Molybdenum oxide (MoO3)

143.95800

145.89000

215-204-7

22FQ3F03YS

215191

3288

DTXSID7020899

WHITE OR SLIGHTLY YELLOW TO SLIGHTLY BLUISH POWDER OR GRANULES|COLORLESS OR WHITE YELLOW RHOMBIC CRYSTALS|WHITE POWDER AT ROOM TEMP, YELLOW AT ELEVATED TEMP

2825700000

51.21000

-0.35640

Molybdenum trioxide appears as colorless to white or yellow odorless solid. Sinks in water. (USCG, 1999)

4.69 g/cm³ @ Temp: 26 °C

795 °C

1155 °C

1155ºC subl.

H2O: 0.5 g/L (20 ºC)

None

READILY COMBINES WITH ACIDS & BASES TO FORM A SERIES OF POLYMERIC CMPD|PENTAVALENT MOLYBDENUM COMPLEXES ARE UNSTABLE TO OXIDATION, BUT HEXAVALENT MOLYBDENUM COMPLEXES WITH OXYGEN AS THE PREFERRED LIGAND & FORMS STABLE ISOPOLY & HETEROPOLY ACIDS & SALTS ... THESE POLYACIDS CAN REACT WITH PHOSPHATES & TARTRATES IN BIOLOGIC FLUIDS & TISSUES. BECAUSE OF PREFERRED AFFINITY OF MOLYBDENUM 6+ FOR OXYGEN LIGANDS, MOLYBDENUM BINDS TO CARBOXY GROUPS, HYDROXYL GROUPS, & ALSO SULFHYDRYL GROUPS PRESENT IN MACROMOLECULES. /MOLYBDENUM/

Insoluble in water.

Non-Redox-Active Inorganic Compounds

MOLYBDENUM TRIOXIDE reacts violently with chlorine trifluoride, lithium, potassium and sodium. Readily combines with acids and bases to form a series of polymeric compounds. Incompatible with interhalogens and metals. A violent detonation occurs when heated with molten magnesium. (NTP, 1992)

NONH for all modes of transport

1

R36/37; R48/20/22

S22-S25

QA4725000

Xn

P261-P281-P305 + P351 + P338

H319-H335-H351

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

/Incompatible with/ alkali metals; sodium, potassium, molten magnesium. /Molybdenum, sol compounds, (as Mo)/

USEPA, Office of Drinking Water; Criteria Document (Draft): Molybdenum (1985)|Nat'l Research Council Canada; Data Sheets on Selected Toxic Elements (1982) NRCC No. 19252|Toxicology & Carcinogenesis Studies of Molybdenum Trioxide in F344/N Rats and B6C3F1 Mice (Inhalation Studies). Technical Report Series No. 462 (1997) NIH Publication No. 97-3378 U.S. Department of Health and Human Services, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

Flash point data for this chemical are not available, but it is probably non-flammable. (NTP, 1992)

|Warning|H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]|P201, P202, P261, P264, P271, P280, P281, P304+P340, P305+P351+P338, P308+P313, P312, P337+P313, P403+P233, P405, and P501|H319 (99.93%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]|Aggregated GHS information provided by 1390 companies from 29 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.|Danger|H301: Toxic if swallowed [Danger Acute toxicity, oral]|P201, P202, P260, P264, P270, P281, P301+P310, P307+P311, P308+P313, P314, P321, P330, P405, and P501|P201, P202, P260, P261, P264, P270, P271, P280, P281, P304+P340, P305+P351+P338, P308+P313, P312, P314, P337+P313, P403+P233, P405, and P501

Fires associated with this material can be controlled with a dry chemical, carbon dioxide, or Halon extinguisher. (NTP, 1992)

Excerpt from ERG Guide 151 [Substances - Toxic (Non-combustible)]: As an immediate precautionary measure, isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids. SPILL: Increase, in the downwind direction, as necessary, the isolation distance shown above. FIRE: If tank, rail car or tank truck is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2016)

SMALL SPILLS AND LEAKAGE: If you spill this chemical, dampen the solid spill material with 5% ammonium hydroxide, then transfer the dampened material to a suitable container. Use absorbent paper dampened with 5% ammonium hydroxide to pick up any remaining material. Your contaminated clothing and the absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with 5% ammonium hydroxide followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned. STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures and away from all mineral acids and bases. (NTP, 1992)

U.S. Bu. Mines approved respirator; safety glasses or face shield; protective gloves (USCG, 1999)|US BUREAU OF MINES APPROVED RESPIRATOR; SAFETY GLASSES OR FACE SHIELD; PROTECTIVE GLOVES|Respirator selection: Upper limit devices recommended by OSHA: Up to 50 mg/cu m: any dust respirator except single-use and quarter-mask respirators or any supplied air respirator or any self-contained breathing apparatus; up to 125 mg/cu m: any powered air-purifying respirator with a dust and mist filter or any supplied-air respirator operated in a continuous flow mode; up to 250 mg/cu m: any air-purifying full facepiece respirator with a high-efficiency particulate filter or any powered air-purifying respirator with a tight-fitting facepiece and a high-efficiency particulate filter or any supplied-air respirator with a tight-fitting facepiece operated in a continuous flow mode or any self-contained breathing apparatus with a full facepiece or any supplied-air respirator with a full facepiece; up to 5000 mg/cu m: any supplied-air respirator with a half-mask and operated in a pressure-demand or other positive pressure mode; up to 7500 mg/cu m: any supplied-air respirator with a full facepiece and operated in a pressure-demand or other positive pressure mode; Emergency or planned entry in unknown concentration or IDLH conditions: any self-contained breathing apparatus with a full facepiece and operated in a pressure-demand or other positive pressure mode or any supplied-air respirator with a full facepiece and operated in a pressure-demand or other positive pressure mode in combination with an auxiliary self-contained breathing apparatus operated in pressure-demand or other positive pressure mode; Escape: any air-purifying full facepiece respirator with a high-efficiency particulate filter or any appropriate escape-type self-contained breathing apparatus. /Molybdenum, soluble compounds, (as Mo)/|Wear appropriate equipment to prevent repeated or prolonged skin contact. Wear eye protection to prevent reasonable probability of eye contact. /Molybdenum, soluble compounds (as Mo)/|Employees should be provided with and required to use impervious clothing, gloves, face shields (eight inch minimum), and other appropriate protective clothing necessary to prevent repeated or prolonged skin contact with soluble molybdenum compounds or liquids containing soluble molybdenum compounds. ... Employees should be provided with and required to use dust and splash proof safety goggles where soluble molybdenum compounds or liquids containing soluble molybdenum compounds may contact the eyes. /Soluble molybdenum compounds (as molybdenum)/|Respirators may be used when engineering and work practice controls are not technically feasible, when such controls are in the process of being installed, or when they fail and need to be supplemented. Respirators may also be used for operations which require entry into tanks or closed vessels, and in emergency situations. If the use of respirators is necessary, the only respirators permitted are those that have been approved by the Mine Safety and Health Administration (formerly Mining Enforcement and Safety Administration) or by the National Institute for Occupational Safety and Health. /Soluble Molybdenum cmpd (as Molybdenum); Molybdenum and insoluble molybdenum cmpd/

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.|Employees should wash promptly when skin becomes contaminated. Promptly remove nonimpervious clothing that becomes contaminated. /Molybdenum, soluble compounds (as Mo)/|... A complete respiratory protection program should be instituted which incl regular training, maintenance, inspection, cleaning, and evaluation. /Sol Molybdenum compounds (as Mo); Molybdenum and insoluble molybdenum compounds/

EXPOSURE TO MOLYBDENUM TRIOXIDE PRODUCES IRRITATION OF EYES AND THE MUCOUS MEMBRANES OF THE NOSE AND THROAT.

Permissible Exposure Limit: Table Z-1 8-hr Time Weighted Avg: 5 mg/cu m. /Molybdenum soluble compounds, as Mo/

Molybdenum in normal soil seems to vary between 0.1 and 10 mg/kg. In mining areas and near Molybdenum-emitting industries, considerably higher values have been reported. /Molybdenum/

In ambient air in urban areas, molybdenum ranged from 0.01 to 0.03 ug/cu m and in non urban areas it varied between 0.001 and 0.0032 ug/cu m. /Molybdenum/

METABOLISM OF MOLYBDENUM IN ANIMAL IS CLOSELY LINKED WITH THAT OF COPPER, WITH WHICH IT APPEARS TO HAVE RECIPROCAL ANTAGONISM ... /MOLYBDENUM/|THERE IS COMPLEX RELATIONSHIP BETWEEN MOLYBDENUM, COPPER & SULFATE, & PROBABLY SOME OTHER SULFUR CMPD. COPPER GENERALLY HAS BENEFICIAL EFFECT ON THE SYMPTOMS CAUSED BY EXCESSIVE MOLYBDENUM BUT THE ACTION OF THE SULFUR COMPOUNDS, ESPECIALLY SULFATE, IS NOT YET SO CLEARLY UNDERSTOOD. /MOLYBDENUM/|ANTAGONISM BETWEEN MOLYBDENUM & COPPER IS ... INFLUENCED IN A COMPLEX WAY BY DIETARY SULFATE, DEPENDING ON SPECIES: ... (1) SULFATE INTAKE CAUSES A REDISTRIBUTION OF MOLYBDENUM IN BLOOD CHARACTERIZED BY RED CELL DEPLETION; (2) SULFATE INCR ELIMINATION OF MOLYBDENUM FROM THE BODY; (3) DEPLETION OF HEPATIC COPPER WITH ASSOCIATED SIGNS OF COPPER DEFICIENCY FROM MOLYBDENUM OCCURS ONLY AT DIETARY LEVELS ABOVE SOME CRITICAL VALUE AND IS THUS AN ANTAGONISTIC EFFECT OF SULFATE ON MOLYBDENUM METABOLISM AND TOXICITY IN THE RAT ... /MOLYBDENUM/

LD50 Rat oral 125 mg/kg|LD50 Rat oral 83 mg Mo/kg as molybdenum trioxide. /Molybdenum trioxide/

Male and female F344/N rats and B6C3F1 mice were exposed to molybdenum trioxide (approximately 99% pure by inalation for ... 2 yr. ... 2 YEAR STUDIES IN RATS: Groups ot 50 male and 50 female F344/N rats were exposed to molybdenum tnoxide by inhalation at concn of 0, 10, 30 or 100 mg/cu m. Rats were exposed for 6 hr/day 5 days/wk, for 106 wk. ... 2 YEAR STUDY IN MICE: groups of 50 male and 50 female B6C3F1 mice were exposed to molybdenum trioxide by inhalation at concn of 0, 10, 30, or 100 mg/cu m. Mice were exposed for 6 hr/day, 5 days/wk for 105 wk/. ... CONCLUSIONS: Under the conditions of these 2 yr inhalation studies, there was equivocal evidence of carcinogenic activity of molybdenum trioxide in male F344/N rats based on a marginally significant positive trend of alveolar/bronchiolar adenoma or carcinoma (combined). There was no evidence of carcinogenic activity of molybdenum trioxide in female F344/N rats exposed to 10, 30, or 100 mg/cu m. There was some evidence of carcinogenic activity of molybdenum trioxide in male B6C3F1 mice based on increased incidences of alveolar/bronchiolar carcinoma and adenoma or carcinoma (combined). There was some evidence of carcinogenic activity of molybdenum trioxide in female B6C3F1 mice based on increased incidences of alveolar/bronchiolar adenoma and adenoma or carcinoma (combined).

In persons with impaired pulmonary function, especially those with obstructive airway diseases, the breathing of soluble molybdenum compounds might cause exacerbation of symptoms due to their irritant properties. ... Persons with preexisting blood disorders may be more susceptible to the effects of these agents. /Soluble molybdenum compounds (as Molybdenum)/|Molybdenum ingestion is associated with depleted copper stores in the body. Thus, humans who have an inadequate intake of dietary copper, or some dysfunction in their copper metabolism that tends to make them copper deficient, could be at greater risk of molybdenum toxicity than the general population. The importance of the kidney in regulating molybdenum excretion suggests that humans with renal dysfunction might also be at increased risk. /Molybdenum/

Soluble molybdate ions are present in trace concn in many surface waters .. as product of natural weathering of molybdenum bearing soils. /Molybdenum/|Both suspended insoluble molybdenum sulfide and soluble molybdates are present in streams that drain areas where molybdenum ore is mined and processed, especially in Colorado and New Mexico.

... THE FATE OF MOLYBDENUM IN A COAL FIRED ELECTRIC POWER PLANT IN COLORADO /WAS STUDIED/ ... RESULTS SHOWED THAT MOLYBDENUM FROM COAL IS ... ENRICHED IN FLY ASH LEAVING COAL FIRED POWER PLANT IN STACK GASES, (EVEN AFTER TREATMENT WITH ELECTROSTATIC PRECIPITATORS AND WET SCRUBBERS), BUT ... DECREASED IN BOTTOM ASH. ENRICHMENT IN FLY ASH APPEARS TO BE RELATED TO THE VOLATILITY OF MOLYBDENUM & ITS ADSORPTION ON FINE PARTICLES. MOLYBDENUM THAT ESCAPES IN PARTICULATE MATTER IN STACK GASES MAY BE EXPECTED TO SETTLE TO EARTH AND ENRICH SOIL, PLANTS, & WATER ... /MOLYBDENUM/|Soluble molybdate ions are present in trace concn in many surface waters, primarily as result of industrial waste ... /Molybdenum/|Molybdenum in sewage sludge was found to vary between 2 and 30 mg/kg dry weight. /Molybdenum/

SEAWATER: The concn of molybdenum in the ocean ... about 0.01 mg/l. SURFACE WATER: Levels in American rivers range from 5 to 30 mg/l. DRINKING WATER: Molybdenum in drinking water has been found to be between 0.11 ug/l and 6.2 ug/l. In mineral water ... levels are between 2.3 ug/l and 3.3 ug/l. /Molybdenum/|SEAWATER: PRESENT @ 12-16 PPB IN SEA WATER. /MOLYBDENUM/|SURFACE WATER: ... molybdenum /was measured/ in 59 samples of surface water from 15 rivers in the United States and Canada. The max concn observed was 6.9 ug/l, in the Colorado River at Yuma, Arizona. ... Molybdenum /was found/ in 32.7% of ... surface water samples from the 15 major river basins of the coterminous US, with concn ranging from 2.0 to 1,500 ug/l. The overall mean was 60 ug/l, and 26 stations had means greater than 50 ug/l. Of the 4 stations recording the highest values, 3 were in Colorado and one was just across the border on a stream draining from Colorado. /Molybdenum/|DRINKING WATER: In a survey of 380 finished waters in the United States between 1 Oct 1962 and 30 Sept 1967 ... /it was/ reported that 29.9% had measurable concn of molybdenum, with a max of 1,024 ug/l, a min of 3 ug/l, and a mean of 85.9 ug/l. GROUNDWATER: ... concn of molybdenum ranged from nil to 270 ug/l in groundwater ... SEAWATER: 0.1 to 0.5 ug/l in seawater. /Molybdenum/|DRINKING WATER: ... several trace metals in raw, treated, and tap water for the Denver municipal system /were studied/. This system draws its supplies from three watersheds (one being Dillon Reservoir) and treats them in four filter plants, one of which is an old, slow sand filter. Distributed water was sampled at four carefully selected locations in residences. On 15 Sept 1966, water from Dillon Reservoir reached 530 ug/l of molybdenum, but it was blended with water from the South Platte River before filtration. /Molybdenum/

The molybdenum content of food varies greatly. In general, legumes, cereals grains, leafy vegetables, liver, and kidney are good sources; fruits, root and stem vegetables, muscle meats, and dairy products are among the poorest. /Molybdenum/

Inhalation, ingestion or skin and/or eye contact. /Molybdenum, sol cmpd (as Mo)/|A SURVEY OF A MOLYBDATE ROASTING PLANT IN COLORADO, USA WAS MADE ... 25 MALE WORKERS WERE EXAMINED FOR BIOCHEMICAL ABNORMALITIES FROM EXPOSURE TO SOLUBLE MOLYBDENUM DUSTS. THE 8-HR TWA EXPOSURE TO SOLUBLE MOLYBDENUM (MAINLY MOLYBDENUM TRIOXIDE AND MOLYBDENUM OXIDES) WAS CALCULATED TO BE ABOUT 9.5 MG MOLYBDENUM/CU M, APPROXIMATELY DOUBLE THE RECOMMENDED TLV.|... Common operations in which exposure to molybdenum and insoluble molybdenum may occur ... /are/: liberation from mining and processing of ore; from grinding and other abrasive treatment of metal or alloys for use in electrical contacts, spark plugs, x-ray tubes, grids for radio tubes, missile and aircraft parts, and iron/steel alloys; use as lubricants in greases, oil dispersions, resin bonded films, and dry powders; as catalysts in petroleum refining and chemical processing; use in pigment mixture for labelling glass bottles, for printing inks, for paints, and for plastics; as reagents in analytical chemistry laboratories; use in powder as chemical intermediates; use in molybdic acid; use as alloying agents in prodn of iron/steel; use as catalysts in org synthesis in medicinals, in decorative coatings for metal, and as feed additives; liberation during temp application as protective coatings for electrical resistors and engine parts, and as catalysts; use as chemical intermediates and plating agents for mirrors; use in metal brazing and in manufacture of cutting tools; liberation during use as solid lubricants; liberation as catalysts in manufacture of propylene oxide; and use in chemical laboratory. /Molybdenum and insoluble molybdenum cmpd/|... Common operations in which exposure to soluble molybdenum compounds may occur ... /are/: liberation during rolling of hot billets in processing molybdenum steel; for use as electrodes; during welding operations; use as chemical reagent for lab analyses; in petroleum refining and chemical processing; as an intermediate in the manufacture of corrosion inhibitors; use as coloring agents for enamels and ceramic glazes; agricultural chemicals; use in electroplating process; use in formulation of corrosion inhibitors for aqueous systems; pigments for paints, lacquers, and coloring animal fibers and hair; use in enamel processes for adherence of vitreous coatings to ceramics and metal; use in leather and skin tanning; use as chlorination catalysts; in fire retardant resins; as a brazing flux and as an intermediate for organo metallic compunds; use in photography; ion exchange processes and formulation of plastics and adhesives; as a catalyst in desulfurization of gasoline, use as a reagent for determination of phosphorus and lead. /Soluble molybdenum compounds (as molybdenum)/

Humans: total body burden 9.3 mg amount in skeleton: 5 mg amount in liver: 2 mg kidney: 0.9-3.1 mg Mo/kg liver: 1.3-5.8 Mg mo/kg muscle: 0.018 mg Mo/kg bone: 0.7 mg Mo/kg hair: 0.06-0.2 mg Mo/kg nail: 0.15-16 mg Mo/kg whole blood: 0.001 mg Mo/kg.

Following rapid absorption from the gastrointestinal tract /of/ guinea pigs, molybdenum trioxide was found to be deposited rather uniformly in the critical organs within 4 hr ... .|Rats stored relatively more molybdenum from ingested molybdenum trioxide than from Powellite (CaMoO4). ... Significant storage above normal of molybdenum in bone was noted in all cases.|RABBITS SHOWED ... RAPID ABSORPTION OF MOLYBDENUM /AS MOLYBDENUM TRIOXIDE/ FOLLOWING INGESTION, WITH RAPIDLY RISING BLOOD LEVELS. MOLYBDENUM IS RAPIDLY ELIMINATED BY KIDNEYS, RETURNING ... TO NORMAL VALUES IN 72 HR ... FECAL ELIMINATION, WHICH IS ABOUT 1/2 THAT OF URINARY, RETURNED TO NORMAL ... IN 72 HR.|IN BLOOD, LEVEL DEPENDS LARGELY ON CONTENT OF MOLYBDENUM AND INORGANIC SULFATE IN DIET. ... RABBITS GIVEN SINGLE DOSE OF TRIOXIDE HAVE SHOWN A RISE FROM 130 TO 200 UG PER 100 ML, EVEN AS HIGH AS 1,850-1,970 UG ... .|For more Absorption, Distribution and Excretion (Complete) data for MOLYBDENUM TRIOXIDE (21 total), please visit the HSDB record page.

Data ... concerning excretion and the rapid clearance from the liver, kidney, spleen, testis, and hard tissues in animal studies show that the biological half time, at least for the most part of the absorbed molybdenum, must be in the order of hours and extending to a max of about one day in lab animals and cows. ... After a single subcutaneous injection in rats, the concentration of molybdenum in blood decr rapidly. After 24 hr, only about 1% of the max concn remained. During the next 10 days, concn in blood diminished with a half time of about 7 days. After application of doses up to 3 ug/kg to rats the biological half time was 3 hr for subcutaneous, and 6 hr for intragastric application. After single subcutaneous application of 0.02 to 1 ug molybdenum/kg to rats the biological half time in the kidneys, liver, spleen, jejunoileum, and skin varied between 2.5 and 4.7 days. /Molybdenum/

The mechanism of molybdenum toxicity is not yet quite understood. It is assumed that the primary factor is the formation of a copper-tetrathiomolybdate complex in the reduction medium of the gastrointestinal tract which reduces the biological utility of copper. /Molybdenum/|Molybdenum is an essential metal as a cofactor for the enzymes xanthine oxidase and aldehyde oxidase. /Molybdenum/

Compound is relatively nontoxic. Dust irritates eyes. (USCG, 1999)

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. INGESTION: Some heavy metals are VERY TOXIC POISONS, especially if their salts are very soluble in water (e.g., lead, chromium, mercury, bismuth, osmium, and arsenic). IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. Also locate Ipecac syrup or a glass of salt water in case the medical advisor recommends inducing vomiting. Usually, this is NOT RECOMMENDED outside of a physician's care. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

EXPTL THERAPY: SUPPLEMENTARY DIETARY CU2+, THIOSULFATE, METHIONINE & CYSTEINE EFFECTIVE IN ALLEVIATING MOLYBDENUM TOXICITY IN ANIMALS. /MOLYBDENUM/

Pneumoconiosis with x-ray findings and subjective symptoms has been reported in 3 out of 19 workers exposed to metallic molybdenum and molybdenum trioxide. Exposure varied between 1 and 19 mg/cu m for 4-7 years.|A SURVEY OF A MOLYBDATE ROASTING PLANT IN COLORADO WAS MADE ... 25 MALE WORKERS WERE EXAMINED FOR BIOCHEMICAL ABNORMALITIES FROM EXPOSURE TO SOLUBLE MOLYBDENUM DUSTS. THE 8-HR TWA EXPOSURE TO SOLUBLE MOLYBDENUM (MAINLY MOLYBDENUM TRIOXIDE AND MOLYBDENUM OXIDES) WAS CALCULATED TO BE ABOUT 9.5 MG MOLYBDENUM/CU M, APPROXIMATELY DOUBLE THE RECOMMENDED TLV. THE MEAN AGE OF THE WORKERS WAS 28.3 YR (RANGE 19 TO 44 YR) AND THE MEAN DURATION OF EMPLOYMENT, 4.0 YR (RANGE 0.5 TO 20 YR). ... ONLY ADVERSE BIOCHEMICAL FINDINGS WERE LARGE ELEVATIONS IN SERUM CERULOPLASMIN (AVG 50.47 + or - 1.38 MG/100 ML VERSUS 30.50 + or - 1.33 MG/100 ML FOR CONTROLS) AND SMALLER INCREMENTS IN SERUM URIC ACID LEVELS (5.90 + or - 0.24 MG/100 VERSUS 5.01 + or - 0.25 MG/100 ML FOR CONTROLS).|ANEMIA IS CHARACTERISTIC FEATURE OF MOLYBDENUM TOXICITY, WITH LOW HEMOGLOBIN CONCN AND REDUCED RED CELL COUNTS. /MOLYBDENUM COMPOUNDS/|INCR BLOOD URIC ACID VALUES & GOUT LIKE SYMPTOMS HAVE BEEN REPORTED ... AMONG THE GENERAL POPULATION LIVING IN AREA WITH HIGH MOLYBDENUM & LOW COPPER CONTENT IN SOILS & VEGETABLES. /MOLYBDENUM/|For more Human Toxicity Excerpts (Complete) data for MOLYBDENUM TRIOXIDE (6 total), please visit the HSDB record page.

molybdenum trioxide

(MOLYBDIC OXIDES) 87% USED IN MANUFACTURE OF STEEL AND STEEL ALLOYS; 6% FOR THE MANUFACTURE OF CAST IRON AND IRON ALLOYS; 4% USED IN THE MANUFACTURE OF CATALYSTS; 2% FOR CATALYSTS; 1% FOR MISC APPLICATIONS

GRADES: TECHNICAL; PURE; REAGENT, ACS

All other basic inorganic chemical manufacturing|Molybdenum oxide (MoO3): ACTIVE|HYDROGEN SULFIDE GASES ARE CONTACTED WITH ABSORBENT CONTAINING MOLYBDENUM OXIDE & TITANIUM DIOXIDE IN TITANIUM/MOLYBDENUM RATIO (30-99):(1-70) @ 100-300 °C TO REMOVE THE HYDROGEN SULFIDE.|WASTE GASES CONTAINING NITROGEN OXIDES ARE TREATED WITH AMMONIA @ 200-500 °C IN THE PRESENCE OF CATALYST CONTAINING AS A COMPONENT MOLYBDENUM TRIOXIDE.

NIOSH S-193: Analyte: molybdenum; Matrix: air; Procedure: atomic absorption; Range: 1.96-9.75 mg/cu m; Precision: 0.45 mg/cu m (std deviation) or 0.089 (coefficient of variation). /Molybdenum, sol cmpd/|With atomic absorption spectrophotometry, detection limit of 20 ug/l is attainable by direct aspiration into the flame, necessitating concn for ordinary determinations /of molybdenum in lake waters/. ... Extraction systems for molybdenum /are/ recommended /using/ an oxine-methylisobutylketone system with extraction @ a pH of 2 to 2.4. When the graphite furnace is used to increase sample atomization the detectiom limit is lowered to 0.5 ug/l. /Molybdenum/|NIOSH 7300: Analyte: molybdenum; Matrix: air; Technique: inductively coupled argon plasma, atomic emission spectroscopy; Wavelength: 281.6 nm; Range: 2.5-1000 ug/sample; LOD (Estimated limit of detection): 1 ug per sample; Sensitivity: 0.18 ug/ml; Precision: (relative std deviation): 0.023 @ 2.5 ug/filter, 0.049 @ 1000 ug/filter; Interferences: spectral, minimized by wavelength selection, interelement correction factors and background correction /Elements, molybdenum/|EPA Method 200.7: An Inductively Coupled Plasma-Atomic Emission Spectrophotmetric method for the determination of dissolved, suspended, or total elements in drinking water, surface water, and domestic and industrial wastewaters, is described. Molybdate is analyzed at a wavelength of 202.030 nm and has an estimated detection limit of 8 ug/l. /Total molybdenum/|For more Analytic Laboratory Methods (Complete) data for MOLYBDENUM TRIOXIDE (8 total), please visit the HSDB record page.

NIOSH 8310: Analyte: molybdenum; Specimen: urine; Technique: inductively coupled argon plasma, atomic emission spectroscopy; Extraction media: polydithiocarbamate resin; Wavelength: 281.6 nm; Range: 0.25-200 ug/sample; Est LOD (limit of detection): 0.1 ug/sample; Precision (relative std deviation): 0.16; Interferences: spectral minimized by wavelength selection /Metals in urine, molybdenum/|NIOSH 8005: Analyte: molybdenum; Specimen: blood or tissue; Technique: inductively coupled argon plasma atomic emission spectroscopy; Wavelength: 281.6 nm; Range: 10-10,000 ug/100 g blood, 2-2,000 ug/g tissue; Est LOD (limit of detection): 1 ug/100 g blood, 0.2 ug/g tissue; Precision: 3.1% (relative std deviation); Interferences: Spectral, minimized by wavelength selection and interelement correction factors /Elements in blood or tissue, molybdenum/|The determination of molybdenum in skin collagen using destructive neutron activation analysis revealed a sensitivity of 0.003 mg/kg. /Molybdenum/