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Phenelzine sulfate

Phenelzine sulfate structure

CAS No:
156-51-4
Formula:
C8H12N2.H2O4S
Chemical Name:
Phenelzine sulfate
Synonyms:
Hydrazine,(2-phenylethyl)-,sulfate (1:1);Hydrazine,phenethyl-,sulfate (1:1);(β-Phenylethyl)hydrazine sulfate;Nardelzine;Nardil;Phenalzine dihydrogen sulfate;Phenelzine sulfate;(2-Phenylethyl)hydrazine dihydrogen sulfate;(β-Phenylethyl)hydrazine dihydrogen sulfate;Phenelzine dihydrogen sulfate;Phenelzine hydrogen sulfate;Phenethylhydrazine sulfate;Phenelzine bisulfate;Estinerval;Fenelzin;Kalgan;Mao-rem;2-Phenethylhydrazine sulfate;Phenelzine acid sulfate;Stinerval;W 1544A;NSC 170957;75513-79-0
Categories:
Organic Chemistry > Hydrazine or Hydroxylamine Derivatives

Description

Phenelzine sulfate is a non-selective and irreversible monoamine oxidase inhibitor (MAOI), used as an antidepressant and anxiolytic.

Phenelzine sulfate is an organic molecular entity.|Phenelzine Sulfate is a hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects.|One of the MONOAMINE OXIDASE INHIBITORS used to treat DEPRESSION; PHOBIC DISORDERS; and PANIC.

Phenelzine sulfate Basic Attributes

Molecular Weight：

234.27

Exact Mass：

234.06700

EC Number：

205-856-0

UNII：

2681D7P965

NSC Number：

757268|170957

DSSTox ID：

DTXSID3021144

NCI Thesaurus Code：

C47668

HScode：

2928000090

Characteristics

PSA：

121.03000

XLogP3：

2.21160

Melting Point：

166.5-167.5 °C

Boiling Point：

497.4ºC at 760 mmHg

Flash Point：

254.6ºC

Water Solubility：

Freely soluble in water; practically insoluble in ethanol (96%) and in ether .

Safety Information

Packing level：

III

Hazard category：

6.1(b)

Transport codes：

UN 2811 6.1/PG 3

wgk germany：

hazard class code：

RTECS Number：

MV8750000

Marks：

Precautionary statement(s)：

Missing Phrase - N15.00950417

Hazard Statements：

H301

Drug Information

MeSH：

Mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. Several MONOAMINE OXIDASE INHIBITORS are useful as antidepressants apparently as a long-term consequence of their modulation of catecholamine levels. The tricyclic compounds useful as antidepressive agents (ANTIDEPRESSIVE AGENTS, TRICYCLIC) also appear to act through brain catecholamine systems. A third group (ANTIDEPRESSIVE AGENTS, SECOND-GENERATION) is a diverse group of drugs including some that act specifically on serotonergic systems. (See all compounds classified as Antidepressive Agents.)|A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414) (See all compounds classified as Monoamine Oxidase Inhibitors.)

MeSH Entry Terms：

2 Phenethylhydrazine

Phenelzine sulfate Use and Manufacturing

Uses

A hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidepressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.

Use Classification：

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:234.28
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:234.06742811
Monoisotopic Mass:234.06742811
Topological Polar Surface Area:121
Heavy Atom Count:15
Complexity:159
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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