC Number：

208-713-0

UNII：

BYK4592A3Q

DSSTox ID：

DTXSID3046407

NCI Thesaurus Code：

C72627

ATC Code：

R - Respiratory system

HScode：

2930909090

Characteristics

PSA：

159

XLogP3：

1.42280

Density：

1.57g/cm3

Melting Point：

192-194 °C (decomp)

Boiling Point：

461.9ºC at 760mmHg

Flash Point：

233.2ºC

Refractive Index：

1.761

Toxicity：

Oral-rat LD50: 750 mg/kg; Oral-Mouse LD50:1000 mg/kg

Flammability characteristics：

Flammable; burning produces toxic sulfur oxides and nitrogen oxide fumes

Safety Information

Storage features：

Warehouse ventilated, low temperature and dry

Precautionary statement(s)：

P264, P270, P301+P312, P330, P501

Hazard Statements：

H302

GHS Classification：

|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory.

Toxicity

Toxicity class：

moderately toxic

Drug Information

MeSH Entry Terms：

1,4-benzoquinone guanylhydrazone thiosemicarbazone

Ambazon Use and Manufacturing

A benzoquidine diimine derivative useful as animal growth substance.

Computed Properties

Molecular Weight:237.29
XLogP3:0.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:237.07966455
Monoisotopic Mass:237.07966455
Topological Polar Surface Area:159
Heavy Atom Count:16
Complexity:289
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes