Girard's P reagent
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Girard's P reagent
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CAS No:
1126-58-5
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Formula:
C7H10N3O.Cl
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Chemical Name:
Girard's P reagent
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Synonyms:
Pyridinium,1-(2-hydrazinyl-2-oxoethyl)-,chloride (1:1);Pyridinium,1-(carboxymethyl)-,chloride,hydrazide;Pyridinium,1-(2-hydrazino-2-oxoethyl)-,chloride;1-(Carboxymethyl)pyridinium chloride,hydrazide;Girard's P reagent;Girard-P reagent;Pyridinioacetohydrazide chloride;Reagents,Girard's P;1-(2-Hydrazino-2-oxoethyl)pyridinium chloride;1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-iumchloride;1-[(Hydrazinecarbonyl)methyl]pyridin-1-ium chloride
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CAS No:
Safety Information
3
36/38
26-36/37/39
P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, P362
H315
|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P264, P280, P302+P352, P305+P351+P338, P321, P332+P313, P337+P313, and P362|The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
Girard's P reagent Use and Manufacturing
The dry pyridine, ethyl chloroacetate and absolute ethanol were refluxed together for 3h to make a mixture of N-chloro-N-pyridine and absolute ethanol. The reaction was intensely exothermic and the product was immediately precipitated. Filtration and washing with ethanol gave Gerard's reagent P in 90% yield.
Girard’s reagent used in the identification and quantification of protein carbonylation as well as in the modification of nucleosides and nucleotides. Used in the preparation of potent photoactive agents.
Pyridinium, 1-(2-hydrazinyl-2-oxoethyl)-, chloride (1:1): ACTIVE
Computed Properties
Molecular Weight:187.63
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:187.0512396
Monoisotopic Mass:187.0512396
Topological Polar Surface Area:59
Heavy Atom Count:12
Complexity:132
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes
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