Potassium cyanate

81.12

80.961693

209-676-3

G9C31TWN5M

DTXSID2047692

White, crystalline powder|Colorless crystals|Tetragonal crystals

2837199090

46.8

-0.10202

White Crystalline Powder and Chunks

2.056 g/cm³

315 °C

23.5ºC at 760mmHg

H2O: 750 g/L (20 ºC)

Store below +30°C.

LD50 i.p. in mice: 320 mg/kg (Cerami)

72 g/100 ml water @ 70 °C gives soln of pH above 9.2

Decomposes at 700-900 °C|Decomposes in hot water

Relatively non-corrosive to most irons and natural and synthetic rubbers

NONH for all modes of transport

1

22-36

24/25-26

GS6825000

Xn

Stable. Incompatible with acids.

P305 + P351 + P338

H302-H319

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

When ... Placed in contact with acid or acid fumes, cyanates emit hightly toxic fumes. /Cyanates/

|Warning|H302: Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P280, P301+P312, P305+P351+P338, P330, P337+P313, and P501|Aggregated GHS information provided by 115 companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|P260, P264, P270, P280, P301+P312, P305+P351+P338, P309+P311, P330, P337+P313, P405, and P501

This material is considered to be moderately toxic and personnel should be provided with respiratory and skin protection when handling this compound.|The degree of hazard appears less than with cyanide and some nitriles, but care should be used to avoid inhalation of dust /or/ prolonged and repeated skin contact.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|Do not inhale dust.

Highly irritating to eyes, skin, and mucous membranes. /Cyanic acid/

LD50 Mouse ip 320 mg/kg|LD50 Mouse oral 841 mg/kg

TERRESTRIAL FATE: MATERIAL BREAKS DOWN RAPIDLY IN SOIL TO RESIDUAL NITROGEN & POTASSIUM COMPOUNDS

EXPTL USE: Potassium cyanate reduced the percentage of sickled erythrocytes under low oxygen tension and increased erythrocyte deformability as determined by filterability.|EXPTL USE: Potassium cyanate (0, 0.01-0.1 molar aqueous solution) prevented irreversibly the in vitro sickling of hemoglobin S-containing human erthrocytes during deoxygenation.|EXPTL USE: (VET) Parasite diseases in birds and mammals can be treated with cyanate salts and isocyanates.

Following injection of (14)C-labeled /sodium/ cyanate to mouse, radioactive distribution was 72% broken down to CO2, 7% in urine, 7.5% as specific carbamylation of hemoglobin NH2-terminal valine, 3.3% in bones, 2.1% in muscle, and less than 3% in other organs. /Sodium cyanate/|...This study investigates the fate of potassium cyanide administered orally to rats maintained for up to 4 weeks on either a balanced diet (BD) or a diet lacking the SAAs, L-cystine and L-methionine. In both groups, there was a time-dependent increase in plasma cyanate, with exponential OCN- increases in SAA-deficient rats. A strongly positive linear relationship between blood CN- and plasma OCN- concentrations was observed in these animals.

Not converted to cyanide in toxicologically significant amount. Indeed 72% of injected dose in mice was recovered as evolved CO2 over 24 hr. /cyanates/

The diphosphopyridine nucleotide (DPN)-specific isocitrate dehydrogenase of pig heart is totally and irreversibly inactivated by 0.05 M potassium cyanate at pH 7.4 ...In the presence of manganous ion the addition of isocitrate protects the enzyme against cyanate inactivation. ...The addition of the chelator EDTA essentially prevents protection by isocitrate and manganous ion, ...the substrate alpha-ketoglutarate and the coenzymes DPN and DPNH do not significantly affect the rate of modification of the enzymes by cyanate. Incubation of isocitrate dehydrogenase with 14C-labeled potassium cyanate leads to the incorporation of approximately 1 mol of radioactive cyanate per peptide chain concomitant with inactivation.

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Monitor for seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patent can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... . /Isocyanates, aliphatic thiocyanates, and related compounds/|Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious or has severe pulmonary edema. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias if necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . Consider vasopressors if patient is hypotensive with a normal fluid volume. If signs of hypovolemia are present, administer fluid cautiously. Watch for signs of pulmonary edema ... . Treat seizures with diazepam (Valium) ... . Treat exposure to Lethane 60 Lethane 384, Thanite, methyl, ethyl, or isopropyl thiocyanates; with the cyanide antidote kit (DIRECT PHYSICIAN ORDER ONLY, refer to cyanide guideline and cyanide protocol in Section Four). Use proparacaine hydrochloride to assist eye irrigation ... . /Isocyanates, aliphatic thiocyanates, and related compounds/

/HUMAN EXPOSURE STUDIES/ Two patients developed bilateral subcapsular cataracts while receiving oral sodium cyanate 30-35 mg/kg/day. In one of the patients, lens opacities regressed spontaneously after cyanate therapy was discontinued. /sodium cyanate/|/HUMAN EXPOSURE STUDIES/ Two patients with sickle-cell disease who were receiving sodium cyanate for 440 and 600 days respectively in doses of up to 44 and 41 mg/kg/day had polyneuropathy confirmed by physical exam, quantitative sensory evaluation, nerve conduction test, electromyography and neural biopsy. /Sodium cyanate/|/SIGNS AND SYMPTOMS/ Highly irritating to eyes, skin, and mucous membranes. /Cyanic acid/

KCNO

92% wettable powder|AERO CYANATE|AERO CYANATE WEEDKILLER|ALICYANATE|For more Formulations/Preparations (Complete) data for POTASSIUM CYANATE (15 total), please visit the HSDB record page.

Cyanic acid, potassium salt (1:1): ACTIVE|Its instability in presence of moisture requires that any materials used as extenders or additives must be low in moisture content.|Cyanic acid is used in the formation of some cyanates. /Cyanic acid/|A combination fertilizer and weed killer which kills crabgrass, chick-weed, smartweed and various other plants.

Densitometry proved to be a simple accurate method to quantitatively determine environmental pollutants separated by TLC.|Method: AOAC 952.01, Potassium Cyanate Pesticide formulations; precipitate with semicarbazide hydrochloride and weigh the hydrazodicarbamide produced.[

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