4,4-Dimethyl-2,6-piperidinedione
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4,4-Dimethyl-2,6-piperidinedione
structure -
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CAS No:
1123-40-6
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Formula:
C7H11NO2
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Chemical Name:
4,4-Dimethyl-2,6-piperidinedione
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Synonyms:
2,6-Piperidinedione,4,4-dimethyl-;Glutarimide,3,3-dimethyl-;4,4-Dimethyl-2,6-piperidinedione;β,β-Dimethylglutarimide;4,4-Dimethylglutarimide;3,3-Dimethylglutarimide;NSC 58194;NSC 99206;1338727-72-2
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CAS No:
4,4-Dimethyl-2,6-piperidinedione Basic Attributes
141.17
141.17
111981
214-373-4
5S2HK9A9UM
99206|58194
DTXSID7074454
29251995
Characteristics
46.2
0.2
1.1522 (rough estimate)
145-146 °C
258.21°C (rough estimate)
125.3ºC
1.5026 (estimate)
Soluble in water.
Safety Information
III
6.1(b)
2811
2
22-36/37/38-43
26-36/37-22
MA4348000
Xn,Xi
P261-P280-P305 + P351 + P338
H302-H315-H317-H319-H335
|Warning|H302 (88.37%): Harmful if swallowed [Warning Acute toxicity, oral]|P261, P264, P270, P271, P272, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P333+P313, P337+P313, P362, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 43 companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
4,4-Dimethyl-2,6-piperidinedione Use and Manufacturing
A suspension of LiAlH4 (5.5 g, 145 mmol) in diethyl ether (300 ML) was treated in portions with PREPARATION F F. 4. 4-Dimethyl-rhoiperidineLithium aluminium hydride (3.36g, 88.55 mmol) was suspended in anhydrous THF (89 ml) and the suspension was cooled to 0 0C. 4, 4-dimethylglutarimide (5g, 35.42 mmol) was partially dissolved in anhydrous THF (89 ml) and this was added dropwise to the suspension of lithium aluminium hydride, maintaining the temperature of the reaction mixture between 0 and 3 0C. The reaction mixture was then heated at 55 0C for 30 minutes. The reaction mixture was then cooled to 0 0C and an aqueous IN sodium hydroxide solution (50 ml) was added dropwise. The reaction mixture was filtered through Celite, washing through with THF and water. The filtrate was evaporated in vacuo to remove most of the THF. The aqueous phase was extracted with diethyl ether. The organic phases were separated off, dried (MgSO^ and evaporated in vacuo to afford the title compound as a yellow oil (2.4 Ig, 60%).
Computed Properties
Molecular Weight:141.17
XLogP3:0.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Exact Mass:141.078978594
Monoisotopic Mass:141.078978594
Topological Polar Surface Area:46.2
Heavy Atom Count:10
Complexity:166
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
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4,4-Dimethyl-2,6-piperidinedione
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