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Home > Encyclopedia > Methadone hydrochloride

Methadone hydrochloride

Methadone hydrochloride structure

Methadone hydrochloride 

structure
  • CAS No:

    1095-90-5

  • Formula:

    C21H27NO.ClH

  • Chemical Name:

    Methadone hydrochloride

  • Synonyms:

    3-Heptanone,6-(dimethylamino)-4,4-diphenyl-,hydrochloride (1:1);3-Heptanone,6-(dimethylamino)-4,4-diphenyl-,hydrochloride;6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride;Methadone hydrochloride;4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochloride;Mecodin;Adolan;Algidon;Algolysin;Butalgin;Depridol;dl-6-Dimethylamino-4,4-diphenyl-3-heptanone hydrochloride;4,4-Diphenyl-6-dimethylamino-3-heptanone hydrochloride (±)-;Dolophin hydrochloride;Fenadon;Fenadone;Hoechst 10820;Ketalgin hydrochloride;dl-Methadone hydrochloride;Miadone;Moheptan;Phenadone hydrochloride;Racemic methadone hydrochloride;(±)-Methadone hydrochloride;Adanon hydrochloride;Diaminon hydrochloride;Polamidon;Dolofin hydrochloride;AN 148;Mephenon;DL-Methadone hydrochloride;Dolophine;Heptadon;Adanon;Methadose;Ketalgin;Amidon;NSC 19600;D,L-Methadone hydrochloride;(±)-Methodone hydrochloride;125-56-4;70172-45-1;70181-39-4

Description

Methadone hydrochloride is a hydrochloride. It contains a methadone.|Methadose is a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|Methadone Hydrochloride is the hydrochloride salt of methadone, a synthetic opioid with analgesic activity. Similar to morphine and other morphine-like agents, methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily the mu-receptor, resulting in characteristic morphine-like effects including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. Because of the prolonged half-life of methadone compared to other morphine-like agents such as heroin, the onset of opiate withdrawal symptoms is slower, the duration of opiate withdrawal is prolonged, and opiate withdrawal symptoms are less severe.|A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)

Methadone hydrochloride Basic Attributes

66.487

65.987244

214-140-7

9250

19600

1851

DTXSID2020501

C638

2922399090

Characteristics

17.07000

1.25300

235 °C

477.8ºC at 760 mmHg

11 °C

Very soluble in ethanol

Methadone hydrochloride preparations should be stored in tight, light-resistant containers. Methadone hydrochloride oral concentrate and oral solution should be stored at 15-30 deg C; the tablets and injection should be stored at a controlled room temperature of 25 deg C, but may be exposed to temperatures ranging from 15-30 deg C.

Safety Information

UN 2811

R25

S45-S36/37

MJ6300000

T: Toxic;

Stable. Incompatible with strong oxidizing agents.

Missing Phrase - N15.00950417

H300

|Danger|H300 (94.59%): Fatal if swallowed [Danger Acute toxicity, oral]|P201, P202, P261, P264, P270, P271, P272, P280, P281, P285, P301+P310, P302+P352, P304+P340, P304+P341, P308+P313, P311, P312, P321, P322, P330, P333+P313, P342+P311, P361, P363, P403+P233, P405, and P501|Aggregated GHS information provided by 111 companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|H301 (97.44%): Toxic if swallowed [Danger Acute toxicity, oral]|P264, P270, P301+P310, P321, P330, P405, and P501|Aggregated GHS information provided by 39 companies from 2 notifications to the ECHA C&L Inventory.

Drug Information

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally. (See all compounds classified as Antitussive Agents.)|Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)|Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

Amidone

Methadone|Dolophine, Methadose, Amidone|9250|Schedule II - Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence.|Yes

Methadone hydrochloride Use and Manufacturing

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

Computed Properties

Molecular Weight:345.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:345.1859422
Monoisotopic Mass:345.1859422
Topological Polar Surface Area:20.3
Heavy Atom Count:24
Complexity:346
Undefined Atom Stereocenter Count:1
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

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