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Suramin sodium

Suramin sodium structure

CAS No:
129-46-4
Formula:
C51H40N6O23S6.6Na
Chemical Name:
Suramin sodium
Synonyms:
1,3,5-Naphthalenetrisulfonic acid,8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-,sodium salt (1:6);1,3,5-Naphthalenetrisulfonic acid,8,8′-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-,hexasodium salt;1,3,5-Naphthalenetrisulfonic acid,8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-,hexasodium salt;Bayer 205;309F;Antrypol;Fourneau 309;Hexasodium sym.-bis(m-aminobenzoyl)-m-amino-p-methylbenzoyl-1-naphthylamino-4,6,8-trisulfonate) carbamide;Moranyl;Naganin;Naganine;Naphuride sodium;Sodium suramin;Suramin sodium;8,8′-[Ureylenebis[m-phenylene carbonylimino(4-methyl-m-phenylene)carbonylimino]]di(1,3,5-naphthalenetrisulfonic acid) hexasodium salt;Suramine sodium;BAY 205;Germanin;Germanin (pharmaceutical);NF 060;CI 1003;Suramin hexasodium;Naphuride;90586-65-5
Categories:
Pharmaceutical Intermediates > Bulk Drug Intermediates

Description

Suramin sodium salt is a polysulfonated naphthylurea with various biological activities. Suramin sodium salt is a DNA topoisomerase II inhibitor with an IC50 of 5 μM.

Suramin sodium is an organic sodium salt that is the hexasodium salt of suramin. It is an FDA approved drug for African sleeping sickness and river blindness. It has a role as an antinematodal drug, a trypanocidal drug, an antineoplastic agent, an angiogenesis inhibitor, an apoptosis inhibitor, an EC 2.7.11.13 (protein kinase C) inhibitor, a GABA antagonist, a GABA-gated chloride channel antagonist, a purinergic receptor P2 antagonist and a ryanodine receptor agonist. It contains a suramin(6-).|Suramin Sodium is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.|A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.

Suramin sodium Basic Attributes

Molecular Weight：

1429.171

Exact Mass：

1427.938599

EC Number：

204-949-3

UNII：

89521262IH

DSSTox ID：

DTXSID30156024

NCI Thesaurus Code：

C1848

ATC Code：

P - Antiparasitic products, insecticides and repellents

Characteristics

PSA：

551.01000

XLogP3：

11.61040

Appearance：

white

Water Solubility：

Ethyl ether Insoluble (mg/mL)

Storage Conditions：

0-6ºC

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R22:Harmful if swallowed. R36/38:Irritating to eyes and skin .

safety instructions：

22-24/25

RTECS Number：

QM7000000

Marks：

Precautionary statement(s)：

P261, P272, P280, P302+P352, P321, P333+P313, P363, P501

Hazard Statements：

H317

GHS Classification：

|Warning|H317 (100%): May cause an allergic skin reaction [Warning Sensitization, Skin]|P261, P272, P280, P302+P352, P321, P333+P313, P363, and P501|Aggregated GHS information provided by 180 companies from 1 notifications to the ECHA C&L Inventory.

Drug Information

MeSH：

Substances used in the treatment or control of nematode infestations. They are used also in veterinary practice. (See all compounds classified as Antinematodal Agents.)|Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA. (See all compounds classified as Trypanocidal Agents.)|Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)

MeSH Entry Terms：

Germanin

Computed Properties

Molecular Weight:1429.2
Hydrogen Bond Donor Count:6
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:10
Exact Mass:1427.9385741
Monoisotopic Mass:1427.9385741
Topological Polar Surface Area:551
Heavy Atom Count:92
Complexity:2940
Covalently-Bonded Unit Count:7
Compound Is Canonicalized:Yes

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Suramin sodium cas129-46-4

CAS No.: 129-46-4

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Content: 99%

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