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Fluocinolone

Fluocinolone structure

CAS No:
807-38-5
Formula:
C21H26F2O6
Chemical Name:
Fluocinolone
Synonyms:
Pregna-1,4-diene-3,20-dione,6,9-difluoro-11,16,17,21-tetrahydroxy-,(6α,11β,16α)-;Pregna-1,4-diene-3,20-dione,6α,9-difluoro-11β,16α,17,21-tetrahydroxy-;(6α,11β,16α)-6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione;Fluocinolone;16α-Hydroxy-6α,9-difluoroprednisolone;6α-Fluorotriamcinolone
Categories:
Analytical Chemistry > Standard

Description

Fluocinolone is a fluorinated steroid.|Fluocinolone has been used in trials studying the treatment and prevention of Candida Infection, Oral Lichen Planus, Macular Degeneration, and Choroidal Neovascularization.|Fluocinolone is a synthetic glucocorticoid with anti-inflammatory and antipruritic activities. Fluocinolone binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinolone that interacts with and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinolone binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis.

Fluocinolone Basic Attributes

Molecular Weight：

412.4243464

Exact Mass：

412.42

EC Number：

212-362-9

UNII：

CT1IX58L9S

NCI Thesaurus Code：

C29053

Characteristics

PSA：

115

XLogP3：

1.1

Density：

1.45±0.1 g/cm3(Predicted)

Melting Point：

266-268 °C @ Solvent: Ethyl acetate, Methanol

Boiling Point：

589ºC at 760 mmHg

Flash Point：

310ºC

Refractive Index：

1.603

Drug Information

MeSH Entry Terms：

6alpha,9-difluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione

Fluocinolone Use and Manufacturing

Fluocinolone, is a medication, used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin condition. It is also a derivative of Fluocinolone Acetonide (F455800).

Computed Properties

Molecular Weight:412.4
XLogP3:1.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:412.16974487
Monoisotopic Mass:412.16974487
Topological Polar Surface Area:115
Heavy Atom Count:29
Complexity:841
Defined Atom Stereocenter Count:9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Fluocinolone

Shandong Airuike Chemical Co., Ltd. Contact Supplier

CN
3 YRS

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Dihydroxyfluocinolone CAS 807-38-5

CAS No.: 807-38-5

Grade: Pharmaceutical Grade

Content: 99%

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Shaanxi Cuikang Pharmaceutical Technolog Contact Supplier

CN
4 YRS

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Manufactory Supplier of Cosmetics raw materials,Pesticide intermediate,Photoelectric material,pharmaceutical intermediates,Raw materials for food and health products,Polymer materials,Fine Chemicals,Synthetic customization

6-alpha,9-alpha-difluoro-11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-1,4-diene-3,20-dione

CAS No.: 807-38-5

Grade: Industrial Grade

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