Famphur

325.34

325.34

200-154-0

02UOP4Z0O0

2783

DTXSID7041966

C83710

CRYSTALS|Colorless crystalline powder

2935009019

115.35000

2.13

Liquid

1.4±0.1 g/cm3

52.5-53.5 °C

394.2±52.0 °C at 760 mmHg

>100 °C

1.553

5000 (est. 20 °C)

APPROX 4°C

3 x 10 -5 Pa (est. 20 °C)

Oral-Rat LD50: 28 mg/kg; Oral-Mouse LD50: 9.5 mg/kg

Combustion produces toxic nitrogen oxide, sulfur oxide and phosphorus oxide gas

182.13 Ų [M+Na]+

Slightly soluble in water.

Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters

Organothiophosphates, such as FAMPHUR, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

II

6.1(a)

2783

3

24/25-36/38-63-43-36/37/38-23/24/25-45-67-40-39/23/24/25-11

22-24/25-45-36/37-23-53-16-7

TF7650000

T,Xn,F

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

STABLE /TECHNICAL/

P261-P281-P305 + P351 + P338

H315-H319-H335-H336-H351-H373

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number P097, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.|Potential candidate for liquid injection incineration with a temperature range of 650 to 1600 °C and residence times of 0.1 to 2 seconds. Also, a potential candidate for rotary kiln incineration with a temperature range of 820-1600 °C and residence times of liquids and gases, seconds; solids, hours. Also, a potential candidate for fluidized bed incineration with a temperature range of 450-980 °C and residence times for liquids and gases, seconds; solids, longer.|Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/|Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/

Famphur is used as a pour-on formulation for the control of cattle grubs and to reduce cattle lice infestation to be used at the rate of 1 ounce per 200 pounds body weight, not to exceed a total dosage of 4 ounces. Famphur is to be applied as soon as possible after heel fly activity ceases. Not to be usd on lactating dairy cows or dry dairy cows within 21 days of freshening calves less than 3 months old, animals stressed from castration over-excitement or dehorning, sick or convalescent animals. Animals may be dehydrated and under stress following shipment. Do not treat Brahman bulls.|Famphur is a cholinesterase inhibitor. Do not use this product in animals with exposure to cholinesterase-inhibiting drugs pesticides or chemicals. Limited for beef cattle and nonlactating dairy cows; feed for 10 days; withdraw from dry dairy cows and heifers 21 days prior to freshening; withdraw 4 days prior to slaughter.

Eisler R; Famphur Hazards to Fish, Wildlife, and Invertebrates: A Synoptic Review. NTIS/PB94-156767; Govt Reports Announcements & Index (GRA&I), Issue 13, (1994). Famphur is administered to livestock by intramuscular or subcutaneous injections through the diet, as a dermal pour-on, or as an oral bolus.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form. (ERG, 2016)

|Danger|H300 (92.68%): Fatal if swallowed [Danger Acute toxicity, oral]|P264, P270, P280, P301+P310, P302+P352, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P405, and P501|Aggregated GHS information provided by 41 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: ELIMINATE all ignition sources (no smoking, flares, sparks or flames in immediate area). Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. (ERG, 2016)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. (ERG, 2016)

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, liquid, NOS/|If material on fire or involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, carbon dioxide or dry chemical. /Organophosphorus pesticides, solid, NOS/

If material not on fire and not involved in fire: Keep sparks, flames, and othersources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Use water spray to knock-down vapors. /Organophosphorus pesticides, liquid, NOS/|Personnel protection: Keep upwind. Wear appropriate chemical protective gloves, boots and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. /Organophosphorus pesticides, liquid, NOS/|If material not on fire and not involved in fire: Keep sparks, flames, and othersources of ignition away. Keep material out of water sources and sewers. /Organophosphorus pesticides, solid, NOS/|Personnel protection: Avoid breathing dusts, and fumes from burning material. Keep upwind. Avoid bodily contact with the material. Wear appropriate chemical protective gloves, boots and goggles. Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. Wear positive pressure self-contained breathing apparatus when fighting fires involving this material. If contact with the material anticipated, wear appropriate protective clothing. /Organophosphorus pesticides, solid, NOS/

/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Health: TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. /Organophosphorus pesticide, liquid, flammable, poisonous; Organophosphorus pesticide, liquid, flammable, toxic; Organophosphorus pesticide, liquid, poisonous, flammable; Organophosphorus pesticide, liquid, toxic, flammable/|/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Fire or Explosion: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Those substances designated with a "P" may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. /Organophosphorus pesticide, liquid, flammable, poisonous; Organophosphorus pesticide, liquid, flammable, toxic; Organophosphorus pesticide, liquid, poisonous, flammable; Organophosphorus pesticide, liquid, toxic, flammable/|/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Public Safety: CALL Emergency Response Telephone Number ... . As an immediate precautionary measure, isolate spill or leak area for at least 50 meters (150 feet) in all directions. Keep unauthorized personnel away. Stay upwind. Keep out of low areas. Ventilate closed spaces before entering. /Organophosphorus pesticide, liquid, flammable, poisonous; Organophosphorus pesticide, liquid, flammable, toxic; Organophosphorus pesticide, liquid, poisonous, flammable; Organophosphorus pesticide, liquid, toxic, flammable/|/GUIDE 131: FLAMMABLE LIQUIDS-TOXIC/ Protective Clothing: Wear positive pressure self-contained breathing apparatus (SCBA). Wear chemical protective clothing that is specifically recommended by the manufacturer. It may provide little or no thermal protection. Structural firefighters' protective clothing provides limited protection in fire situations ONLY; it is not effective in spill situations where direct contact with the substance is possible. /Organophosphorus pesticide, liquid, flammable, poisonous; Organophosphorus pesticide, liquid, flammable, toxic; Organophosphorus pesticide, liquid, poisonous, flammable; Organophosphorus pesticide, liquid, toxic, flammable/|For more DOT Emergency Guidelines (Complete) data for FAMPHUR (16 total), please visit the HSDB record page.

No person may /transport,/ offer or accept a hazardous material for transportation in commerce unless that person is registered in conformance ... and the hazardous material is properly classed, described, packaged, marked, labeled, and in condition for shipment as required or authorized by ... /the hazardous materials regulations (49 CFR 171-177)./|The International Air Transport Association (IATA) Dangerous Goods Regulations are published by the IATA Dangerous Goods Board pursuant to IATA Resolutions 618 and 619 and constitute a manual of industry carrier regulations to be followed by all IATA Member airlines when transporting hazardous materials.|The International Maritime Dangerous Goods Code lays down basic principles for transporting hazardous chemicals. Detailed recommendations for individual substances and a number of recommendations for good practice are included in the classes dealing with such substances. A general index of technical names has also been compiled. This index should always be consulted when attempting to locate the appropriate procedures to be used when shipping any substance or article.

P097; An acute hazardous waste when a discarded commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1,000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802; In the Washington D.C. metropolitan area (202) 426-2675. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b).

P097; As stipulated in 40 CFR 261.33, when famphur, as a commercial chemical product or manufacturing chemical intermediate or an off-specification commercial chemical product or a manufacturing chemical intermediate, becomes a waste, it must be managed according to federal and/or state hazardous waste regulations. Also defined as a hazardous waste is any container or inner liner used to hold this waste or any residue, contaminated soil, water, or other debris resulting from the cleanup of a spill, into water or on dry land, of this waste. Generators of small quantities of this waste may qualify for partial exclusion from hazardous waste regulations (40 CFR 261.5(e)).

most toxic

LD50 Rat albino oral 48 mg/tech/kg|LD50 Mouse albino oral 27 mg/kg|LD50 Rat albino acute percutaneous 2730 mg/kg|LD50 Rat, male, oral, 28 mg/kg|For more Non-Human Toxicity Values (Complete) data for FAMPHUR (8 total), please visit the HSDB record page.

Famphur is a chemical of anthropogenic origin, and it is not believed to be produced in nature. (SRC)

Famphur was produced commercially for use as an insecticide, and in the control of cattle grubs, reindeer grub fly, the reindeer nostril fly, and to reduce lice infestations(1,2). It may have entered the environment as a fugitive emission during its manufacture and formulation, or as a result of its application to control pests(SRC). The EPA lists famphur's status as cancelled(3).

TERRESTRIAL FATE: Based on a calculated log Kow of 2.28 obtain from its water solubility(1,2), a soil adsorption coefficient (Koc) of 419 can be obtained for famphur(2,SRC). This value suggests that famphur will display moderate mobility in soil(3), and may be expected to adsorb to soil(SRC). Hydrolysis in moist soils may occur by analogy to its behavior in water(4), however, it is not expected to be a rapid fate process(SRC).|AQUATIC FATE: Hydrolysis under neutral conditions is expected to occur slowly, as an experimental half-life of 115 days has been obtained(1). Hydrolysis in basic waters is expected to occur at a more rapid rate, with an experimental half-life of 6 and 60 days at pH 11 and pH 10, respectively(1,SRC). A calculated Koc of 419(2,SRC), based on the estimated log Kow, 2.289(3), suggests that famphur would be expected to adsorb to sediment and suspended organic matter(SRC). A calculated bioconcentration factor of 31.8(2,SRC), also based on log Kow(3), suggests that bioconcentration in fish and aquatic organisms is not expected to be a significant fate process(SRC).

An experimental rate constant for the hydrolysis of famphur under neutral conditions at 25 °C has been determined to be 2.5X10-4 1/hr, corresponding to a calculated half life of 115 days(1). The rate constant for hydrolysis under basic conditions at 25 °C has been determined to be 5 l/m hr at pH 11 (1), which corresponds to a half-life of approximately 6, and 60 days at pH 11 and pH 10, respectively(SRC).

Based on a calculated log Kow of 2.28(1), a bioconcentration factor of 31.8 can be obtained for famphur(2,SRC). This value suggests that bioaccumulation in fish and aquatic organisms is not expected to be a significant fate process(SRC).

Based on a calculated log Kow of 2.28 obtain from its water solubility(1,2), a soil adsorption coefficient (Koc) of 419 can be obtained for famphur(2,SRC). This value suggests that famphur will display moderate mobility in soil(3), and may be expected to adsorb to soil(SRC).

IN MILK FROM COWS TREATED WITH 23 MG FAMPHUR/KG, 76% OF THE FAMPHUR WAS FOUND IN THE BUTTERFAT & A MAX LEVEL (0.237 PPM) IN WHOLE MILK WAS FOUND IN THE FIRST MILKING AFTER TREATMENT. RESIDUES WERE NEGLIGIBLE (0.008 PPM) BY THE THIRD DAY.

Occupational exposure to famphur may result by dermal contact during its manufacture and formulation into insecticides, or during its application for the control of pests(1,2,SRC).

Insecticides, Organothiophosphate; Anthelmintics|MEDICATION (VET): INSECTICIDE (GRUBICIDE)|MEDICATION (VET): Bo-Ana is used as an insecticide for control of lice infestations

DO NOT TREAT ANIMALS STRESSED FROM CASTRATION, OVEREXCITEMENT OR DEHORNING; SICK OR CONVALESCENT ANIMALS. DO NOT USE BO-ANA POUR-ON TO TREAT CALVES LESS THAN 3 MO OLD, OR TO TREAT DRY DAIRY COWS WITHIN 21 DAYS OF FRESHENING. DO NOT USE ON LACTATING DAIRY COWS. DO NOT SLAUGHTER WITHIN 35 DAYS AFTER TREATMENT.|DO NOT USE ANY DRUG, PESTICIDE, INSECTICIDE, OR CHEMICAL HAVING CHOLINESTERASE-INHIBITING ACTIVITY EITHER SIMULTANEOUSLY OR WITHIN A FEW DAYS BEFORE OR AFTER TREATMENT WITH BO-ANA. BRAHMAN & BRAHMAN CROSSBREEDS ARE LESS TOLERANT OF CHOLINESTERASE-INHIBITING INSECTICIDES THAN OTHER CATTLE. DO NOT USE ON BRAHMAN BULLS.

Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics. (See all compounds classified as Insecticides.)

Famphur was injected into muscle of reindeer. Residues /famphur and its oxon/ were detectable for 4.5 days in liver, 12 days in kidney, 12 days in shoulder muscle. After 20 days, a residue was found only at site of injection in shoulder muscle.|WHEN SHEEP WERE TREATED IV, FAMPHUR WAS ELIMINATED RAPIDLY, WITH 98% OF THE ADMIN DOSE BEING RECOVERED WITHIN 48 HR & NEARLY ALL OF THE RADIOACTIVITY BEING EXCRETED IN THE URINE. AFTER IM ADMIN, 64% OF ADMIN DOSE WAS RECOVERED IN EXCRETA AFTER 72 HR.|SC FAT FROM COWS TREATED @ 150 MG FAMPHUR/KG BODY WT CONTAINED MAX RESIDUES OF FAMPHUR (ABOUT 10 PPM, AVG) 1 DAY AFTER TREATMENT. LEVELS OF TREATMENT @ 50 MG/KG AND 25 MG/KG YIELDED RESIDUES OF 2.08 & 1.8 PPM, RESPECTIVELY.

FAMPHUR WAS DEGRADED AT VARYING RATES BY MICE, AMERICAN COCKROACH, AND MILKWEED BUGS. ... IN ADDITION TO FAMPHUR, BOTH FAMOXON AND N-DESMETHYL FAMPHUR WERE FOUND. TWO WHITE-FACED WESTERN EWES & ONE HEIFER CALF WERE TREATED WITH TRITIATED FAMPHUR. IN ADDITION TO THE OXYGEN ANALOG, O-DESMETHYL, O,N-BISDESMETHYL, TWO GLUCURONIDES, P-HYDROXYBENZENESULFONIC ACID, AND SEVERAL UNKNOWN METABOLITES WERE OBSERVED. IN RATS, MAJOR METABOLITE WAS DIMETHYLSULFAMOYLPHENYL GLUCURONIDE. O,N-BISDESMETHYL FAMPHUR, METHYLSULFAMOYLPHENYL GLUCURONIDE, AND P-HYDROXYBENZENE SULFONIC ACID WERE ALSO OBSERVED.|FAMPHUR WAS DEGRADED AT GREATLY DIFFERING RATES IN MICE, FEMALE AND MALE COCKROACHES, AND MILKWEED BUGS. N-DEMETHYLATION OCCURRED ONLY IN INSECTS.

SC FAT FROM COWS TREATED WITH FAMPHUR CONTAINED MAX RESIDUES 1 DAY AFTER TREATMENT. HALF-LIFE OF RESIDUES WAS 0.9 DAY.

Organophosphorus derivatives act by combining with and inactivating the enzyme acetylcholinesterase (AChE). ... The inactivation of cholinesterase by cholinesterase inhibitor pesticides allows the accumulation of large amounts of acetylcholine, with resultant widespread effects that may be ... separated into 4 categories: (1) Potentiation of postganglionic parasympathetic activity. ... (2) Persistent depolarization of skeletal muscle ... (3) Initial stimulation following depression of cells of central nervous system ... (4) Variable ganglionic stimulation or blockade ... /Cholinesterase inhibitor pesticides/

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016)

Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim calm and warm. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. (ERG, 2016)

Veterinarians treating grub infestations in cattle with pour-on applications of famphur and other organic phosphorus pesticides in poorly ventilated areas occasionally reported nausea, headaches, and irritation of the throat and facial skin. Blood cholinesterase activities were not reduced in these cases, and alkyl phosphate metabolites were only occasionally found in the urine.

famophos

ONE GALLON OF BO-ANA POUR-ON CONTAINS 1.04 LB OF FAMPHUR.|FAMIX MEDICATED PREMIX, ADMIN IN FEED. /DATA FROM TABLE/|Formulation type Pour-on; Dustable powder

Phosphorothioic acid, O-[4-[(dimethylamino)sulfonyl]phenyl] O,O-dimethyl ester: ACTIVE|PREPN: BERKELHAMMER, US PATENT 3,005,004 (1961 TO AMERICAN CYANAMID).|POUR BO-ANA FAMPHUR ALONG BACKLINE FROM SHOULDERS TO TAILHEAD AT RATE OF 1 OZ/200 LB WT. DO NOT REPEAT TREATMENT. TREATMENT WITHIN 4-6 WK OF GRUB EMERGENCE IS OF LITTLE VALUE AND MAY RESULT IN TOXIC EFFECTS DUE TO KILLING OF MIGRATING LARVAE. TREATMENT IS LESS EFFECTIVE IN WET ANIMALS OR ANIMALS EXPOSED TO RAIN AFTER TREATMENT.

Famphur was analyzed by high-performance liquid chromatography with on-line photolysis (hv), followed by electrochemical detection (EC) using single or dual-electrode approaches for the species generated.|Product analysis by GLC; Residues determined by GLC. Details from Cyanamid Co.|Method 8270A: Soil and Water "Semivolatile Organic Compounds by Gas Chromatography/Mass Spectrometry (GC/MS): Capillary Column Technique" Using a Capillary Gas Chromatograph Mass Spectrometer with an estimated quanitiation limit of 20 ug/L (water).|EMSLC Method 622.1 "Thiophosphate Pesticides" Using Gas Chromatography with Alkali Flame Detection with a method detection limit of 19 ug/L.

A GAS CHROMATOGRAPH EQUIPPED WITH A FLAME PHOTOMETRIC DETECTOR PROVIDED A SENSITIVE METHOD FOR DETECTION OF RESIDUES OF FAMPHUR IN REINDEER & CATTLE TISSUES.

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