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Home > Encyclopedia > Tripelennamine hydrochloride

Tripelennamine hydrochloride

pharmaceutical raw materials
Tripelennamine hydrochloride structure

Tripelennamine hydrochloride 

structure
  • CAS No:

    154-69-8

  • Formula:

    C16H21N3.ClH

  • Chemical Name:

    Tripelennamine hydrochloride

  • Synonyms:

    1,2-Ethanediamine,N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-,hydrochloride (1:1);Pyridine,2-[benzyl[2-(dimethylamino)ethyl]amino]-,monohydrochloride;1,2-Ethanediamine,N,N-dimethyl-N′-(phenylmethyl)-N′-2-pyridinyl-,monohydrochloride;2-[Benzyl[2-(dimethylamino)ethyl]amino]pyridine hydrochloride;N-Benzyl-N′,N′-dimethyl-N-2-pyridylethylenediamine hydrochloride;N,N-Dimethyl-N′-(2-pyridyl)-N′-benzylethylenediamine hydrochloride;Pyribenzamine monohydrochloride;Pyrinamine;Stanzamine;Piristin;Tripelennamine monohydrochloride;Dehistin monohydrochloride;Pyribenzamine hydrochloride;Tripelennamine hydrochloride;Dehistin;NIH 10186;ReCovr;Vetobenzamina;Vetibenzamine;PBZ;Azaron

  • Categories:

    Active Pharmaceutical Ingredients  >  Antiallergic Drugs

Description

Tripelennamine Hcl, a H1-receptor antagonist, is a psychoactive drug and member of the pyridine andethylenediamine classes that is used as an antipruritic and first-generation antihistamine.IC50 Value:Target: Histamine H1 receptorTripelennamine can be used in the treatment of asthma, hay fever, rhinitus and urticaria.in vitro: Arterial and mixed venous blood-gas and pH measurements were made at rest before and after saline or drug administration and during incremental exercise leading to


Tripelenamine hydrochloride appears as odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56. (NTP, 1992)


Tripelenamine hydrochloride appears as odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56. (NTP, 1992)|Tripelennamine Hydrochloride is the hydrochloride salt form of tripelennamine, an ethylenediamine derivative with an antihistaminergic property. Tripelennamine hydrochloride competitively blocks central and peripheral histamine H1 receptors, thereby limiting histamine's effects, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contractions of gastrointestinal smooth muscle. In addition, this agent binds to muscarinic receptors, resulting in anticholinergic activity.|A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.

Tripelennamine hydrochloride Basic Attributes

291.82

291.15000

205-833-5

FWV8GJ56ZN

409943

DTXSID6026248

C47774

2933399090

Characteristics

19.4

3.45180

Tripelenamine hydrochloride appears as odorless white crystalline powder or solid. Bitter taste. Solutions are neutral to litmus. pH of aqueous solution (25 mg/mL): 6.71. pH of aqueous solution (50 mg/mL): 6.67. pH of aqueous solution (100 mg/mL): 5.56. (NTP, 1992)

1.20 g/cm3

192-193 °C

387.8°C at 760 mmHg

188.3ºC

greater than or equal to 100 mg/mL at 72° F (NTP, 1992)

Refrigerator

3.21E-06mmHg at 25°C

Water soluble.

Amines, Phosphines, and Pyridines

TRIPELENAMINE HYDROCHLORIDE behaves as a weak organic acid. Materials in this group are generally soluble in water. The resulting solutions contain moderate concentrations of hydrogen ions and have pH's of less than 7.0. They react as acids to neutralize bases. These neutralizations generate heat, but less or far less than is generated by neutralization of inorganic acids, inorganic oxoacids, and carboxylic acid. They usually do not react as either oxidizing agents or reducing agents but such behavior is not impossible.

Safety Information

NONH for all modes of transport

3

22-36/37/38

26-36

US3150000

Xn

P301 + P312 + P330-P305 + P351 + P338

H302-H315-H319-H335

Flash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Drug Information

Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475) (See all compounds classified as Anti-Allergic Agents.)|Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood. (See all compounds classified as Histamine H1 Antagonists.)

SYMPTOMS: Symptoms of exposure to this compound include drowsiness, dryness of the mouth, throat and nose, thickening of bronchial secretions, disturbances of coordination (incoordination), epigastric distress, excitement, ataxia, hallucinations, athetosis, convulsions and post-ictal depression. It may cause agitation. Temporary numbness of the tongue may occur. Irritation may also occur. ACUTE/CHRONIC HAZARDS: This compound may cause irritation. When heated to decomposition it emits very toxic fumes of nitrogen oxides and hydrogen chloride gas. (NTP, 1992)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Azaron

Tripelennamine hydrochloride Use and Manufacturing

Uses

antihistaminic;histamine H1 antagonist

1,2-Ethanediamine, N1,N1-dimethyl-N2-(phenylmethyl)-N2-2-pyridinyl-, hydrochloride (1:?): INACTIVE

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients|Animal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients

Computed Properties

Molecular Weight:291.82
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:291.1502254
Monoisotopic Mass:291.1502254
Topological Polar Surface Area:19.4
Heavy Atom Count:20
Complexity:236
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

This product is an H1 receptor blocker that competitively blocks H1 receptors and produces antihistamine effects. The anti-allergic effect of this product is slightly stronger and more lasting than that of diphenhydramine, and adverse reactions such as drowsiness are less. This product also has a strong antiemetic effect but a weak sedative effect, and has anticholinergic and local anesthetic effects.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Registered Holders

  • China Resources Double-Crane Pharmaceutical Co., Ltd.

    China China
    Active
  • KINGCHEM LABORATORIES INC

    United States United States
    Active
  • SCHUTZ AND CO

    United States United States
    Inactive

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