2,2,6,6-tetramethyl-2H-3,5,6-trihydropyran-4-one

5 g of commercial phorone are dissolved in 36 ml of a IM solution of hydrochloric acid and heated at 40°C for 2 days. The reaction mixture is distilled (63-65°C) so as to give 3.0 g of a yellowish oil. Yield = 53percent.Step 1. 2, 2, 6, 64etramethyIdihydro-2H-pyran4(3H)-one: To a stirred solution of 2, 6 diniethyihepta-2.5--dien-4one (100 g, 0.724 mol) was added 6N HC1 (600 mL). then the reaction mixture was heated to 45 °C for 7 days, Upon completion, the reaction was quenched with ice cold water and extracted with ethyl acetate (4 x 1 50 mL). The combined organic extracts were washed with brine, dried over anhydrous Na2SO4, filtered, andconcentrated under reduced pressure to provide a residue. Purification by column chromatography on silica gel (i00200 mesh) using ethyl acetate in hexanc afforded the title compound as a yellow liquid. (yield 28 g, 25percent)Step 1. A reaction vessel was charged with

Molecular Weight:156.22
XLogP3:0.8
Hydrogen Bond Acceptor Count:2
Exact Mass:156.115029749
Monoisotopic Mass:156.115029749
Topological Polar Surface Area:26.3
Heavy Atom Count:11
Complexity:162
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes