4-Methoxyphenol
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4-Methoxyphenol
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CAS No:
150-76-5
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Formula:
C7H8O2
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Chemical Name:
4-Methoxyphenol
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Synonyms:
Phenol,4-methoxy-;Phenol,p-methoxy-;4-Methoxyphenol;Hydroquinone monomethyl ether;Mequinol;p-Methoxyphenol;4-Hydroxyanisole;p-Hydroxyanisole;1-Hydroxy-4-methoxybenzene;HQMME;Hydroquinone methyl ether;Leucobasal;Leucodine B;Mechinolum;Novo-Dermoquinona;p-Guaiacol;PMF (antioxidant);p-Hydroxymethoxybenzene;MEHQ;p-Hydroxyanisol;BMS 181158;MQ-F;NSC 4960;4-MP;p-Hydroxyphenyl methyl ether;Hydroxyquinone methyl ether;4-Hydroxyphenyl methyl ether;MQ;Methoquinone;HQ-MME;POEA 15
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CAS No:
Description
White crystals. 4-Methoxyphenol is a colorless to white, waxy solid with an odor of caramel and phenol. A combustible solid.Pink crystals or white waxy solid.
Characteristics
29.5
1.3
Clear colorless to pale yellow Liquid
1.55 g/cm3 @ Temp: 20 °C
57 °C
243 °C @ Press: 760 Torr
>230 °F
1.5286 (estimate)
H2O: 40 g/L (25 ºC);soluble in acetone, ethyl acetate, ethanol, ether, benzene and carbon tetrachloride.
Refrigerator
<0.01 mm Hg ( 20 °C)
4.3 (vs air)
Oral-Rat LD50: 1600 mg/kg; Abdominal cavity-mouse LD50: 250 mg/kg
Flammable; spicy and irritating smoke is released from the fire
Odor of caramel and phenol
Safety Information
UN3335 Aviation regulated solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
1
22-36-43
24/25-26-37/39-46
SL7700000
Xn
Storeroom low temperature, ventilated, dry; fireproof; stored separately from strong oxidants
Stable. Combustible. Incompatible with halogens, oxidizing agents.
P201-P273-P280-P308 + P313-P333 + P313-P337 + P313
H302-H317-H319-H361d-H412
4-Methoxyphenol Use and Manufacturing
Using hydroquinone as the raw material, using dimethyl sulfate as the methylating agent, or using methanol as the methylating agent under high temperature and high pressure and catalysis, 4-methoxyphenol can be prepared. Another newer method is to react hydroquinone with methanol in the presence of p-benzoquinone. Mix methanol and concentrated sulfuric acid evenly, add hydroquinone, heat to reflux, dropwise add methanol solution of p-benzoquinone to react for 3h. Cool, neutralize with 40% sodium hydroxide solution, and filter out the sodium sulfate precipitate. The filtrate is recovered from methanol and extracted with ether. The extract is distilled to remove ether, and then distilled under reduced pressure to collect 110-112°C (0.53kPa) fractions to obtain the finished product. The yield was 76%.
Intermediates of Liquid Crystals
Computed Properties
Molecular Weight:124.14
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:124.052429494
Monoisotopic Mass:124.052429494
Topological Polar Surface Area:29.5
Heavy Atom Count:9
Complexity:75
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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