 Home > Encyclopedia > (-)-Epinephrine (+)-bitartrate

(-)-Epinephrine (+)-bitartrate

(-)-Epinephrine (+)-bitartrate structure

CAS No:
51-42-3
Formula:
C9H13NO3.C4H6O6
Chemical Name:
(-)-Epinephrine (+)-bitartrate
Synonyms:
1,2-Benzenediol,4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-,(2R,3R)-2,3-dihydroxybutanedioate (1:1);Benzyl alcohol,3,4-dihydroxy-α-[(methylamino)methyl]-,(-)-,(+)-tartrate (1:1) (salt);1,2-Benzenediol,4-[1-hydroxy-2-(methylamino)ethyl]-,(R)-,[R-(R*,R*)]-2,3-dihydroxybutanedioate (1:1) (salt);Adrenaline,tartrate (1:1);1,2-Benzenediol,4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-,(2R,3R)-2,3-dihydroxybutanedioate (1:1) (salt);Tartaric acid,compd. with adrenaline;l-Adrenaline d-bitartrate;Epinephrine bitartrate;l-Adrenaline tartrate;l-Adrenaline bitartrate;Adrenaline bitartrate;Adrenaline hydrogen tartrate;(-)-Epinephrine bitartrate;Epinephrine d-bitartrate;Epinephrine tartrate;(-)-Adrenaline bitartrate;(-)-Adrenaline tartrate;l-Adrenaline hydrogen tartrate;Adrenalin bitartrate;(-)-Adrenaline acid tartrate;(-)-Adrenaline hydrogen tartrate;(-)-Epinephrine (+)-bitartrate;l-Epinephrine d-bitartrate;Epinephrine hydrogen tartrate;Adrenaline acid tartrate;R-(-)-Epinephrine bitartrate;L-Adrenaline bitartrate;l-Epinephrine bitartrate;Asmatane Mist;Bronitin Mist;Bronkaid Mist Suspension;Asthmahaler Epitrate;Medihaler-Epi;Primatene Mist Suspension;Epitrate;Adrenatab;3506-10-3;5502-52-3;8028-06-6;16536-89-3
Categories:
Organic Chemistry > Amides

Description

L-Epinephrine bitartrate is an α-adrenergic and β-adrenergic receptor agonist. L-Epinephrine is a hormone secreted by the medulla of the adrenal glands.

(-)-Epinephrine (+)-bitartrate Basic Attributes

Molecular Weight：

333.29

Exact Mass：

333.105988

EC Number：

200-097-1

DSSTox ID：

DTXSID3049415

HScode：

29379000

Characteristics

PSA：

187.78000

Appearance：

white solid

Melting Point：

147-154 °C

Boiling Point：

413.1ºC at 760 mmHg

Flash Point：

207.9ºC

Refractive Index：

-16.5 ° (C=2, H2O)

Water Solubility：

H2O: soluble

Storage Conditions：

2-8°C

Toxicity：

Oral-mouse LD50: 4 mg/kg; intraperitoneal-mouse LD50: 0.78 mg/kg

Flammability characteristics：

Flammable; burning releases toxic nitrogen oxide fumes

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 1

wgk germany：

hazard class code：

28-36/37/38

safety instructions：

26-28-36/37-45

RTECS Number：

DO3500000

Marks：

T+

Storage features：

Treasury is ventilated, low temperature and dry; stored separately from food materials

Stability/Shelf Life：

Stable. Incompatible with bases, oxidizing agents, iron, iron salts, copper, copper alloys.

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H300

GHS Classification：

|Danger|H300 (98.08%): Fatal if swallowed [Danger Acute toxicity, oral]|P260, P261, P262, P264, P270, P271, P280, P284, P301+P310, P302+P350, P302+P352, P304+P340, P305+P351+P338, P310, P312, P320, P321, P322, P330, P332+P313, P337+P313, P361, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 52 companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Toxicity

Toxicity class：

most toxic

(-)-Epinephrine (+)-bitartrate Use and Manufacturing

vasodilator

Computed Properties

Molecular Weight:333.29
Hydrogen Bond Donor Count:8
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:333.10598118
Monoisotopic Mass:333.10598118
Topological Polar Surface Area:188
Heavy Atom Count:23
Complexity:288
Undefined Atom Stereocenter Count:3
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

Adding it to the articaine solution can delay the entry of anesthetics into the systemic circulation, maintain the concentration of active tissues, and also obtain a surgical field with minimal bleeding.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Articaine Epinephrine Injection
Ingredients	This product is a compound preparation, and its components are: each 1.7ml tube contains 68mg of articaine hydrochloride and 17μg of epinephrine tartrate (calculated as epinephrine). Excipients: sodium chloride, sodium metabisulfite, hydrochloric acid, sodium hydroxide, water for injection.
Indication	Co-administration is not recommended due to the presence of adrenaline: Sibutramine Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Caution is required when co-administered due to the presence of adrenaline ◆ Volatile halogenated anesthetics Severe ventricular arrhythmias (increased cardiac response). Limit the dose, for example: less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour for adults. ◆ Imipramine-type antidepressants Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Limit the dose, for example: less than 0.1 mg in 10 minutes or less than 0.3 mg of adrenaline in 1 hour for adults. ◆ Serotonergic-noradrenergic antidepressants (Misipram and Venlafaxine) Paroxysmal hypertension may be accompanied by arrhythmias (inhibition of adrenaline or norepinephrine entering the sympathetic nerve fibers). Limit dose, e.g., less than 0.1 mg in 10 minutes or less than 0.3 mg of epinephrine in 1 hour for adults. ◆ Non-selective MAO inhibitors (iproniazid) generally increase the pressor effect of epinephrine moderately. Use only under close clinical supervision ◆ Type "A" selective MAO inhibitors (moclobemide, toloxatone) derived from non-selective MAO inhibitors present a risk of increasing the pressor effect of epinephrine. Use only under close clinical supervision Guanethidine can significantly increase blood pressure (due to decreased sympathetic tone leading to increased reactivity and/or inhibition of epinephrine or norepinephrine entry into sympathetic nerve fibers). If co-administration is unavoidable, use low doses of the sympathomimetic (epinephrine) with caution.
Specifications	1.7 ml: Articaine hydrochloride 68 mg and epinephrine tartrate 17 micrograms (calculated as epinephrine)

Registered Holders

MATRIX PHARMACORP PRIVATE LTD

United States
Active
VIYASH LIFE SCIENCES PRIVATE LIMITED

India
Active
CAMBREX PROFARMACO MILANO SRL

Brazil
Active

See More Registered Holders

Recommended Suppliers of (-)-Epinephrine (+)-bitartrate

Hangzhou Go Top Peptide Biotech Co.,Ltd. Contact Supplier

CN
6 YRS

Business licensed Certified factory

Manufactory Supplier of Pharmaceutical Peptide,Cosmetic peptide,Custom peptides,API polypeptide,Amino acids and derivatives

Epinephrine bitartrate 98% White or off-white crystalline powder

CAS No.: 51-42-3

Content: 98%

Inquiry
HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

Epinephrine bitartrate

CAS No.: 51-42-3

Content: 99.00%

Inquiry

Latest News on (-)-Epinephrine (+)-bitartrate

Learn More Other Chemicals

(-)-Norepinephrine (+)-bitartrate

51-40-1
(-)-Epinephrine hydrochloride

55-31-2
4,4′-(1,2-Diazenediyl)bis[N,N,N-trimethylbenzenaminium]

21704-61-0
N-(4-Chloro-2-methylphenyl)formamide Formula

21787-81-5
Basic Blue 8 Formula

2185-87-7
3-tert-butyl-5-chloro-2-hydroxy-N-(2-nitrosophenyl)benzamide Formula

21889-00-9
1-Phenylcyclohexylamine Structure

2201-24-3
6-Hydroxymelatonin Structure

2208-41-5
What is Pyrrocaine

2210-77-7
What is 2-amino-N-(4-ethoxyphenyl)ethanesulfonamide

22103-30-6

Hot Searches: omphalitis; methyl ethyl ketoxime; potassium carbonate formula; oxychem; cineole; hexane sds

Guide of (-)-Epinephrine (+)-bitartrate

Description
Basic Attributes
Characteristics
Safety Information
Toxicity
Use and Manufacturing
Computed Properties
Drug Function and Efficacy
Related Drugs
Registered Holders
Recommended Suppliers
Latest News
Learn More Other Chemicals

(-)-Epinephrine (+)-bitartrate

SDS

Request for Quotation



Feedback & Suggestions

Send Message

Thank you for your feedback. If you require further assistance, please contact us by email at info@echemi.com or call us at +86-532-55729510.