Ambazon
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Ambazon
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CAS No:
539-21-9
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Formula:
C8H11N7S
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Chemical Name:
Ambazon
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Synonyms:
Hydrazinecarbothioamide,2-[4-[2-(aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]-;Guanidine,[(4-oxo-2,5-cyclohexadien-1-ylidene)amino]-,thiosemicarbazone;Hydrazinecarbothioamide,2-[4-[(aminoiminomethyl)hydrazono]-2,5-cyclohexadien-1-ylidene]-;2-[4-[2-(Aminoiminomethyl)hydrazinylidene]-2,5-cyclohexadien-1-ylidene]hydrazinecarbothioamide;p-Benzoquinone amidinohydrazone thiosemicarbazone;Benzoquinone guanylhydrazone thiosemicarbazone;Faringosept;(4-Oxo-2,5-cyclohexadien-1-ylideneamino)guanidine thiosemicarbazone;Ambazone;Iversal;Primal;Ambazon;1,4-Benzoquinone amidinohydrazone thiosemicarbazone;Anginon;DC 0572;Guanothiazon;Inversal;Ivertol;N-Guanidino-N′-thioureido-p-benzoquinonediimide;[(4-[[(Diaminomethylidene)amino]imino]cyclohexa-2,5-dien-1-ylidene)amino]thiourea;2-(4-(2-Carbamimidoylhydrazono)cyclohexa-2,5-dien-1-ylidene)hydrazinecarbothioamide
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CAS No:
Description
Ambazone is a hydrazone.|Ambazone is an antiseptic agent with potential antibacterial and antileukemic activity. Although the exact mechanism of action remains to be fully elucidated, ambazone appears to interfere with the membrane-bound nucleotide system by increasing the intracellular concentration of cAMP in leukemia cells and macrophages, which potentially contributes to this agent's antineoplastic activity. Furthermore, this agent's affinity for various cellular targets, i.e. membranes, nucleic acids and proteins, may contribute to the overall antibacterial effect.
Ambazon Basic Attributes
237.28484
237.28
208-713-0
BYK4592A3Q
DTXSID3046407
C72627
R - Respiratory system
2930909090
Characteristics
159
1.42280
1.57g/cm3
192-194 °C (decomp)
461.9ºC at 760mmHg
233.2ºC
1.761
Oral-rat LD50: 750 mg/kg; Oral-Mouse LD50:1000 mg/kg
Flammable; burning produces toxic sulfur oxides and nitrogen oxide fumes
Safety Information
Warehouse ventilated, low temperature and dry
P264, P270, P301+P312, P330, P501
H302
|Warning|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory.
Computed Properties
Molecular Weight:237.29
XLogP3:0.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:237.07966455
Monoisotopic Mass:237.07966455
Topological Polar Surface Area:159
Heavy Atom Count:16
Complexity:289
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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