Spiroxatrine
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Spiroxatrine
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CAS No:
1054-88-2
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Formula:
C22H25N3O3
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Chemical Name:
Spiroxatrine
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Synonyms:
1,3,8-Triazaspiro[4.5]decan-4-one,8-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-;1,3,8-Triazaspiro[4.5]decan-4-one,8-(1,4-benzodioxan-2-ylmethyl)-1-phenyl-;1,4-Benzodioxin,1,3,8-triazaspiro[4.5]decan-4-one deriv.;8-[(2,3-Dihydro-1,4-benzodioxin-2-yl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;8-(1,4-Benzodioxan-2-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;Spiroxatrine;R 5188;132603-40-8
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CAS No:
Description
8-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one is a member of imidazolidines.
Characteristics
54
2.58660
1.32±0.1 g/cm3(Predicted)
215.8-218.0 °C
602.8±55.0 °C(Predicted)
318.4ºC
1.665
H2O: 0.1 M HCl: moderately soluble
1.74E-14mmHg at 25°C
Drug Information
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME. (See all compounds classified as Dopamine Antagonists.)
8-(1,4-benzodioxan-2-ylmethyl)-1-phenyl-1,3,8-triazaspiro(4,5)-decan-4-one
Spiroxatrine Use and Manufacturing
5-HT 1A antagonist. More active and selective than spiperone. Also a very potent α 2C adrenergic receptor antagonist.
Computed Properties
Molecular Weight:379.5
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:379.18959167
Monoisotopic Mass:379.18959167
Topological Polar Surface Area:54
Heavy Atom Count:28
Complexity:557
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
- Hot Searches
- ethoxide
- butan-2-ol
- methanethiol
- ambeed
- hexanol
- ammonium carbonate formula