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5-Methoxy-2-methylindole

5-Methoxy-2-methylindole structure

CAS No:
1076-74-0
Formula:
C10H11NO
Chemical Name:
5-Methoxy-2-methylindole
Synonyms:
1H-Indole,5-methoxy-2-methyl-;Indole,5-methoxy-2-methyl-;5-Methoxy-2-methyl-1H-indole;2-Methyl-5-methoxyindole;5-Methoxy-2-methylindole;NSC 63817
Categories:
Organic Chemistry > Heterocyclic Ring

Description

white to light beige crystalline powder or5-methoxy-2-methylindole is a useful organic raw material. It can be used as the reactant in the preparation of indolylquinoxalines by condensation reactions, in preparation of alkylindoles via Ir-catalyzed reductive alkylation, in arylation reactions in the presence of a palladium acetate catalyst, in enantioselective Friedel-Crafts alkylation, as well as in stereo selective synthesis of cyclopentaindolones via stereoselective [3+2] cyclopentannulation

5-Methoxy-2-methylindole Basic Attributes

Molecular Weight：

161.204

Exact Mass：

161.20

EC Number：

214-066-5

NSC Number：

63817

DSSTox ID：

DTXSID20148115

HScode：

29339900

Characteristics

PSA：

XLogP3：

Appearance：

white to light beige crystalline powder

Density：

1.0840 (rough estimate)

Melting Point：

89-90 °C

Boiling Point：

140-145 °C @ Press: 0.9-1.5 Torr

Flash Point：

113.1±12.6 °C

Refractive Index：

1.5200 (estimate)

Water Solubility：

soluble in methanol (very faint turbidity.)

Storage Conditions：

0-6ºC

Vapor Pressure：

0.00123mmHg at 25°C

Safety Information

Hazard category：

IRRITANT

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

R36/37/38

safety instructions：

37/39-26

Marks：

Precautionary statement(s)：

P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements：

H315

GHS Classification：

|Warning|H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]|P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501|Aggregated GHS information provided by 2 companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

5-Methoxy-2-methylindole Use and Manufacturing

An indole derivative shown to be an effective inhibitor of the chlorinating activity of myeloperoxidase (MPO). Used in the metabolic synthesis of arylacetic acid antiinflammatory synthesis. reactant in preparation of indolylquinoxalines by condensation reactions1reactant in preparation of alkylindoles via Ir-catalyzed reductive alkylation2reactant in arylation reactions using a palladium acetate catalyst3reactant in enantioselective Friedel-Crafts alkylation4reactant in stereoselective synthesi

Computed Properties

Molecular Weight:161.20
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:161.084063974
Monoisotopic Mass:161.084063974
Topological Polar Surface Area:25
Heavy Atom Count:12
Complexity:160
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

Recommended Suppliers of 5-Methoxy-2-methylindole

HANGZHOU LEAP CHEM CO., LTD. Contact Supplier

CN
5 YRS

Business licensed

Trader Supplier of Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals,Biochemicals,Pharmaceuticals,Screening Compounds,Food Additives

5-Methoxy-2-methyl-1H-indole

CAS No.: 1076-74-0

Content: 99.00%

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Hangzhou Royalchem Co.,LTD Contact Supplier

CN
2 YRS

Business licensed

Trader Supplier of Pharmaceutical intermediates

5-Methoxy-2-methylindole RC04332

Unit Price: $1 /KG EXW

CAS No.: 1076-74-0

Grade: Industrial Grade

Content: 99%

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