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Tetrahydropyran

Tetrahydropyran structure

CAS No:
142-68-7
Formula:
C5H10O
Chemical Name:
Tetrahydropyran
Synonyms:
2H-Pyran,tetrahydro-;Pyran,tetrahydro-;Tetrahydro-2H-pyran;Oxacyclohexane;Pentamethylene oxide;Tetrahydropyran;Tetrahydropyrane;THP;Oxane;NSC 65448
Categories:
Pharmaceutical Intermediates > Heterocyclic Compound

Description

colorless to light yellow liquidChEBI: A saturated organic heteromonocyclic parent that is cyclohexane in which one of the carbon atoms has been replaced by an oxygen atom.

Oxane is a saturated organic heteromonocyclic parent that is cyclohexane in which one of the carbon atoms has been replaced by an oxygen atom. It is a saturated organic heteromonocyclic parent and a member of oxanes.

Tetrahydropyran Basic Attributes

Molecular Weight：

86.13

Exact Mass：

86.13

BRN：

102436

EC Number：

205-552-8

UNII：

V06I3ILG6B

NSC Number：

65448

DSSTox ID：

DTXSID3059719

Color/Form：

COLORLESS, MOBILE LIQUID

HScode：

29321100

Characteristics

PSA：

9.2

XLogP3：

0.95

Appearance：

Clear colorless Liquid

Density：

0.8814 g/cm³ @ Temp: 20 °C

Melting Point：

-49.2 °C

Boiling Point：

88 °C

Flash Point：

4 °F

Refractive Index：

n20/D 1.42(lit.)

Water Solubility：

H2O: 80 g/L (25 ºC)

Storage Conditions：

Flammables area

Vapor Pressure：

vapor pressure = 71.5 mm Hg @ 25 deg C

Vapor Density：

4.0 (AIR= 1)

Explosive limit：

EXPLOSION HAZARD: MODERATE, BY CHEMICAL REACTION. IT CAN FORM EXPLOSIVE PEROXIDES IF STORED IN UNINHIBITED CONDITION.

Odor：

PUNGENT, SWEETISH ODOR

OH：

1.38e-11 cm3/molecule*sec

Henrys Law Constant：

1.25e-04 atm-m3/mole|Henry's Law constant = 1.25X10-4 atm-cu m/mol @ 25 °C

Experimental Properties：

AZEOTROPE WITH WATER, BP 71 °C, CONTAINS 8.5% WATER; DIPOLE MOMENT: 1.87|hydroxyl radical rate constant = 1.38X10-11 cu m/molc-sec @ 25 °C

Peroxide Forming Chemical：

Tetrahydropyran|D: Other compounds that may form peroxides|Kelly

Safety Information

Packing level：

Hazard category：

Transport codes：

UN 1993 3/PG 2

wgk germany：

hazard class code：

11-36/37/38-9-19-52/53-22

safety instructions：

9-16-26-33-36-61

Marks：

F,Xi,Xn

Stability/Shelf Life：

FORMS PEROXIDES ON EXPOSURE TO AIR

Precautionary statement(s)：

P210-P261-P305 + P351 + P338

Hazard Statements：

H225-H315-H319-H335

GHS Classification：

|Danger|H225 (100%): Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P261, P264, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P370+P378, P403+P233, P403+P235, P405, and P501|Aggregated GHS information provided by 50 companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H225: Highly Flammable liquid and vapor [Danger Flammable liquids]|P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501

Fire Potential：

FIRE HAZARD: DANGEROUS, WHEN EXPOSED TO HEAT, FLAME, OR OXIDIZERS. ...CAN REACT VIGOROUSLY WITH OXIDIZING MATERIALS.

Explosive Limits and Potential：

EXPLOSION HAZARD: MODERATE, BY CHEMICAL REACTION. IT CAN FORM EXPLOSIVE PEROXIDES IF STORED IN UNINHIBITED CONDITION.

Fire Fighting Procedures：

ALCOHOL FOAM.

NFPA Hazard Classification：

| 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.| 3 - Liquids and solids that can be ignited under almost all ambient temperature conditions. Materials produce hazardous atmospheres with air under almost all ambient temperatures or, though unaffected by ambient temperatures, are readily ignited under almost all conditions.| 1 - Materials that in themselves are normally stable but that can become unstable at elevated temperatures and pressures.

Toxicity

Non-Human Toxicity Values：

LDLO RATS ORAL 3000 MG/KG

Tetrahydropyran Use and Manufacturing

Methods of Manufacturing

HYDROGENATION OF 2,3-DIHYDROPYRAN OR ACIDIC DEHYDRATION OF 1,5-PENTANEDIOL|/IT IS/ PREPARED BY HYDROGENATION OF DIHYDROPYRAN (FROM FURFURAL)...CASS, IND ENG CHEM 40, 219 (1948).

Uses

Used as pharmaceutical intermediate

Production

(1972) No Data|(1975) No Data

Manufacturing Info：

2H-Pyran, tetrahydro-: ACTIVE|ALL TECHNICAL TETRAHYDROPYRAN IS STABILIZED AGAINST PEROXIDE FORMATION.

Computed Properties

Molecular Weight:86.13
XLogP3:0.9
Hydrogen Bond Acceptor Count:1
Exact Mass:86.073164938
Monoisotopic Mass:86.073164938
Topological Polar Surface Area:9.2
Heavy Atom Count:6
Complexity:30.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of Tetrahydropyran

NANTONG REFORM PETRO-CHEMICAL CO.,LTD Contact Supplier

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4 YRS

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Tetrahydropyran 142-68-7

CAS No.: 142-68-7

Grade: Industrial Grade

Content: 99%

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Tianjin Shengtai Chemical Co.,Ltd Contact Supplier

CN
3 YRS

Business licensed

Trader Supplier of Epichlorohydrin,Epoxy resin,Calcium chloride,2-Hydroxyethyl acrylate (HEA),2-HYDROXYPROPYLACRYLATE(HPA),2-Hydroxy Ethyl Methacrylate (HEMA),2-Hydroxypropyl methacrylate (HPMA),Acetic acid,PVC,Polyaluminum chloride,Calcium carbide,Pentaerythritol,Sodium benzoate,Sodium bicarbonate,Talcum powder

Tetrahydropyran CAS No. 142-68-7

CAS No.: 142-68-7

Grade: Pharmaceutical Grade

Content: 99.9%

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