Ro-Neet 6E

215.36

215.36

214-482-7

IMZ37NA07H

3082|2992

DTXSID6032356

Colorless liquid|Oily

2930909090

45.6

3.88

Liquid

1.016 g/cm³ @ Temp: 30 °C

11.5 °C

145 °C @ Press: 10 Torr

>100 °C

1.5500 (estimate)

In water, 85 mg/L at 22 deg C

0-6°C

1.57X10-3 mm Hg at 25 deg C

Oral-Rat LD50: 1678 mg/kg; Oral-Mouse LD50: 1275 mg/kg

Combustion produces toxic nitrogen oxide and sulfur oxide gas

Aromatic

3.54e-11 cm3/molecule*sec

Henry's Law constant = 5.25X10-6 atm-cu m/mol at 25 °C (est)

Amber liquid /Technical/|Supercools readily|Hydroxyl radical reaction rate constant = 3.54X10-11 cu cm/molec-sec at 25 °C

Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids or alkalis.

Thiocarbamate Esters and Salts/Dithiocarbamate Esters and Salts

CYCLOATE is a thiocarbamate ester. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.

Noncorrosive

UN30829/PG3

2

22-51/53

61

GU7200000

Xn,N

The warehouse is ventilated, low temperature and dry; stored and transported separately from food materials

Stable to heating to 100 deg C for 16 hr.

P264, P270, P301+P312, P330, P501

H302

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.|Pesticide DIsposal: Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility. /RO-NEET 6-E/|Container Disposal: Triple rinse (or equivalent); then offer for recycling or reconditioning, or puncture and dispose of in a sanitary land fill, or by other procedures approved by State and local authorirites. For bulk and mini-bulk containers, reseal conatiner and offer for reconditioning, or triple rinse (or equivalent) and offer for recycling or reconditioning, or clean in accordance with manufacturer's instructions. Before refilling, inspect thoroughly for damage such as cracks, punctures, bulges, dents, abrasions, and damaged or worn threads on closure devices. Refill only with RO-NEET 6-E; the contents of these containers cannot be completely removed by cleaning. /RO-NEET 6-E/|Do not contaminate water when disposing of equipment wash water or rinsate.|For more Disposal Methods (Complete) data for CYCLOATE (6 total), please visit the HSDB record page.

USEPA/OPPTS; Reregistration Eligibility Decision (RED) for Cycloate (S-ethyl cyclohexyl(ethyl)thiocarbamate) 112 pp. (September 30, 2004) This document provides a thorough review of the scientific data underlying this herbicidee's registration and fulfills the EPA's requirement to determine whether herbicides containing this active ingredient are eligible for reregistration before calling in data on products.

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, be aware of possible short circuiting as this product is transported in a charged state. (ERG, 2016)

|Warning|H302 (95.12%): Harmful if swallowed [Warning Acute toxicity, oral]|P264, P270, P301+P312, P330, and P501|Aggregated GHS information provided by 44 companies from 4 notifications to the ECHA C&L Inventory.

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. Avoid inhalation of asbestos dust. SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area. SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal. LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2016)

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Wear positive pressure self-contained breathing apparatus (SCBA). Structural firefighters' protective clothing will only provide limited protection. (ERG, 2016)|End-Use Products Intended for Occupational Use (Worker Protection Standard). For liquid formulations: Engineering controls are required for all mixers, loaders and applicators. All mixers, loaders, applicators, and other handlers must wear at a minumum: long-sleeved shirt and long pants, shoes plus socks, and chemical-resistant gloves and chemical-resistant apron when mixing and loading.|Handlers /covered under the Worker Protection Standard and performing tasks using liquid formulations/, such as spill clean-up or cleaning equipment, for which engineering controls are not feasible must wear: long-sleeved shirt and long pants, shoes plus socks, chemical-resistant gloves, chemical-resistant apron, and a NIOSH-approved respirator with an organic-vapor removing cartridge with a prefilter approved for pesticides (MSHA/NIOSH approval number prefix TC-23C), or a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or an organic-vapor cartridge or canister with any N2, R or P or He prefilter.|Chemical resistant gloves /include/ barrier laminate or nitrile rubber or neoprene rubber or viton. /Ro-Neet 6-E/|DO ALL LABORATORY SAMPLING, MIXING, WEIGHING, ETC, UNDER ... FUME REMOVAL DEVICE IN AREA HAVING GOOD FORCED VENTILATION OF NONRECIRCULATED AIR, OR WEAR GAS MASK OF PROPER TYPE. ... WEAR CLEAN PROTECTIVE CLOTHING AND NONPERMEABLE GLOVES (SUCH AS POLYETHYLENE GLOVES) AS NECESSARY. /51.041: SPECIAL CHEMICAL HAZARDS/|Chemical-resistant gloves. Long-sleeved shirt and long pants. Shoes plus socks.

Fire point: 149 °C

If material /is/ on fire or involved in /a/ fire do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide. /Carbamate pesticide, liquid, nos, (compounds and preparations) (agricultural insecticides, nec, liquid); Carbamate pesticide, liquid, nos (compounds and preparations) (agricultural insecticides, nec, liquid); Carbamate pesticide, liquid, nos (compounds and preparations) (insecticides, other than agricultural, nec/|Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Solid streams of water may be ineffective. Use foam, dry chemical, or carbon dioxide. /Carbamate pesticide, liquid nos (compounds and preparations) (insecticides, other than agricultural, nec)/|Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use "alcohol" foam, dry chemical or carbon dioxide. /Carbamate pesticide, solid, nos (compounds and preparations) (insecticides, other than agricultural, nec)/|Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Carbamate pesticide, solid, nos (compounds and preparations) (agricultural insecticides, nec, other than liquid)/

Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or other waters unless in accordance with the requirements of a National Pollution Discharge Elimination System (NPDES) permit and the permitting authority has been notified in writing prior to discharge. Do not discharge effluent containing this product to sewer systems without previously notifying the local sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the EPA.

For several good reasons, .... herbicides ... should be handled and applied only with full attention to safety measures that minimize personal contact. Many formulations contain adjuvants (stabilizers, penetrants, surfactants) that may have significant irritating and toxic effects. A number of premixed formulations contain two or more active ingredients; the companion pesticides may be more toxic than the principal herbicide. Good hygienic practice should not be disregarded just because a pesticide is reported to have a high LD50 in laboratory rodents.|Harmful if swallowed. Avoid contact with skin, eyes, and clothing. avoid contamination of feed or food. /RO-NEET 6-E/|/For liquid formulations/ follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry. Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this product's concentrate. Do not reuse them.|SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.|For more Preventive Measures (Complete) data for CYCLOATE (14 total), please visit the HSDB record page.

Irritating to skin and eyes ... .

moderately toxic

LD50 Rat oral 1678 mg/kg|LD50 Rat (male) oral 3250 mg/kg /Ro-Neet 6-E/ /From table/|LD50 Rat (female) oral 4175 mg/kg /Ro-Neet 6-E/ /From table/|LD50 Rat (male) oral 3200 mg/kg /98% ai/ /From table/|For more Non-Human Toxicity Values (Complete) data for CYCLOATE (9 total), please visit the HSDB record page.

/BIRDS and MAMMALS/ The acute oral toxicity to birds is (1) Northern bobwhite (Colinus virginianus), product 98.6% a.i.; LD50 >2150 mg/kg, practically nontoxic (2) Redwing Blackbird; technical product; LD50 >100 mg/kg, no more than moderately toxic and (3) Starling; technical product; LD50 >100 mg/kg, no more than moderately toxic /From table/. Since the LD50 falls in the range of >100 mg/kg to >2150 mg/kg, /EPA considers that/ cycloate is no more than moderately toxic to avian species on an acute oral basis.|/BIRDS and MAMMALS/ Two subacute dietary studies using the technical grade active ingredient (TGAI) were required to establish the toxicity of cycloate to birds. The following information was submitted: (1) Northern bobwhite quail (Colinus virginianus); TGAI 96.8%; 5-day LC50 >5620, practically non-toxic (2)Northern bobwhite quail (Colinus virginianus); TGAI 73.9%; 5 day LC50 >56,000 (8 day; 5 day plus 3 day observation after exposure) practically non-toxic (3) Mallard duck (Anas platyrhynchos); TGAI 98.6%; 5 day LC50 >10,000 (8 day; 5 day exposure followed by 3 day observation period), practically non-toxic (4) Mallard duck (Anas platyrhynchos); TGAI 96.8%; 5 day LC50 >5395, practically non-toxic /From table/|/AQUATIC SPECIES/ LC50 values for freshwater fish falls in the range from 2.6 to 10.5 ppm ai, therefore, cycloate is considered moderately toxic to freshwater fish on an acute basis.|/OTHER TERRESTRIAL SPECIES/ ...The mobility of freshwater snails Physa and Lymnaea was diminished in the presence of ... cycloate (thiocarbamate) ... .|/OTHER TERRESTRIAL SPECIES/ Honey bee (Apis mellifera); 73.9% a.i.; LD50 29.01ug/bee, judged by EPA as practically non-toxic.

Cycloate's production may result in its release to the environment through various waste streams; its use as a herbicide(1) will result in its direct release to the environment(SRC).

TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 345(2) to 800(3) indicate that cycloate is expected to have moderate mobility in soil(SRC). Volatilization of cycloate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 5.2X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 1.57X10-3 mm Hg(4), and water solubility, 85 mg/L(5). Cycloate is not expected to volatilize from dry soil surfaces(SRC) based upon its estimated vapor pressure(4). A field half-life of 30 days has been reported(5). 14C-labeled cycloate was up to 90% mineralized using a continuous flow-through system and soil inoculum(7), indicating that biodegradation is an important environmental fate process in soil(SRC).|TERRESTRIAL FATE: UNDER CROP GROWING CONDITIONS, CYCLOATE HAS HALF-LIFE OF 4-8 WK IN SEVERAL SOILS. IN A LOAM SOIL AT 70-80 °F THE HALF-LIFE WAS 3.5 WK.|AQUATIC FATE: Based on a classification scheme(1), Koc values of 345(2) to 800(3) indicate that cycloate is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is(4) based upon an estimated Henry's Law constant of 5.2X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 1.57X10-3 mm Hg(5), and water solubility, 85 mg/L(6). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 8 days and 64 days, respectively(SRC). According to a classification scheme(7), an estimated BCF of 190(SRC), from its log Kow of 3.88(8) and a regression-derived equation(9), suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC). Cycloate is stable to hydrolysis and photolysis in water(3). 14C-labeled cycloate was up to 90% mineralized using a continuous flow-through system and soil inoculum(10), indicating that biodegradation is an important environmental fate process in water(SRC).|ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cycloate, which has a vapor pressure of 1.57X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cycloate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 10 hrs(SRC), calculated from its rate constant of 3.53X10-11 cu cm/molecule-sec at 25 degC(3). Photodegradation of cycloate was observed in hexane, following exposure to UV light(4). Dipropylamine, ethyl mercaptan, and ethyl disulfide were identified as photolysis products(4). Therefore, cycloate may be susceptible to direct photolysis by sunlight(SRC). A photolysis half-life in air of 5.2 hrs has been reported(5).

The rate constant for the vapor-phase reaction of cycloate with photochemically-produced hydroxyl radicals is 3.54X10-11 cu cm/molecule-sec at 25 °C(1). This corresponds to an atmospheric half-life of about 10 hours at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). Cycloate is stable to hydrolysis and photolysis in water(2). Photodegradation of cycloate was observed in hexane, following exposure to UV light by means of a 400 W medium pressure mercury lamp in a jacketed chamber and maintained at 22 °C(3); dipropylamine, ethyl mercaptan, and ethyl disulfide were identified as photolysis products(3). Therefore cylocate may be susceptible to direct photolysis by sunlight(SRC). A photolysis half-life in air of 5.2 hrs has been reported(2).

An estimated BCF of 190 was calculated for cycloate(SRC), using a log Kow of 3.88(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high, provided the compound is not metabolized by the organism(SRC).

346.74 L/kg|The Koc of cycloate has been experimentally determined to be 345(1,2). The compound tends to sorb to soil under dry conditions and is not reversed if soil is later flooded(3). If already flooded, then cycloate desorbs readily and then volatilizes. Koc values of 500-800 have been reported(3). According to a classification scheme(4), these Koc values suggest that cycloate is expected to have moderate mobility in soil. Cycloate was found at a maximum depth of 6-9 inches in a leaching study using four different soils(5).|Koc 600 and Kd 9 for adsorption, and Koc 767 and Kd 11.5 for desorption in a silt loam with 1.5% organic matter; Koc 500 and Kd 10 for adsorption, and Koc 615 and Kd 12.3 for desorption in a loam with 2% organic matter; Koc 545 and Kd 2.18 for adsorption, and Koc 745 and Kd 2.87 for desorption in a sandy loam with 0.4% organic matter; Koc 678 and Kd 8.13 for adsorption, and Koc 803 and Kd 9.63 for desorption in a clay loam with 1.2% organic matter

The Henry's Law constant for cycloate is estimated as 5.2X10-6 atm-cu m/mole(SRC) derived from its vapor pressure, 1.57X10-3 mm Hg(1), and water solubility, 85 mg/L(2). This Henry's Law constant indicates that cycloate is expected to volatilize from water surfaces(3). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(3) is estimated as 8 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(3) is estimated as 64 days(SRC). Evaporation from water or moist soil of 12.1% after 4 hrs and 13.4% after 5 hrs have been reported(4). Cycloate's estimated Henry's Law constant indicates that volatilization from moist soil surfaces may occur(SRC). Cycloate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(1).

DRINKING WATER: Cycloate was detected in 7 out of 271 wells at concentrations below the maximum contaminant levels although no concentrations were reported(1).|SEAWATER: Cycloate was not detected in lakes sampled in Greece between March and December 1996(1).|RAIN/SNOW/FOG: Cycloate was detected in one of 205 rain events collected in the Axios River Basin of Greece from 8 sampling stations during June 1997 through June 1998; this central Macedonia region in northern Greece is an area of intense agricultural activity(1). The concentration was 0.004 ug/L, detection limit of 0.005 ug/L(1).

Two lactating goats were dosed twice daily (after the morning milking and after the evening milking) via balling gun with gelatin capsules containing uniformly ring-labeled (13)C/(14)C-cycloate for four consecutive days at 23 ppm. This dose rate represents approximately 88x the maximum theoretical dietary exposure for lactating ruminants ... . During the treatment period, milk was collected twice daily. The goats were sacrificed 14-16 hours after the final dosing and samples were stored frozen for up to 5 months prior to residue analysis. The total radioactive residues (TRRs) (expressed as cycloate equivalents) in the tissues of the goat used for residue characterization and identification were: 2.86 ppm in liver, 0.48 ppm in kidney, 0.05 ppm in muscle, and 0.01 ppm in fat. The TRR in milk ranged from 0.10 to 0.13 ppm. ... TRR in muscle and fat were low (< or = 0.05 ppm) ...

Occupational exposure to cycloate may occur through inhalation and dermal contact with this compound at workplaces where cycloate is produced or used. (SRC)

Using (14)C-ring-labeled cycloate /it was/ reported that about 82% of the radioactivity was excreted in rat urine & remainder in feces. No significant amt of radioactivity were found in resp CO2, indicating that the cyclohexyl ring was not broken.|Cycloate is rapidly absorbed by leaves ... . when applied to soil, cycloate is rapidly taken up by the roots of sugarbeets & translocated upward to the stems & leaves. ... no unchanged cycloate could be detected 3 days after treatment showing that it does not persist at all in plants.|After intragastric admin of 1000 mg/kg cycloate in rats, cycloate blood concn were 3.16 ug/mL after 30 min, 10 ug/mL after 1-6 hr, & 1.56 ug/mL after 18 hr. Shows rapid GI tract resorption, & rapid elimination from organism. Highest concn were found in lungs, kidneys, liver, heart & spleen after 1 hr, & in brain after 2 hr. A second maximum was found in spleen & lungs after 3 hr. Cycloate was not found in organs & blood after 24 hr.|... Not absorbed percutaneously.|For more Absorption, Distribution and Excretion (Complete) data for CYCLOATE (13 total), please visit the HSDB record page.

Ethylcyclohexylamine was found as a metabolite /of cycloate/ in rat urine, providing direct evidence for cleavage at the carbonyl carbon and nitrogen bond in the thiocarbamate molecule.|Mouse liver microsome NADPH system showed sulfoxide degradation product of cycloate.|Cycloate is rapidly metabolized in the roots and leaves of sugarbeets to ethyl-cyclohexylamine, carbon dioxide, amino acids, sugars ...|... The urinary metabolites incl cyclohexylamine and dicyclohexylamine...|For more Metabolism/Metabolites (Complete) data for CYCLOATE (15 total), please visit the HSDB record page.

/Rats & mice/ were treated with single oral doses of 10, 40 or 160 mg/kg radiolabeled cycloate. ... Plasma half-life values were approximately 60 hours for the rat and 30 hours for the mouse. ...

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or suffocation. Runoff from fire control may cause pollution. (ERG, 2016)|Teratogens

Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]: Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. (ERG, 2016)

Skin decontamination. Skin contamination should be treated promptly by washing with soap and water. Contamination of the eyes should be treated immediately by prolonged flushing of the eyes with large amounts of clean water. If dermal or ocular irritation persists, medical attention should be obtained without delay. /Other herbicides/|Gastrointestinal decontamination. Ingestions of these herbicides are likely to be followed by vomiting and diarrhea due to their irritant properties. Management depends on: (1) the best estimate of the quantity ingested, (2) time elapsed since ingestion, and (3) the clinical status of the subject. Activated charcoal is probably effective in limiting irritant effects and reducing absorption of most or all of these herbicides. Aluminum hydroxide antacids may be useful in neutralizing the irritant actions of more acidic agents. Sorbitol should be given to induce catharsis if bowel sounds are present and if spontaneous diarrhea has not already commenced. Dehydration and electrolyte disturbances may be severe enough to require oral or intravenous fluids. ... If large amounts of herbicide have been ingested and the patient is seen within an hour of the ingestion, gastrointestinal decontamination should be considered ... . If the amount of ingested herbicides was small, if effective emesis has already occurred, or if treatment is delayed, administer activated charcoal and sorbitol by mouth. /Other herbicides/|Intravenous fluids. If serious dehydration and electrolyte depletion have occurred as a result of vomiting and diarrhea, monitor blood electrolytes and fluid balance and administer intravenous infusions of glucose, normal saline, Ringer's solution, or Ringer's lactate to restore extracellular fluid volume and electrolytes. Follow this with oral nutrients as soon as fluids can be retained. /Other herbicides/|Supportive measures are ordinarily sufficient for successful management of excessive exposures to these herbicides ... . If the patient's condition deteriorates in spite of good supportive care, the operation of an alternative or additional toxicant should be suspected. /Other herbicides/

/GENOTOXICITY/ In a mammalian cell cytogenetics assays (chromosome aberration) ... human lymphocytes, derived from one male and one female healthy donors were exposed in culture to cycloate (98.1% ai ... ), in dimethyl sulfoxide (DMSO) for 3 hours at doses of 0, 10, 50 or 100 ug/mL with and without metabolic activation (both donors). The S-9 homogenate was derived from the livers of Aroclor 1254-induced Alpk:APf Sprague-Dawley rats. Cycloate was cytotoxic, causing a > or = 30% reduction in the mitotic index (MI) at 100 ug/mL without S-9 and an = 15% reduction in the MI at 100 ug/mL with S-9 (both donor cells). In preliminary testing, few, if any metaphases were observed at 150 ug/mL and levels > or = 200 ug/mL were insoluble. The positive controls induced the expected clastogenic responses. There was, however, no indication that cycloate induced an increase in structural chromosome aberrations at any concentration. /98.1%/

cycleate

Sugarbeets account for more than 90% of cycloate usage. EPA estimates that approximately 679,000 pounds of active ingredient (a.i.) are used annually on a total of approximately 288,000 acres. Spinach accounts for almost 7% of cycloate usage with 45,000 pounds of a.i. applied per year on average. Garden beets receive about 17,000 pounds of a.i. annually on just under 8,000 acres treated, nearly 100% crop treated on garden beet acres.

Emulsifiable concentrate|TECHNICAL 95% MIN ...|Mixed formulations: (cycloate +) chloridazon|RO-NEET 6-E SELECTIVE HERBICIDE: Active Ingredient 73.9% Cycloate.|CYCLOATE 6-E: Active Ingredient 73.9% Cycloate.

The WHO Recommended Classification of Pesticides by Hazard identifies Cycloate (technical grade) as Class III: slightly hazardous; Main Use: herbicide.|Cycloate (S-ethyl cyclohexyl(ethyl)thiocarbamate) was first registered in the United States on July 13, 1967, for use as a selective herbicide on sugarbeets and spinach by the Stauffer Chemical Company. The use of cycloate on garden beets was first approved on January 9, 1970. Stauffer Chemical Company transferred the cycloate registrations to ICI Americas, Inc. on December 23, 1987. On January 24, 1994, the registrant name was changed to Zeneca Agrochemicals. Zeneca Agrochemicals merged with Novartis Agribusiness in November 2000 to form Syngenta Crop Protection, Inc. Syngenta Crop Protection, Inc. sold all proprietary rights for cycloate to TRI AG, Inc. on December 1, 2000. Helm Agro US, Inc. is now the agent for TRI AG, Inc.|/IT IS/ APPLIED TO WELL-PREPARED SEED BED INCORPORATED INTO SOIL TO DEPTH OF 2-3 IN JUST BEFORE PLANTING. IT SHOULD BE USED ON MINERAL SOIL ONLY.|CYCLOATE WILL SELECTIVELY CONTROL CERTAIN ANNUAL WEED SPECIES SUCH AS BARNYARDGRASS /CRABGRASS, FOXTAILS, WILD OATS, NIGHTSHADE, HENBIT, LAMBSQUARTERS, PURSLANE, AND PIGWEED/ ... IT IS ONE OF FEW HERBICIDES EFFECTIVE AGAINST NUTSEDGE ... IT ALSO CONTROLS SEEDLING JOHNSONGRASS ... . SUGARBEETS AND SPINACH TOLERATE CYCLOATE WELL ENOUGH FOR COMMERCIAL USAGE.|For more General Manufacturing Information (Complete) data for CYCLOATE (7 total), please visit the HSDB record page.

DETERMINATION OF THIOCARBAMATES IN HERBICIDE FORMULATIONS ANALYSIS IS BY GLC METHOD WITH FID. (APPLICABLE TO LIQUID AND GRANULAR FORMULATIONS OF EPTC, BUTYLATE, MOLINATE, CYCLOATE, VERNOLATE, AND PEBULATE.)|Method: ASTM D5475; Procedure: gas chromatography with a nitrogen-phosphorus detector; Analyte: cycloate; Matrix: ground water and finished drinking water; Detection Limit: 0.25 ug/L.|Method: EPA-NERL 525.2; Procedure: gas chromatography/mass spectrometry; Analyte: cycloate; Matrix: finished drinking water, source water, or drinking water in any treatment stage; Detection Limit: 0.095 ug/L.|Method: EPA-TSC/NERL 507; Procedure: gas chromatography with a nitrogen-phosphorus detector; Analyte: cycloate; Matrix: ground water and finished drinking water; Detection Limit: 0.022 ug/L.|For more Analytic Laboratory Methods (Complete) data for CYCLOATE (8 total), please visit the HSDB record page.

RO-NEET IS EXTRACTED FROM ... URINE WITH DIETHYL ETHER, AND FROM BLOOD WITH SODIUM CITRATE + DIETHYL ETHER. PETROLEUM ETHER IS USED FOR EXTRACTION FROM ORGANS. TLC , UV-SPECTROPHOTOMETRIC, & COLORIMETRIC METHODS ARE DESCRIBED.

Agrochemicals -> Herbicides|Health Hazards -> Teratogens