Heptaminol hydrochloride
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Heptaminol hydrochloride
structure -
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CAS No:
543-15-7
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Formula:
C8H19NO.ClH
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Chemical Name:
Heptaminol hydrochloride
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Synonyms:
2-Heptanol,6-amino-2-methyl-,hydrochloride (1:1);2-Heptanol,6-amino-2-methyl-,hydrochloride;RP 2831;6-Amino-2-methyl-2-heptanol hydrochloride;Cardiosintol;Cortensor;Heptaminol hydrochloride;Heptamyl hydrochloride;2-Methyl-6-amino-2-heptanol hydrochloride;6-Methyl-2-amino-6-heptanol hydrochloride;Izoktamil;Heptamyl;Heptylon;2831RP;Isoktamil;Eoden;Corasor;Respirin;53572-44-4
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CAS No:
Description
Heptaminol hydrochloride is a vasoconstrictor, used in the treatment of low blood pressure, particularly orthostatic hypotension.in vivo: In the rat, Heptaminol hydrochloride prevents orthostatic hypotension, and increases the noradrenaline plasma concentration. In bovine chromaffin cells maintained in primary cultures, Heptaminol hydrochloride is found to be a competitive inhibitor of noradrenaline uptake.[1]
An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.
Characteristics
46.2
2.77710
WHITE CRYSTALLINE POWDER
0.895g/cm3
150 °C
250.1ºC at 760mmHg
105.1ºC
LD50 intraperitoneal in mouse: 900mg/kg
132.2 Ų [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Safety Information
NONH for all modes of transport
3
36/37/38
22-24/25
MJ3240000
Xi
P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, P501
H302
|Warning|H302 (75%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 4 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Computed Properties
Molecular Weight:181.70
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:181.1233420
Monoisotopic Mass:181.1233420
Topological Polar Surface Area:46.2
Heavy Atom Count:11
Complexity:91.3
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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