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Cystamine

Cystamine structure

CAS No:
51-85-4
Formula:
C4H12N2S2
Chemical Name:
Cystamine
Synonyms:
Ethanamine,2,2′-dithiobis-;Ethylamine,2,2′-dithiobis-;Ethylamine,β,β′-dithiobis-;2,2′-Dithiobis[ethanamine];Bis(β-aminoethyl) disulfide;Cystamine;Cysteinamine disulfide;Cystineamine;Decarboxycystine;β,β′-Diaminodiethyl disulfide;Mercamine disulfide;β-Mercaptoethylamine disulfide;Merkamine disulfide;Bis(2-aminoethyl) disulfide;2,2′-Dithiobis[ethylamine];2-Aminoethane disulfide;L 1591;1,6-Diamino-3,4-dithiahexane;2,2′-Dithiodiethylamine;2-Aminoethyl disulfide;3,4-Dithiahexane-1,6-diamine;2,2′-Disulfanediyldiethanamine;2-(2-Amino-ethyldisulfanyl)-ethylamine;2-[(2-Aminoethyl)disulfanyl]ethan-1-amine;2-(2-Aminoethyldisulfanyl)ethanamine;2087491-48-1
Categories:
Organic Chemistry > Amides

Description

Cystamine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Cystamine is an organic disulfide obtgained by oxidative dimerisation of cysteamine. It has a role as an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is an organic disulfide and a primary amino compound. It derives from a cysteamine.|A radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage.

Cystamine Basic Attributes

Molecular Weight：

152.28100

Exact Mass：

152.28

EC Number：

200-129-4

UNII：

R110LV8L02

DSSTox ID：

DTXSID60199005

HScode：

2930909090

Characteristics

PSA：

102.64000

XLogP3：

1.68580

Density：

1.1559 g/cm³ @ Temp: 20 °C

Melting Point：

135-136 °C

Boiling Point：

106-108 °C @ Press: 5 Torr

Flash Point：

114ºC

Refractive Index：

1.587

Drug Information

MeSH：

Drugs used to protect against ionizing radiation. They are usually of interest for use in radiation therapy but have been considered for other purposes, e.g. military. (See all compounds classified as Radiation-Protective Agents.)|Chemical agents that react with SH groups. This is a chemically diverse group that is used for a variety of purposes. Among these are enzyme inhibition, enzyme reactivation or protection, and labelling. (See all compounds classified as Sulfhydryl Reagents.)|Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. (See all compounds classified as Enzyme Inhibitors.)

MeSH Entry Terms：

2,2' Dithiobisethanamine

Computed Properties

Molecular Weight:152.3
XLogP3:-1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:152.04419074
Monoisotopic Mass:152.04419074
Topological Polar Surface Area:103
Heavy Atom Count:8
Complexity:37
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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51-85-4 2-(2-aminoethyldisulfanyl)ethanamine

CAS No.: 51-85-4

Grade: Industrial Grade

Content: 95%

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