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Paromomycin sulfate

Paromomycin sulfate structure

CAS No:
1263-89-4
Formula:
C23H45N5O14.xH2O4S
Chemical Name:
Paromomycin sulfate
Synonyms:
D-Streptamine,O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-,sulfate (1:?);D-Streptamine,O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-,sulfate (salt);D-Streptamine,O-2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-,sulfate (salt);Humycin sulfate;Paromomycin sulfate;Aminosidine sulfate;Aminosidin sulfate;Humatin;Gabbroral;Sinosid;Paramicina;Farmiglucin;Farminosidin;Pargonyl;Paricina;Aminoxidin;FI 5853;1600 Antibiotic;Humagel;1405-13-6;11048-06-9;14963-45-2;42438-81-3;51981-74-9
Categories:
Active Pharmaceutical Ingredients > Antibiotics

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Description

Paromomycin sulfate is effective as prophylaxis for cryptosporidiosis in dairy calves.

Paromomycin sulfate Basic Attributes

Molecular Weight：

713.71

Exact Mass：

713.263672

EC Number：

215-031-7

DSSTox ID：

DTXSID5047829

Characteristics

PSA：

430

Appearance：

powder

Melting Point：

145 °C (decomp)

Boiling Point：

1059.2°C at 760 mmHg

Flash Point：

522.2ºC

Water Solubility：

H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.

Storage Conditions：

0-6°C

Toxicity：

Oral-rat LD50: 21620 mg/kg; Oral-Mouse LD50: 23500 mg/kg

Flammability characteristics：

Flammable; burning produces toxic nitrogen oxides and sulfur oxide fumes

Specific rotation：

D25 +50.5° (c = 1.5 in water pH 6)

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

hazard class code：

23/24/25-36/38-39/23/24/25-61-36/37/38

safety instructions：

26-36/37-45-38-36

RTECS Number：

WK2320000

Marks：

Storage features：

Warehouse ventilated, low temperature and dry

GHS Classification：

Not Classified

Toxicity

Toxicity class：

practically nontoxic

Paromomycin sulfate Use and Manufacturing

an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.

Computed Properties

Molecular Weight:713.7
Hydrogen Bond Donor Count:15
Hydrogen Bond Acceptor Count:23
Rotatable Bond Count:9
Exact Mass:713.26368084
Monoisotopic Mass:713.26368084
Topological Polar Surface Area:430
Heavy Atom Count:47
Complexity:952
Defined Atom Stereocenter Count:17
Undefined Atom Stereocenter Count:2
Covalently-Bonded Unit Count:2
Compound Is Canonicalized:Yes

Drug Function and Efficacy

It has an inhibitory effect on both Gram-positive and Gram-negative bacteria, especially Shigella and Staphylococcus aureus, but has no effect on Pseudomonas aeruginosa and anaerobic bacteria. It has a strong inhibitory effect on amoeba, and also has a good effect on Leishmania, Cryptosporidium, filariasis, etc.

This ingredient has been used in drugs with the following functions (note: it does not mean that the ingredient itself has the following health functions)

Related Drugs

Paromomycin Sulfate Tablets
Ingredients	Aminoglycoside antibiotics.
Indication	This product should not be used in combination with other nephrotoxic or ototoxic drugs.
Specifications	0.25g (250,000 units)

Paromomycin Sulfate Tablets
Ingredients	The main ingredient of this product is paromomycin sulfate, its chemical name: O-2-amino-2-deoxy-alpha;-D-glucopyranosyl-(1rarr;4)-O-[O-2,6-diamino-2,6-dideoxy-beta;-L-opyranosyl-(1rarr;3)-beta;-D-ribofuranosyl-(1rarr;5)]-2-deoxy-D-streptamine sulfate
Indication	This product should not be used in combination with other nephrotoxic or ototoxic drugs.
Specifications	0.1g (100,000 units)

Paromomycin sulfate
Manufacturer	Kaifeng Pharmaceutical (GROUP) Co., Ltd.

See More Related Drugs

Registered Holders

OLON S.P.A.

Italy
Active
Kaifeng Pharmaceutical (GROUP) Co., Ltd.

China
Active
OLON S.p.A.

Japan
Active

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