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1,2,4-Trimethoxybenzene

1,2,4-Trimethoxybenzene structure

CAS No:
135-77-3
Formula:
C9H12O3
Chemical Name:
1,2,4-Trimethoxybenzene
Synonyms:
Benzene,1,2,4-trimethoxy-;1,2,4-Trimethoxybenzene;1,2,4-Benzenetriol trimethyl ether;TMB 124;1,3,4-Trimethoxybenzene;1,2,5-Trimethoxybenzene;Hydroxyhydroquinone trimethyl ether;2,4-Dimethoxyanisole
Categories:
Organic Chemistry > Hydrocarbons and Derivatives

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Description

clear light yellow to yellow-brown liquid

1,2,4-Trimethoxybenzene is a member of methoxybenzenes.

1,2,4-Trimethoxybenzene Basic Attributes

Molecular Weight：

168.19

Exact Mass：

168.19

BRN：

2047579

EC Number：

205-219-7

UNII：

3KU3WD07SS

DSSTox ID：

DTXSID5035163

HScode：

29093090

Characteristics

PSA：

27.7

XLogP3：

2.1

Appearance：

clear light yellow to yellow-brown liquid

Density：

1.126 g/mL at 25 °C(lit.)

Melting Point：

19 - 21ºC

Boiling Point：

247 °C

Flash Point：

>230 °F

Refractive Index：

n 20/D 1.533(lit.)

Water Solubility：

Not miscible in water.

Storage Conditions：

Store below +30°C.

Vapor Pressure：

0.0413mmHg at 25°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

safety instructions：

23-24/25

RTECS Number：

DC2770000

Marks：

Hazard note：

Irritant

Stability/Shelf Life：

Stable under normal temperatures and pressures.

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

Drug Information

MeSH Entry Terms：

1,2,4-trimethoxybenzene

1,2,4-Trimethoxybenzene Use and Manufacturing

Methods of Manufacturing

Use vanillin to oxidize with hydrogen peroxide, then hydrolyze, and methylate with dimethyl sulfate; or use hydroquinone to oxidize with sodium dichromate and sulfuric acid to generate hydroquinone, the latter with acetic anhydride Acetylation gives 1, 2, 4-benzenetriol triacetate, which is obtained by methylation with dimethyl sulfate.

Uses

Used as pharmaceutical intermediate

Manufacturing Info：

Benzene, 1,2,4-trimethoxy-: ACTIVE

Computed Properties

Molecular Weight:168.19
XLogP3:2.1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:168.078644241
Monoisotopic Mass:168.078644241
Topological Polar Surface Area:27.7
Heavy Atom Count:12
Complexity:127
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Material

Vanillin

Hydroquinone

Dimethyl sulfate

Hydrogen peroxide

Recommended Suppliers of 1,2,4-Trimethoxybenzene

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
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1,2,4-Trimethoxybenzene

CAS No.: 135-77-3

Content: 99.00%

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