Sodium 2,4,5-trichlorophenolate

219.42800

217.90700

205-239-6

834193HS9A

DTXSID7041336

23.06000

3.79060

2.01 g/mL at 25 °C(lit.)

°Cd ec.)

254.8ºC at 760mmHg

107.9ºC

Solubility: 163 g/100 g acetone @ 25 °C /sodium 2,4,5-trichlorophenolate sesquihydate/|Solubility: 186 g/100 g denatured alc formula 30 @ 25 °C /sodium 2,4,5-trichlorophenolate sesquihydrate/|Solubility: 33 g/100 g ethylene glycol @ 25 °C /sodium 2,4,5-trichlorophenolate sesquihydrate/|Solubility: 241 g/100 g methanol @ 25 °C /sodium 2,4,5-trichlorophenolate sesquihydrate/|Solubility: 113 g/100 g water @ 25 °C /sodium 2,4,5-trichlorophenolate sesquihydrate/

0.0106mmHg at 25°C

EXPLOSION POTENTIAL & THERMAL STABILITY OF REACTION MIXTURE CONTAINING SODIUM 2,4,5-TRICHLOROPHENOLATE WAS STUDIED.

PH OF SATURATED AQ SOLN: 11.0-13.0 /SODIUM 2,4,5-TRICHLOROPHENOLATE SESQUIHYDRATE/

III

6.1(b)

2020

25-41

26-39-45

SN2750000

T

P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, P501

H302

The following wastewater treatment technology has been investigated for 2,4,5-trichlorophenol: Concentration process: Biological treatment. /2,4,5-Trichlorophenol/|Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. /Trichlorophenol/|Group I Containers: Combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) should be disposed of in pesticide incinerators or in specified landfill sites. /Organic or metallo-organic pesticides/|Group II Containers: Non-combustible containers from organic or metallo-organic pesticides (except organic mercury, lead, cadmium, or arsenic compounds) must first be triple-rinsed. Containers that are in good condition may be returned to the manufacturer or formulator of the pesticide product, or to a drum reconditioner for reuse with the same type of pesticide product, if such reuse is legal under Department of Transportation regulations (eg 49 CFR 173.28). Containers that are not to be reused should be punctured ... and transported to a scrap metal facility for recycling, disposal or burial in a designated landfill. /Organic or metallo-organic pesticides/|A potential candidate for rotary kiln incineration at a temperature range of 820 to 1,600 °C and residence times of seconds for liquids and gases, and hours for solids. /2,4,5-Trichlorophenol/

Substances used in the manufacture of paper and paperboard products shall incl: ... sodium trichlorophenate as a slime control agent. (Under the conditions of normal use /sodium trichlorophenate/ would not reasonably be expected to migrate to food, based on available scientific information and data). /Sodium trichlorophenate/

2,4,5-TRICHLOROPHENOL AND ITS SODIUM AND POTASSIUM SALTS: POSITION DOCUMENT 1; REPORT, ISS EPA/SPRD-80/79, ORDER NO PB81-103111: 70 (1979). HEALTH HAZARDS OF 2,4,5-TRICHLOROPHENOL & ITS SODIUM & POTASSIUM SALTS WERE ASSESSED ENVIRONMENTALLY.|USEPA; Ambient Water Quality Criteria Doc: Chlorinated Phenol (1980) EPA 440/5-80-032.|KOZAK VP ET AL; REVIEWS OF THE ENVIRONMENTAL EFFECTS OF POLLUTANTS: XI. CHLOROPHENOLS; USEPA REP EPA-600/1-79-012: 519 PAGES (1979). THIS PAPER DISCUSSES THE HEALTH & ENVIRONMENTAL EFFECTS, PHYSICAL & CHEMICAL PROPERTIES, ANALYTICAL METHODS, BIOLOGICAL ASPECTS (HUMAN & NON-HUMAN), ENVIRONMENTAL DISTRIBUTION & TRANSFORMATION & ENVIRONMENTAL INTERACTIONS OF CHLOROPHENOLS & THEIR CONSEQUENCES.

|Danger|H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P311, P312, P321, P322, P330, P361, P363, P403+P233, P405, and P501|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.

/Wear/ approved dust respirator for toxic dusts; goggles; protective clothing to prevent contact with skin. /Trichlorophenol/|Wear boots, protective gloves, and goggles. /Trichlorophenol/

Non-combustible /Trichlorophenol/|Nonflammable /Trichlorophenol/

EXPLOSION POTENTIAL & THERMAL STABILITY OF REACTION MIXTURE CONTAINING SODIUM 2,4,5-TRICHLOROPHENOLATE WAS STUDIED.

Land Spill: Dig a pit, pond, lagoon, or holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Cover solids with plastic sheet to prevent dissolving in rain or fire fighting water. /Trichlorophenol/|Water Spill: Use natural deep water pockets, excavated lagoons, or sand bag barriers to trap material at bottom. If dissolved, apply activated carbon at ten times the spilled amount in region of 10 ppm or greater concentration. Remove trapped material with suction hoses. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates. /Trichlorophenol/|ACTIVATED CARBON IS A GOOD METHOD FOR REMOVING CHLOROPHENOLS FROM WATER. COMPETITIVE ADSORPTION OCCURS BETWEEN CHLOROPHENOLS & HUMIC SUBSTANCES PRESENT IN NEARLY ALL MUNICIPAL WATER SUPPLIES. THIS COMPETITION DECR THE CAPACITY OF CARBON FOR CHLOROPHENOLS. /CHLOROPHENOLS/

Keep material out of water sources and sewers; Build dikes to contain flow as necessary. Keep upwind; Avoid breathing vapors or dusts; Wash away any material which may have contacted the body with copious amounts of water or soap and water. /Trichlorophenol/|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

... Chlorinated phenols represent important compounds with regard to potential point source and non-point source water contamination. /Chlorinated phenols/|TRICHLOROPHENOL (UNSPECIFIED ISOMERS) HAS BEEN DETECTED IN LANDFILL LEACHATE (AT A LEVEL OF 40 ug/l). /TRICHLOROPHENOL/|TRICHLOROPHENOL (UNSPECIFIED ISOMERS) HAS BEEN DETECTED IN CHLORINATED, BIOLOGICALLY-TREATED EFFLUENT FROM A SEWAGE PLANT. /TRICHLOROPHENOL/

LD50 Rat oral 1620 mg/kg

Chlorophenols may be produced inadvertently by chlorination reactions which take place during the disinfection of wastewater effluents or drinking water sources. Chlorinated phenols represent important compounds with regard to potential point source and non-point source water contamination. /Chlorinated phenol/

... Chlorinated phenols will undergo photolysis in aqueous solutions as a result of ultraviolet irradiation and that photodegradation leads to the substitution of hydroxyl groups in place of the chlorine atoms with subsequent polymer formation. /Chlorinated phenol/|Terrestrial Fate: Contamination of soil in the vicinity of two Finnish sawmills using preservative (Ky-5) against blue-staining fungi that contained chlorophenols was studied. The soil around the treatment basins contained up to 70 mg chlorophenols/kg and that in the storage area for treated lumber up to 6 mg/kg. Contamination extended to a depth of at least 2 m near the treatment basins. Surface water inside the sawmill area contained the same chlorophenols as those used in wood preservation, plus some additional isomers. The ground water and lake water around the sawmill areas were contaminated. The fate of different chlorophenols in soil is probably affected by many factors, such as the water solubility of each chlorophenol, pH of the soil, rainfall, soil organic matter content, type and particle size of the soil, biological and photodegradation and the evaporation of each chlorophenol. /Chlorophenols/

SODIUM 2,4,5-TRICHLOROPHENOLATE YIELDED BY PYROLYSIS DIOXINS, AS WELL AS DIMERS, TRIMERS, TETRAMERS & PENTAMERS. THE ENVIRONMENTAL IMPLICATIONS ARE DISCUSSED.

TRICHLOROPHENOL (UNSPECIFIED ISOMERS) HAS BEEN DETECTED IN RIVERWATER. /TRICHLOROPHENOL/|TRICHLOROPHENOL (UNSPECIFIED ISOMERS) HAS BEEN DETECTED IN TAP-WATER (AT LEVELS OF 2 AND 4 ng/l). /TRICHLOROPHENOL/|TRICHLOROPHENOL (UNSPECIFIED ISOMERS) HAS BEEN DETECTED IN RIVERWATER, LANDFILL LEACHATE (AT A LEVEL OF 40 ug/l), TAP-WATER (AT LEVELS OF 2 AND 4 ng/l), AND IN CHLORINATED, BIOLOGICALLY TREATED EFFLUENT FROM A SEWAGE PLANT. /TRICHLOROPHENOL/

Workers employed in wood treatment plants, tanneries, textile plants, and pulp and paper mills, as well as pesticide spray operators are potentially at risk from exposure to chlorophenols and to impurities in chlorophenol products. /Chlorophenols/

THEY APPEAR NOT TO PENETRATE INTACT RABBIT OR GUINEA PIG SKIN (PERCUTANEOUS ABSORPTION) IN SIGNIFICANT AMOUNTS, IN CONTRAST TO PHENOL & ITS TETRA- & PENTA-CHLORO DERIVATIVES ... . /TRICHLOROPHENOLS/|The compounds are absorbed from the gastroenteric tract and from parenteral sites of injection. /Chlorophenols/

CHLORINATED PHENOLS ... ARE VERY EFFECTIVE (... IN VITRO) AS UNCOUPLERS OF OXIDATIVE PHOSPHORYLATION. THEY THUS PREVENT INCORPORATION OF INORGANIC PHOSPHATE INTO ATP WITHOUT AFFECTING ELECTRON TRANSPORT. AS A RESULT OF THIS ACTION, WHICH IS BELIEVED TO OCCUR @ MITOCHONDRIAL CELL WALL, CELLS CONTINUE TO RESPIRE BUT SOON ARE DEPLETED OF ATP NECESSARY FOR GROWTH. /CHLOROPHENOLS/

THE TRICHLOROPHENOLS ... CAN PRODUCE REDNESS & EDEMA ON SKIN CONTACT ... . IN THE EYE THEY ... SOMETIMES /CAUSED/ CORNEAL INJURY & IRITIS. ... SYSTEMIC EFFECTS ARE NOT DESCRIBED BUT PRESUMABLY RESEMBLE THOSE OF PHENOL POISONING. /TRICHLOROPHENOLS/|SYMPTOMATOLOGY: 1. Burning pain in mouth and throat. White necrotic lesions in mouth, esophagus and stomach. Abdominal pain, vomiting ... and bloody diarrhea. 2. Pallar, sweating weakness, headache, dizziness, tinnitus. 3. Shock: Weak irregular pulse, hypotension, shallow respirations, cyanosis, pallor, and a profound fall in body temperature. 4. Possibly fleeting excitement and confusion, followed by unconsciousness ... . 5. Stentorous breathing, mucous rales, rhonchi, frothing at nose and mouth and other signs of pulmonary edema are sometimes seen. Characteristic odor of phenol on the breath. 6. Scanty, dark-colored ... urine ... moderately severe renal insufficiency may appear. 7. Methemoglobinemia, Heinz body hemolytic anemia and hyperbilirubinemia have been reported ... 8. Death from respiratory, circulatory or cardiac failure. 9. If spilled on skin, pain is followed promptly by numbness. The skin becomes blanched, and a dry opaque eschar forms over the burn. When the eschar sloughs off, a brown stain remains. /Phenol/|Symptoms and pulmonary function were evaluated in 7 subjects exposed to trichlorophenol. Symptoms from upper airways and chest were more common among exposed than in control subjects (60% and 10%). Significantly reduced forced expiratory flow at 75% of vital capacity and incr closing vol were measured, while other spirometric variables and the transfer factor of the lung for carbon monoxide were normal. Incr elastic recoil pressure of the lung and x-ray signs of lung tissue involvement were noticed in 2 subjects. The findings suggest an irritating effect on the lung of trichlorophenol, and it cannot be excluded that long term exposure may produce pulmonary fibrosis. /Trichlorophenol/|... THE SODIUM SALT (DOWICIDE B) IS MORE TOXIC BY MOUTH & MORE IRRITATING ON THE SKIN THAN THE 2 FREE PHENOLS /2,4,5- & 2,4,6-TRICHLOROPHENOL/. ALL ARE LESS TOXIC THAN SIMPLE PHENOL.|Adverse health effects have been seen in workers exposed to chlorophenols contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin or to products synthesized from trichlorophenol. These effects, probably due to 2,3,7,8-tetrachlorodibenzo-p-dioxin, include persistent chloracne, liver dysfunction, neuromuscular weakness, porphyria and psychological changes. /Trichlorophenols/

2,4,5-trichlorophenol

Phenol, 2,4,5-trichloro-, sodium salt (1:1): INACTIVE

Determination in water: Methylene chloride extraction followed by gas chromatography with flame ionization or electron capture detection or gas chromatography plus mass spectrometry. /Trichlorophenols/|TRACE DETERMINATION OF PHENOLIC COMPOUNDS IN WATER BY REVERSED PHASE LIQUID CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION. 1 PPB LEVELS WERE DETECTED. /PHENOLIC COMPOUNDS/|GAS CHROMATOGRAPHIC ANALYSIS OF TRACE PHENOLS BY DIRECT ACETYLATION IN AQUEOUS SOLUTION. /PHENOLS/|CHLOROPHENOLIC POLLUTANTS DETERMINED BY HIGH PRESSURE LIQ CHROMATOGRAPHY. /CHLOROPHENOLIC POLLUTANTS/|PHENOXY HERBICIDES 2,4-D, DICHLORPROP, AND MECOPROP IN MIXT WITH CHLOROPHENOLS WERE SEPARATED BY HIGH-PERFORMANCE LIQ CHROMATOGRAPHY WITH UV DETECTION (280 NM) IN CONJUNCTION WITH ELECTROCHEMICAL DETECTION. /CHLOROPHENOLS/

GAS LIQUID CHROMATOGRAPHY DETERMINATION OF CHLOROPHENOLS IN CHICKEN FLESH. /CHLOROPHENOLS/|A METHOD IS DESCRIBED FOR THE CONFIRMATION OF CHLOROPHENOLS IN HUMAN URINE. HYDROLYZED URINE SAMPLES WERE ANALYZED BY GAS CHROMATOGRAPHY & LIQ CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION & RESULTS COMPARED. IT IS SENSITIVE FOR CHLOROPHENOLS AT LOW PPB RANGE. /CHLOROPHENOLS/|GAS CHROMATOGRAPHIC DETERMINATION OF PHENOLIC COMPOUNDS, INCLUDING 2,6-DICHLOROPHENOL, IN URINE OF INDUSTRIALLY EXPOSED WORKERS. THE DETECTION LIMITS IN URINE RANGE FROM 0.1 MG/L URINE FOR PHENOL TO 1 MG/L FOR THE DI- & TRICHLOROPHENOLS. /PHENOLIC COMPOUNDS/|CHLORINATED PHENOLS IN URINE ARE ISOLATED BY SORPTION ONTO SMALL COLUMN OF MACRORETICULAR RESIN. THE PHENOLS WERE ELUTED FROM COLUMN WITH 2-PROPANOL IN HEXANE; SOLN CONCENTRATED & THE PHENOLS WERE SEPARATED & ANALYZED BY GAS CHROMATOGRAPHY. /CHLORINATED PHENOLS/|For more Clinical Laboratory Methods (Complete) data for SODIUM 2,4,5-TRICHLOROPHENOLATE (6 total), please visit the HSDB record page.