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Epinephrine bitartrate

Epinephrine bitartrate structure

CAS No:
51-42-3
Formula:
C13H19NO9
Chemical Name:
Epinephrine bitartrate
Synonyms:
L-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL BITARTRATE;L-ADRENALINE D-HYDROGENTARTRATE;L-ADRENALINE (+)-BITARTRATE SALT;L-ADRENALINE HYDROGEN TARTRATE;L-EPINEPHRINE D-HYDROGENTARTRATE;L-(-)-EPINEPHRINE-(+)-BITARTRATE;(-)-3,4-dihydroxy-alpha-((methylamino)methyl)benzylalcohol(+)-tartrate(1:1;epinephrined-bitartrate
Categories:
Organic Chemistry > Amides

Description

L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

Epinephrine bitartrate is the bitartrate salt form of epinephrine, a direct-acting sympathomimetic amine with bronchodilator and vasoconstricting activity. Epinephrine bitartrate acts on both alpha and beta-adrenergic receptors. By stimulating alpha-adrenergic receptors locally, this agent causes vasoconstriction and reduces vascular blood flow. Administered in the conjunctiva, epinephrine bitartrate induces vasoconstriction and decreases the production of aqueous humor mediated through alpha-adrenergic receptors. This agent relaxes bronchial smooth muscle through its beta-stimulating actions and causes bronchodilation.

solid

α,β-Adrenergic receptor agonist. Has positive chronotropic and inotropic effects on heart muscle. Activates adenylate cyclase to generate cAMP from ATP.

Epinephrine bitartrate Basic Attributes

Molecular Weight：

333.29

Exact Mass：

333.105988

EC Number：

200-097-1

DSSTox ID：

DTXSID3049415

Color/Form：

white

HScode：

29379000

Characteristics

PSA：

187.78000

Appearance：

white solid

Melting Point：

~155 °C (dec.)

Boiling Point：

413.1ºC at 760 mmHg

Flash Point：

207.9ºC

Refractive Index：

-16.5 ° (C=2, H2O)

Water Solubility：

H2O: soluble

Storage Conditions：

2-8°C

Toxicity：

Oral-mouse LD50: 4 mg/kg; intraperitoneal-mouse LD50: 0.78 mg/kg

Flammability characteristics：

Flammable; burning releases toxic nitrogen oxide fumes

Critical Temperature & Pressure：

2-8°C

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 1

wgk germany：

hazard class code：

T+

safety instructions：

26-28-36/37-45

RTECS Number：

DO3500000

Marks：

T+

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stability/Shelf Life：

Stable. Incompatible with bases, oxidizing agents, iron, iron salts, copper, copper alloys.

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

28-36/37/38

RIDADR：

UN 2811 6.1/PG 1

GHS Classification：

|Danger|H300 (98.08%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 52 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

most toxic

Epinephrine bitartrate Use and Manufacturing

vasodilator

Epinephrine bitartrate is an adrenergic agonist, bronchodilator, antiglaucoma agent.

Computed Properties

Molecular Weight:333.29
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:333.10598118
Monoisotopic Mass:333.10598118
Topological Polar Surface Area:188
Heavy Atom Count:23
Complexity:288
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Adding it to the articaine solution can delay the entry of anesthetics into the systemic circulation, maintain the concentration of active tissues, and also obtain a surgical field with minimal bleeding.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Articaine Epinephrine Injection
Ingredients	This product is a compound preparation, and its components are: each 1.7ml tube contains 68mg of articaine hydrochloride and 17μg of epinephrine tartrate (calculated as epinephrine). Excipients: sodium chloride, sodium metabisulfite, hydrochloric acid, sodium hydroxide, water for injection.
Indication	Co-administration is not recommended due to the presence of adrenaline: Sibutramine Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Caution is required when co-administered due to the presence of adrenaline ◆ Volatile halogenated anesthetics Severe ventricular arrhythmias (increased cardiac response). Limit the dose, for example: less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour for adults. ◆ Imipramine-type antidepressants Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Limit the dose, for example: less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour for adults. ◆ Serotonergic-noradrenergic antidepressants (Misipram and Venlafaxine) Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Limit dose, e.g., less than 0.1 mg in 10 minutes or less than 0.3 mg of epinephrine in 1 hour for adults. ◆ Non-selective MAO inhibitors (iproniazid) generally increase the pressor effect of epinephrine moderately. Use only under close clinical supervision ◆ Type "A" selective MAO inhibitors (moclobemide, toloxatone) derived from non-selective MAO inhibitors present a risk of increasing the pressor effect of epinephrine. Use only under close clinical supervision Guanethidine can significantly increase blood pressure (due to decreased sympathetic tone leading to increased reactivity and/or inhibition of epinephrine or norepinephrine entry into sympathetic nerve fibers). If co-administration is unavoidable, use low doses of the sympathomimetic (epinephrine) with caution.
Specifications	1.7 ml: Articaine hydrochloride 68 mg and epinephrine tartrate 17 micrograms (calculated as epinephrine)

Registered Holders

MATRIX PHARMACORP PRIVATE LTD

United States
Active
VIYASH LIFE SCIENCES PRIVATE LIMITED

India
Active
CAMBREX PROFARMACO MILANO SRL

Brazil
Active

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CAS No.: 51-42-3

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