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Home > Encyclopedia > Palmitoylethanolamide

Palmitoylethanolamide

Palmitoylethanolamide structure

Palmitoylethanolamide 

structure
  • CAS No:

    544-31-0

  • Formula:

    C18H37NO2

  • Chemical Name:

    Palmitoylethanolamide

  • Synonyms:

    Hexadecanamide,N-(2-hydroxyethyl)-;N-(2-Hydroxyethyl)hexadecanamide;N-(2-Hydroxyethyl)palmitamide;Palmidrol;Palmitoylethanolamide;Palmitic acid monoethanolamide;(Hydroxyethyl)palmitamide;Impulsin;Palmitic monoethanolamide;Loramine P 256;2-Palmitamidoethanol;N-Palmitoylethanolamine;2-(Palmitoylamino)ethanol;N-Hexadecanoylethanolamine;AM 3112;NSC 23320;Mackpeart DR 14V;PEA-um;Palmitic acid ethanolamide;1451152-25-2

  • Categories:

    Cosmetic Ingredient  >  Antistatic

Description

AM 3112 is an active endogenous compound which can used for preventing virus infection of the respiratory tract.


OtherSolid|Solid


Palmitoyl ethanolamide is an N-(long-chain-acyl)ethanolamine that is the ethanolamide of palmitic (hexadecanoic) acid. It has a role as an anti-inflammatory drug, an antihypertensive agent, a neuroprotective agent and an anticonvulsant. It is a N-(long-chain-acyl)ethanolamine, an endocannabinoid and a N-(saturated fatty acyl)ethanolamine. It derives from a hexadecanoic acid.|A cannabinoid receptor-inactive eCB-related molecule used as prophylactic in helping to prevent respiratory viral infection. Palmidrol is available for human use as a supplement (400 mg capsules) and as food for medical purposes In Italy and Spain (300 mg and 600 mg tablets).

Palmitoylethanolamide Basic Attributes

299.492

299.49

208-867-9

6R8T1UDM3V

760371|23320

DTXSID4042254

2924199090

Characteristics

49.33000

5.82

OtherSolid

0.9±0.1 g/cm3

98.5 °C

461.5±28.0 °C at 760 mmHg

232.9±24.0 °C

1.463

0.4431 mg/L @ 25 °C (est)

-20ºC

189.87 Ų [M+H]+ [CCS Type: TIMS, Method: single field calibrated]

Safety Information

NONH for all modes of transport

2

P264, P273, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P362, P391, P501

H315

|Danger|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P273, P280, P302+P352, P305+P351+P338, P310, P321, P332+P313, P362, P391, and P501|Aggregated GHS information provided by 8 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Drug Information

Compounds capable of relieving pain without the loss of CONSCIOUSNESS. (See all compounds classified as Analgesics.)|Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects. (See all compounds classified as Anti-Inflammatory Agents, Non-Steroidal.)|Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. (See all compounds classified as Antiviral Agents.)|Compounds that interact with and stimulate the activity of CANNABINOID RECEPTORS. (See all compounds classified as Cannabinoid Receptor Agonists.)

Impulsin

Palmitoylethanolamide Use and Manufacturing

Uses

antiinflammatory


Agricultural chemicals (non-pesticidal)


Agricultural products (non-pesticidal)

All other chemical product and preparation manufacturing|Hexadecanamide, N-(2-hydroxyethyl)-: ACTIVE|Amides, C16-18 and C18-branched, unsatd., N-(hydroxyethyl): INACTIVE

Fatty Acyls [FA] -> Fatty amides [FA08] -> N-acyl ethanolamines (endocannabinoids) [FA0804]|Cosmetics -> Antistatic; Foam boosting; Viscosity controlling

Computed Properties

Molecular Weight:299.5
XLogP3:6.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:16
Exact Mass:299.282429423
Monoisotopic Mass:299.282429423
Topological Polar Surface Area:49.3
Heavy Atom Count:21
Complexity:219
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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