Cetyl palmitate
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Cetyl palmitate
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CAS No:
540-10-3
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Formula:
C32H64O2
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Chemical Name:
Cetyl palmitate
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Synonyms:
Hexadecanoic acid,hexadecyl ester;Palmitic acid,hexadecyl ester;Palmitic acid,cetyl ester;1-Hexadecanol,palmitate;Cetin;Cetyl palmitate;Hexadecyl palmitate;n-Hexadecyl hexadecanoate;Palmityl palmitate;Hexadecyl hexadecanoate;Standamul 1616;Starfol Wax CG;n-Hexadecyl n-hexadecanoate;Precifac;Cutina CP;Stepan 653;Stepantex 653;N-SP;Kessco 653;Palmitic acid palmityl ester;Cutina CPA;Estol 3694;Nikkol N-SP;Precifac ATO;S 653;Radia 7500;Nikkol N-SPV;Cutina CP-PH;Kollicream CP 15;Amleps PC;Monecol PC;Amreps PC;Crodamol CP
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CAS No:
Description
white to almost white crystalline powder
OtherSolid
Palmityl palmitate is a palmitate ester resulting from the formal condensation of palmitic acid with palmityl alcohol. It is used as a thickener and emollient in cosmetics. It has a role as a metabolite. It derives from a hexadecan-1-ol.
Characteristics
26.3
15.2
OtherSolid
0.9±0.1 g/cm3
54 °C
451 °C @ Press: 760 Torr
269.8±11.1 °C
1.455
2-8ºC
Cetyl palmitate Use and Manufacturing
General procedure: A total of 1.0 g of 1-octanol (7.69 mmol) was taken in a 50-mL round-bottomed flask, to it NaBr 0.523 g (0.66 eq.), NaBrO 3 0.383 g (0.33 eq.), and 10 mL of H 2 O [comprises the bromide and bromate in 2:1 molar ratio] were added[6f]. The reaction mixture was stirred vigorously to dissolve the contents completely. To the above reaction mixture, the aqueous H 2 SO 4 solution (0.5 eq.) was added slowly under stirring over a period of 2.5 h at room temperature (prepared by adding 0.21 mL of 98percent H 2 SO 4 to 1 mL of water). The reaction mixture was allowed to stir for up to 24 h. After the completion of reaction, the product was extracted with CH 2 Cl 2 (3 15 mL), the organic layer was dried with Na 2 SO 4 and removal of the solvent obtained octyloctanoate in 98percent yield (0.953 g) as colorless liquid. The product was confirmed by GC–MS as well as by NMR.Cetyl alcohol (CA) and palmitic acid (PA) esterification reactions were performed under N2 atmosphere in a four necked round bot-tom flask (250 ml) equipped with a Teflon coated magnetic stirring bar with a stirring rate of 520 rpm and a Dean Stark apparatus surmounted with a reflux condenser. In a typical experiment, 160 mgof catalyst was added into 25 ml of mesitylene and heated up to reaction temperature of 162 C. An equimolar solution of palmitic acid and cetyl alcohol (6 mmol) in 15 ml of mesitylene at room temperature was added into the reactor. All the reactions were carried out for a reaction time of 6 h. In a preliminary set of experiments (Table 1) it was found that the reaction was not controlled by external diffusion at 520 rpm. Samples taken at regular intervals were analyzed by Agilent 6890 gas chromatography using Ultra 1(25 m × 0.3 mm) capillary column equipped with FID. The injector temperature was 280C and the detector temperature was 320 C.The GC oven temperature was changed from 50C at 12C/min to 300C where it was kept for 35 min. Helium was used as the car-rier gas at a flow rate of 37.3 ml/min The split ratio was 24.9:1. Conversion of cetyl alcohol (CA), yield of cetyl palmitate (CP) and the selectivity to CP were defined as below. Conversion(percent)= (CAin −CAout )CAin×100 Yield(percent)= CPoutCAin×100 Selectivity to CP(percent) = CPout(CAin −CAout )×100
Palmityl Palmitate is a wax ester of palmitic acid used in cosmetic and personal care products. The chemical structure of cetyl palmitate (synthetic spermaceti) is the same as whale spermaceti. It may be used to thicken, produce viscose emulsions, give stability, and add texture to emulsions. It is similar to cetearyl palmitate.
Lubricants and lubricant additives
Cleaning and furnishing care products
100,000 - 500,000 lb
All other chemical product and preparation manufacturing|Hexadecanoic acid, hexadecyl ester: ACTIVE
Fatty Acyls [FA] -> Fatty esters [FA07] -> Wax monoesters [FA0701]|Cosmetics -> Emollient
Computed Properties
Molecular Weight:480.8
XLogP3:15.2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:30
Exact Mass:480.49063128
Monoisotopic Mass:480.49063128
Topological Polar Surface Area:26.3
Heavy Atom Count:34
Complexity:379
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
Drug Function and Efficacy
This product is a broad-spectrum antifungal drug. Its mechanism is to selectively inhibit squalene epoxidase, which is necessary for the synthesis of ergosterol.
Registered Holders
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BASF SE
Active
Denmark
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ROBECO, INC.
Inactive
United States
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Zhongnuo Kailin Pharmaceutical Development (Suzhou) Co., Ltd.
Inactive
China
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