Methylacrylamide

(C) Into a 1000 mL four-necked flask equipped with a stirrer, a thermometer, and a gas introduction line, 400 g of Meo-DEAA obtained in the step (b)6.8 g of potassium hydroxide and 0.4 g of TDA were added.Thereafter, a flask was equipped with a distillation column equipped with a packing material, a condenser and a distillation receiver, a trace nitrogen gas was flowed as a carrier, While stirring the reaction solution, the pot temperature was adjusted to 180 ° C. and the degree of vacuum was adjusted to 60 kPa, The pyrolysis reaction was carried out for 12 hours, 307 g (purity = 93percent, yield = 92percent) of crude N, N-diethylacrylamide (DEAA) was obtained from a water condenser.Further, the obtained crude DEAA was transferred to a distillation purification apparatus equipped with a 20 cm McMahon packing (size 6 mm) packed tower and purified by distillation under reduced pressure (60 ° C./0.13 kPa)As a colorless liquid, 258 g of high purity product DEAA (purity 99.8percent) was obtained. Examples 2 to 18 In Example 1, The starting materials, the catalyst, the solvent, the polymerization inhibitor and the reaction conditions of each step were changed as shown in Table 1, and synthesis was carried out in the same manner as in to obtain the respective target compound.The results are shown in Table 2.

Molecular Weight:85.10
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:85.052763847
Monoisotopic Mass:85.052763847
Topological Polar Surface Area:29.1
Heavy Atom Count:6
Complexity:67.9
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes